公开(公告)号：WO2015130661A1

公开(公告)日：2015-09-03

申请号：PCT/US2015/017266

申请日：2015-02-24

Applicant: CHEMAPOTHECA, LLC

Inventor： MECKLER, Harold ,  GREGG, Brian Thomas ,  YANG, Jie

IPC: C07C211/01 ,  C07C209/62

CPC classification number: C07F9/564 ,  C07B2200/07 ,  C07C209/62 ,  C07F9/2458 ,  C07F9/2475 ,  C07C211/27

Abstract: The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions,

Abstract translation: 本发明包括合成苯丙胺，右旋苯丙胺，甲基苯丙胺，它们的衍生物，包括它们的盐的方法，以及由此获得的新型前体和中间体，通过在指定温度下合成特定溶剂中的氮丙啶氨基磷酸酯化合物，然后转化为新的芳基或 使用有机金属化合物例如铜盐的芳基 - 烷基氨基磷酸酯前体，其中新的芳基或芳基 - 烷基氨基磷酸酯前体然后可以使用已知的反应容易地转化成目标化合物，

公开(公告)号：WO2017147375A1

公开(公告)日：2017-08-31

申请号：PCT/US2017/019285

申请日：2017-02-24

Applicant: CHEMAPOTHECA, LLC

Inventor： POPP, Karl ,  MECKLER, Harold

IPC: A61P25/00 ,  A61K9/52

CPC classification number: A61K31/137 ,  A61K9/16 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2866

Abstract: The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.

Abstract translation: 本发明还涉及药物组合物，其包含由手性和外消旋苯丙胺衍生物通过与氮丙啶磷酰胺酯化合物立体特异性区域选择性铜酸盐加成反应合成的高纯度安非他明和苯丙胺类化合物，以及 通过立体有择的，区域选择性的铜酸盐与氮丙啶磷酰胺酯化合物的加成反应合成手性和外消旋苯丙胺衍生物制造，递送和使用苯异丙胺化合物。

公开(公告)号：WO2020180825A1

公开(公告)日：2020-09-10

申请号：PCT/US2020/020713

申请日：2020-03-02

Applicant: CHEMAPOTHECA, LLC

Inventor： MECKLER, Harold ,  CLEARY, Darryl ,  BRACKEEN, Marcus ,  SURYADEVARA, Praveen

IPC: C07C209/62 ,  C07C211/01 ,  C07F9/564

Abstract: This is invention is related to processes for synthesis of levoamphetamine derivatives and novel intermediates thereby, and processes for using the same.

公开(公告)号：WO2015130660A1

公开(公告)日：2015-09-03

申请号：PCT/US2015/017265

申请日：2015-02-24

Applicant: CHEMAPOTHECA, LLC

Inventor： MECKLER, Harold ,  GREGG, Brian Thomas ,  YANG, Jie

IPC: C07C211/01 ,  C07C209/62

CPC classification number: C07C209/62 ,  C07F9/2458 ,  C07F9/2475 ,  C07F9/564 ,  C07C211/27

Abstract: The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions.

Abstract translation: 本发明包括合成苯丙胺，右旋苯丙胺，甲基苯丙胺，它们的衍生物，包括它们的盐的方法，以及由此获得的新型前体和中间体，通过在指定温度下合成特定溶剂中的氮丙啶氨基磷酸酯化合物，然后转化为新的芳基或 使用有机金属化合物如铜盐的芳基 - 烷基氨基磷酸酯前体，其中新的芳基或芳基 - 烷基氨基磷酸酯前体然后使用已知的反应容易地转化成目标化合物。