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    METHODS AND COMPOSITIONS TO IDENTIFY, QUANTIFY, AND CHARACTERIZE TARGET ANALYTES AND BINDING MOIETIES
    1.
    发明申请
    METHODS AND COMPOSITIONS TO IDENTIFY, QUANTIFY, AND CHARACTERIZE TARGET ANALYTES AND BINDING MOIETIES 审中-公开
    确定，量化和表征目标分析和结合年龄的方法和组合物

    公开(公告)号：WO2017127556A1

    公开(公告)日：2017-07-27

    申请号：PCT/US2017/014151

    申请日：2017-01-19

    Applicant: CDI LABORATORIES, INC.

    Inventor： ZHU, Heng ,  QIAN, Jiang ,  PINO, Ignacio

    IPC: C12Q1/68 ,  G01N33/50 ,  C40B30/04

    CPC classification number: C12Q1/68 ,  C12Q1/6837 ,  C12Q1/6874 ,  G01N33/54306 ,  G01N2458/10 ,  C12Q2537/125 ,  C12Q2537/143 ,  C12Q2563/179 ,  C12Q2565/514

    Abstract: Proximity coupling and sequencing methods to screen identify, validate and/or characterize interactions between analytes and binding moieties are disclosed. Also disclosed herein are proximity coupling methods and sequencing methods to determine or quantify levels of target analytes. The disclosed methods can be multiplexed in two dimensions, and can be used to determine the affinity and specificity of each of a plurality of binding moieties for each of a plurality of target analytes. Also disclosed herein are substrates, arrays, and reagents for use in the methods, and methods of their preparation.

    Abstract translation: 公开了用于筛选鉴定，验证和/或表征分析物和结合部分之间的相互作用的接近偶联和测序方法。 本文还公开了确定或定量目标分析物水平的接近偶联方法和测序方法。 所公开的方法可以以二维方式多路复用，并且可以用于确定多个靶分析物中的每一个的多个结合部分中的每一个的亲和力和特异性。 本文还公开了用于所述方法及其制备方法的底物，阵列和试剂。

    METHODS AND COMPOSITIONS TO IDENTIFY, QUANTIFY, AND CHARACTERIZE TARGET ANALYTES AND BINDING MOIETIES
    5.
    发明申请
    METHODS AND COMPOSITIONS TO IDENTIFY, QUANTIFY, AND CHARACTERIZE TARGET ANALYTES AND BINDING MOIETIES 审中-公开
    识别，量化和表征目标分析和结合语言的方法和组合

    公开(公告)号：WO2016011364A1

    公开(公告)日：2016-01-21

    申请号：PCT/US2015/040924

    申请日：2015-07-17

    Applicant: CDI LABORATORIES, INC.

    Inventor： ZHU, Heng ,  QIAN, Jiang ,  PINO, Ignacio

    IPC: C12Q1/68 ,  C12M1/34

    CPC classification number: G01N33/5308 ,  C12N15/1048 ,  C12N15/1065 ,  C12Q1/6804 ,  C12Q1/6837 ,  G01N33/54306 ,  G01N33/54313 ,  C12Q2521/501 ,  C12Q2525/155 ,  C12Q2525/205 ,  C12Q2563/179

    Abstract: Proximity coupling and sequencing methods to screen, identify, validate and/or characterize interactions between analytes and binding moieties are disclosed. Also disclosed herein are proximity coupling methods and sequencing methods to determine or quantify levels of target analytes. The disclosed methods can be multiplexed in two dimensions, and can be used to determine the affinity and specificity of each of a plurality of binding moieties for each of a plurality of target analytes. Also disclosed herein are substrates, arrays, and reagents for use in the methods, and methods of their preparation.

    Abstract translation: 公开了用于筛选，鉴定，验证和/或表征分析物和结合部分之间的相互作用的近似偶联和测序方法。 本文还公开了用于确定或定量目标分析物水平的邻近耦合方法和测序方法。 所公开的方法可以在二维上复用，并且可以用于确定多个目标分析物中的每一个的多个结合部分中的每一个的亲和力和特异性。 本文还公开了用于该方法的底物，阵列和试剂及其制备方法。

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