公开(公告)号：WO2022087326A1

公开(公告)日：2022-04-28

申请号：PCT/US2021/056127

申请日：2021-10-22

申请人： CELGENE CORPORATION ,  ZOETIS LLC

发明人： HAWRYLUK, Natalie ,  CANAN, Stacie ,  CONDROSKI, Kevin, R. ,  BEDORE, Matthew ,  KYNE, Graham ,  MENON, Sanjay

IPC分类号： C07D417/14 ,  C07D413/14 ,  C07D401/14 ,  C07D471/04 ,  C07D491/048 ,  A61P33/10 ,  A61K31/4402

摘要： Provided herein are Heterocyclic Compounds of formula (I), formula (II), formula (III), formula (IlIa), formula (Mb), formula (IIIc), formula (Hid), formula (IV), formula (IVa), formula (IVb), and formula (IVc), and pharmaceutically acceptable salts, tautomers, isotopologues, and stereoisomers thereof, compositions comprising an effective amount of a Heterocyclic Compound of formula (I), formula (II), formula (III), formula (IlIa), formula (Mb), formula (IIIc), formula (Hid), formula (IV), formula (IVa), formula (IVb), and formula (IVc), and methods for treating or preventing animal and human filarial worm infections and diseases.

公开(公告)号：WO2022173727A1

公开(公告)日：2022-08-18

申请号：PCT/US2022/015596

申请日：2022-02-08

申请人： CELGENE CORPORATION ,  ZOETIS LLC

发明人： HAWRYLUK, Natalie ,  KYNE, Graham ,  MENON, Sanjay ,  BEDORE, Matthew

IPC分类号： C07D403/12 ,  C07D401/12 ,  C07D403/14 ,  C07D405/12 ,  C07D215/40 ,  C07D401/04 ,  C07D471/04 ,  A61P33/10 ,  A61K31/4706 ,  A61K31/18

摘要： Provided herein are Sulfonamide compounds of Formula I: and pharmaceutically acceptable salts, tautomers, isotopologues, and stereoisomers thereof, wherein R1, R2, R, A, m, n, and p are as defined herein, compositions comprising an effective amount of a Sulfonamide Compound, and methods for treating or preventing animal and human filarial worm infections and diseases.

公开(公告)号：WO2014039484A1

公开(公告)日：2014-03-13

申请号：PCT/US2013/057935

申请日：2013-09-04

申请人： ZOETIS LLC

发明人： MENON, Sanjay ,  SHEEHAN, Susan M.K. ,  VAILLIANCOURT, Valerie A.

IPC分类号： C07D491/10 ,  A61K31/397 ,  A61P33/00 ,  C07D491/20 ,  C07D495/10

CPC分类号： A01N43/90 ,  C07D491/20 ,  C07D495/10

摘要： The invention recites spirocyclic isoxazoline derivatives of Formula (1) stereoisomers thereof, veterinary or pharmaceutical acceptable salts thereof, compositions thereof, processes for making, and their use as a parasiticide in an animal. The variables W 1 , W 2 , W 3 , W, X, R 1a , R 1b , R 1c , R 2 , R 3 , R 4 , and n are as described herein.

摘要翻译： 本发明叙述其式（1）的立体异构体，其兽医或药学上可接受的盐，其组合物，制备方法及其作为动物中杀寄生物剂的用途的螺环异恶唑啉衍生物。 变量W1，W2，W3，W，X，R1a，R1b，R1c，R2，R3，R4和n如本文所述。