公开(公告)号：WO2022173727A1

公开(公告)日：2022-08-18

申请号：PCT/US2022/015596

申请日：2022-02-08

申请人： CELGENE CORPORATION ,  ZOETIS LLC

发明人： HAWRYLUK, Natalie ,  KYNE, Graham ,  MENON, Sanjay ,  BEDORE, Matthew

IPC分类号： C07D403/12 ,  C07D401/12 ,  C07D403/14 ,  C07D405/12 ,  C07D215/40 ,  C07D401/04 ,  C07D471/04 ,  A61P33/10 ,  A61K31/4706 ,  A61K31/18

摘要： Provided herein are Sulfonamide compounds of Formula I: and pharmaceutically acceptable salts, tautomers, isotopologues, and stereoisomers thereof, wherein R1, R2, R, A, m, n, and p are as defined herein, compositions comprising an effective amount of a Sulfonamide Compound, and methods for treating or preventing animal and human filarial worm infections and diseases.

公开(公告)号：WO2022087326A1

公开(公告)日：2022-04-28

申请号：PCT/US2021/056127

申请日：2021-10-22

申请人： CELGENE CORPORATION ,  ZOETIS LLC

发明人： HAWRYLUK, Natalie ,  CANAN, Stacie ,  CONDROSKI, Kevin, R. ,  BEDORE, Matthew ,  KYNE, Graham ,  MENON, Sanjay

IPC分类号： C07D417/14 ,  C07D413/14 ,  C07D401/14 ,  C07D471/04 ,  C07D491/048 ,  A61P33/10 ,  A61K31/4402

摘要： Provided herein are Heterocyclic Compounds of formula (I), formula (II), formula (III), formula (IlIa), formula (Mb), formula (IIIc), formula (Hid), formula (IV), formula (IVa), formula (IVb), and formula (IVc), and pharmaceutically acceptable salts, tautomers, isotopologues, and stereoisomers thereof, compositions comprising an effective amount of a Heterocyclic Compound of formula (I), formula (II), formula (III), formula (IlIa), formula (Mb), formula (IIIc), formula (Hid), formula (IV), formula (IVa), formula (IVb), and formula (IVc), and methods for treating or preventing animal and human filarial worm infections and diseases.