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    BIOSENSOR TATTOOS AND USES THEREFOR FOR BIOMARKER MONITORING
    1.
    发明申请
    BIOSENSOR TATTOOS AND USES THEREFOR FOR BIOMARKER MONITORING 审中-公开
    生物传感器样品和用于生物标记监测的用途

    公开(公告)号：WO2016172554A1

    公开(公告)日：2016-10-27

    申请号：PCT/US2016/028948

    申请日：2016-04-22

    申请人： CARNEGIE MELLON UNIVERSITY ,  UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

    发明人： OZDOGANLAR, O. Burak ,  BRUCHEZ, Marcel, P. ,  CAMPBELL, Phil, G. ,  JARVIK, Jonathan, W. ,  FALO, Louis ,  ERDOS, Geza

    IPC分类号： C12Q1/68 ,  C12M1/34 ,  G01N33/68 ,  A01K67/027

    CPC分类号： C12M1/34 ,  A61M37/0015 ,  A61M37/0084 ,  A61M2037/0061 ,  C12N2750/14143 ,  C12N2830/002 ,  C12Q1/68 ,  C12Q2563/185 ,  G01N33/68

    摘要： Provided herein are devices and methods used to produce tattoo biosensors that are based on spatially controlled intracutaneous gene delivery of optical reporters driven by specific transcription factor pathways for a given cytokine or other analyte. The biosensors can be specific to a given analyte, or more generically represent the convergence of several cytokines into commonly shared intracellular transcription factor pathways. These biosensors can be delivered as an array in order to monitor multiple cytokines. Biosensor redeployment can enable chronic monitoring from months to years. The tattooed biosensor array of the present invention includes endogenous reporter cells, naturally tuned to each patient's own biology and can be used to reliably measure the state of a patient in real-time.

    摘要翻译： 本文提供了用于产生纹身生物传感器的装置和方法，所述纹身生物传感器基于由给定细胞因子或其他分析物的特定转录因子途径驱动的光学记录器的空间受控的皮内基因递送。 生物传感器可以对于给定的分析物是特异性的，或者更一般地代表几种细胞因子到通常共享的细胞内转录因子途径的收敛。 这些生物传感器可以作为阵列递送以便监测多种细胞因子。 生物传感器重新部署可以实现从数月到数年的慢性监测。 本发明的纹身生物传感器阵列包括内生报道细胞，其自然地被调谐到每个患者本身的生物学上，并可用于实时地可靠地测量患者的状态。

    ACTIVATABLE TWO-COMPONENT PHOTOSENSITIZERS
    3.
    发明申请
    ACTIVATABLE TWO-COMPONENT PHOTOSENSITIZERS 审中-公开
    可激活的双组分光敏剂

    公开(公告)号：WO2016081440A1

    公开(公告)日：2016-05-26

    申请号：PCT/US2015/061051

    申请日：2015-11-17

    申请人： CARNEGIE MELLON UNIVERSITY

    发明人： BRUCHEZ, Marcel, P. ,  HE, Jianjun ,  WANG, Yi

    IPC分类号： C07C233/36 ,  C07C233/40 ,  C07C211/43 ,  A61K41/00 ,  A61P35/00

    CPC分类号： A61K41/0057 ,  A61K47/64 ,  C07C211/43 ,  C07C233/36 ,  C07C233/40 ,  C09B11/10

    摘要： Provided herein is a two-component photosensitizer, which demonstrated robust and selective killing effects for transfected HEK cells and affibody targeted A431 cancer cells when exposed to near infrared light excitation. Free MG2I is a pure and stable fluorogen; it is easy to synthesize and modify, and has no toxicity to cells. Unlike conventional photosensitizers, the dye and FAP itself has no photosensitizing effect until they are bound. Also unlike other activation methods, the activation step is achieved by adding the fluorogen, not the presence of the targeted molecule, requiring an 'active' activation instead of a 'passive' activation. This method offers the ability to locally switch-on and selective generation of singlet oxygen at the target site and can be used for a wide variety of molecular targets.

    摘要翻译： 本文提供了一种双组分光敏剂，当暴露于近红外光激发时，其显示了对转染的HEK细胞和亲和体靶向的A431癌细胞的鲁棒和选择性杀伤作用。 免费的MG2I是一种纯而稳定的荧光; 易于合成和修饰，对细胞无毒性。 与传统的光敏剂不同，染料和FAP本身在结合之前就没有光敏作用。 与其他活化方法不同，活化步骤通过添加荧光素而不是靶向分子的存在来实现，需要“活性”活化而不是“被动”激活。 该方法提供了在目标位点局部开启和选择性生成单线态氧的能力，可用于各种分子靶标。