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1.发明申请SYNTHESIS OF CHIRAL AMPHETAMINE DERIVATIVES BY STEREOSPECIFIC, REGIOSELECTIVE CUPRATE ADDITION REACTION WITH AZIRIDINE PHOSPHORAMIDATE COMPOUNDS 审中-公开通过立体异构体合成氨基甲酸胺衍生物，与唑吡啶磷酸酯化合物进行反应性加成反应
公开(公告)号：WO2015130661A1
公开(公告)日：2015-09-03
申请号：PCT/US2015/017266
申请日：2015-02-24
Applicant: CHEMAPOTHECA, LLC
Inventor： MECKLER, Harold , GREGG, Brian Thomas , YANG, Jie
IPC: C07C211/01 , C07C209/62
CPC classification number: C07F9/564 , C07B2200/07 , C07C209/62 , C07F9/2458 , C07F9/2475 , C07C211/27
Abstract: The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions,
Abstract translation: 本发明包括合成苯丙胺，右旋苯丙胺，甲基苯丙胺，它们的衍生物，包括它们的盐的方法，以及由此获得的新型前体和中间体，通过在指定温度下合成特定溶剂中的氮丙啶氨基磷酸酯化合物，然后转化为新的芳基或 使用有机金属化合物例如铜盐的芳基 - 烷基氨基磷酸酯前体，其中新的芳基或芳基 - 烷基氨基磷酸酯前体然后可以使用已知的反应容易地转化成目标化合物，
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2.发明申请SYNTHESIS OF RACEMIC AMPHETAMINE DERIVATIVES BY CUPRATE ADDITION REACTION WITH AZIRIDINE PHOSPHORAMIDATE COMPOUNDS 审中-公开通过与AZIRIDINE磷酸酯化合物的添加反应合成聚合的氨基甲酸酯衍生物
公开(公告)号：WO2015130660A1
公开(公告)日：2015-09-03
申请号：PCT/US2015/017265
申请日：2015-02-24
Applicant: CHEMAPOTHECA, LLC
Inventor： MECKLER, Harold , GREGG, Brian Thomas , YANG, Jie
IPC: C07C211/01 , C07C209/62
CPC classification number: C07C209/62 , C07F9/2458 , C07F9/2475 , C07F9/564 , C07C211/27
Abstract: The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions.
Abstract translation: 本发明包括合成苯丙胺，右旋苯丙胺，甲基苯丙胺，它们的衍生物，包括它们的盐的方法，以及由此获得的新型前体和中间体，通过在指定温度下合成特定溶剂中的氮丙啶氨基磷酸酯化合物，然后转化为新的芳基或 使用有机金属化合物如铜盐的芳基 - 烷基氨基磷酸酯前体，其中新的芳基或芳基 - 烷基氨基磷酸酯前体然后使用已知的反应容易地转化成目标化合物。
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