公开(公告)号：WO2023019166A1

公开(公告)日：2023-02-16

申请号：PCT/US2022/074758

申请日：2022-08-10

Applicant: CALICO LIFE SCIENCES LLC ,  ABBVIE INC.

Inventor： VEITS, Gesine Kerstin ,  FITZGERALD, Mark E. ,  HIRD, Alexander W. ,  HENDERSON, James A. ,  VORA, Harit U. ,  SWEIS, Ramzi F. ,  KORT, Michael E. ,  MATULENKO, Mark

IPC: C07D409/14 ,  A61P35/00 ,  A61K31/454

Abstract: Provided herein are compounds, compositions, and methods useful for degrading protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases favorably responsive to PTPN1 or PTPN2 inhibitor treatment, e.g., a cancer or a metabolic disease.

公开(公告)号：WO2022271727A1

公开(公告)日：2022-12-29

申请号：PCT/US2022/034379

申请日：2022-06-21

Applicant: CALICO LIFE SCIENCES LLC ,  ABBVIE INC.

Inventor： VEITS, Gesine Kerstin ,  FITZGERALD, Mark E. ,  HIRD, Alexander W. ,  SWEIS, Ramzi F. ,  KORT, Michael E.

IPC: C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  A61P1/16 ,  A61P3/00 ,  A61P3/10 ,  A61P35/00 ,  A61K31/454 ,  A61K31/496 ,  A61K31/4995 ,  A61K31/444

Abstract: Provided herein are compounds, compositions, and methods useful for degrading protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases favorably responsive to PTPN1 or PTPN2 inhibitor treatment, e.g., a cancer or a metabolic disease.

公开(公告)号：WO2021127586A1

公开(公告)日：2021-06-24

申请号：PCT/US2020/066243

申请日：2020-12-18

Applicant: CALICO LIFE SCIENCES LLC ,  ABBVIE INC. ,  VEITS, Gesine Kerstin ,  FITZGERALD, Mark E. ,  HIRD, Alexander W. ,  HENDERSON, James A. ,  VORA, Harit U. ,  SWEIS, Ramzi F. ,  KORT, Michael E. ,  NASVESCHUK, Christopher G. ,  DUPLESSIS, Martin

Inventor： VEITS, Gesine Kerstin ,  FITZGERALD, Mark E. ,  HIRD, Alexander W. ,  HENDERSON, James A. ,  VORA, Harit U. ,  SWEIS, Ramzi F. ,  NASVESCHUK, Christopher G. ,  DUPLESSIS, Martin

IPC: C07D417/12 ,  C07D417/14 ,  C07D471/10 ,  A61P3/00 ,  A61P35/00 ,  A61K47/00 ,  A61K31/4523 ,  A61K31/4525 ,  A61K31/454 ,  A61K31/4545 ,  A61K9/0019

Abstract: Provided herein are compounds, compositions, and methods useful for degrading protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases favorably responsive to PTPN1 or PTPN2 inhibitor treatment, e.g., a cancer 5 or a metabolic disease.