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    ACTIVATABLE TWO-COMPONENT PHOTOSENSITIZERS
    5.
    发明申请
    ACTIVATABLE TWO-COMPONENT PHOTOSENSITIZERS 审中-公开
    可激活的双组分光敏剂

    公开(公告)号：WO2016081440A1

    公开(公告)日：2016-05-26

    申请号：PCT/US2015/061051

    申请日：2015-11-17

    申请人： CARNEGIE MELLON UNIVERSITY

    发明人： BRUCHEZ, Marcel, P. ,  HE, Jianjun ,  WANG, Yi

    IPC分类号： C07C233/36 ,  C07C233/40 ,  C07C211/43 ,  A61K41/00 ,  A61P35/00

    CPC分类号： A61K41/0057 ,  A61K47/64 ,  C07C211/43 ,  C07C233/36 ,  C07C233/40 ,  C09B11/10

    摘要： Provided herein is a two-component photosensitizer, which demonstrated robust and selective killing effects for transfected HEK cells and affibody targeted A431 cancer cells when exposed to near infrared light excitation. Free MG2I is a pure and stable fluorogen; it is easy to synthesize and modify, and has no toxicity to cells. Unlike conventional photosensitizers, the dye and FAP itself has no photosensitizing effect until they are bound. Also unlike other activation methods, the activation step is achieved by adding the fluorogen, not the presence of the targeted molecule, requiring an 'active' activation instead of a 'passive' activation. This method offers the ability to locally switch-on and selective generation of singlet oxygen at the target site and can be used for a wide variety of molecular targets.

    摘要翻译： 本文提供了一种双组分光敏剂，当暴露于近红外光激发时，其显示了对转染的HEK细胞和亲和体靶向的A431癌细胞的鲁棒和选择性杀伤作用。 免费的MG2I是一种纯而稳定的荧光; 易于合成和修饰，对细胞无毒性。 与传统的光敏剂不同，染料和FAP本身在结合之前就没有光敏作用。 与其他活化方法不同，活化步骤通过添加荧光素而不是靶向分子的存在来实现，需要“活性”活化而不是“被动”激活。 该方法提供了在目标位点局部开启和选择性生成单线态氧的能力，可用于各种分子靶标。

    STERICALLY HINDERED PHOSPHINE LIGANDS AND USES THEREOF
    7.
    发明申请
    STERICALLY HINDERED PHOSPHINE LIGANDS AND USES THEREOF 审中-公开
    异种化学物质配体及其用途

    公开(公告)号：WO02048160A1

    公开(公告)日：2002-06-20

    申请号：PCT/US2001/047853

    申请日：2001-12-11

    IPC分类号： C07C45/68 ,  C07C209/10 ,  C07C211/48 ,  C07C211/54 ,  C07C253/30 ,  C07C255/41 ,  C07D295/023 ,  C07F9/50 ,  C07F15/00 ,  C07C211/43 ,  C07F15/02 ,  C07F15/04 ,  C07F15/06

    CPC分类号： C07D295/023 ,  C07C45/68 ,  C07C209/10 ,  C07C253/30 ,  C07F9/5004 ,  C07F9/5018 ,  C07F15/00 ,  C07C211/48 ,  C07C211/54 ,  C07C255/41

    摘要： The present invention is directed to a catalyst composition, comprising a Group 8 metal; and a ligand having a structure selected from the group consisting of: (a) wherein R, R' and R" are selected from the group consisting of H, a 1-10 carbon moiety, OR1, and NR2R3, wherein R1, R2, and R3 are each individually a 1-10 carbon moiety, with the proviso that one of R, R', or R" is not H, and that R, R', and R" together do not form an adamantyl moiety; and (b) wherein L is selected from the group consisting of a 1-30 carbon moiety with a tertiary carbon bound to phosphorous The present invention is also directed to a method of forming carbon-carbon, carbon-oxygen, carbon-sulfur, and carbon-nitrogen bonds between substrates using the above catalysts.

    摘要翻译： 本发明涉及一种催化剂组合物，其包含第8族金属; 和具有选自以下的结构的配体：（a）其中R，R'和R“选自H，1-10碳部分，OR 1和NR 2 R 3，其中R 1，R 2， 和R 3各自独立地为1-10碳部分，条件是R，R'或R“中的一个不为H，并且R，R'和R”一起不形成金刚烷基部分;和 b）其中L选自具有与磷结合的叔碳的1-30碳部分。本发明还涉及形成碳 - 碳，碳 - 氧，碳 - 硫和碳 - 碳的方法， 使用上述催化剂的底物之间的氮键。

    CATALYSTS FOR POLY(LACTIDE) SYNTHESIS AND USES THEREOF
    10.
    发明申请
    CATALYSTS FOR POLY(LACTIDE) SYNTHESIS AND USES THEREOF 审中-公开

    公开(公告)号：WO2014155213A3

    公开(公告)日：2014-10-02

    申请号：PCT/IB2014/059377

    申请日：2014-03-03

    申请人： INDIAN INSTITUTE OF TECHNOLOGY MADRAS

    发明人： CHAKRABORTY, Debashis ,  GHOSH, Swarup ,  VENKATACHALAM, Ramkumar

    IPC分类号： C07C211/43

    摘要： Catalysts for poly(lactide) synthesis are provided herein. Also provided are methods of synthesizing the catalysts, methods of using the catalysts to make poly(lactides), and compositions comprising the same. Synthetic petrochemical-based polymers have had an industrial impact since the 1940s. Despite the numerous advantages of these materials, two major drawbacks remain to be solved, namely, the use of nonrenewable resources for their production and the ultimate disposal of these large-scale commodity polymers.