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    SYSTEMS AND METHODS FOR DETECTING EDEMA
    1.
    发明申请
    SYSTEMS AND METHODS FOR DETECTING EDEMA 审中-公开
    用于检测EDEMA的系统和方法

    公开(公告)号：WO2018009670A1

    公开(公告)日：2018-01-11

    申请号：PCT/US2017/040910

    申请日：2017-07-06

    Applicant: CHEMIMAGE CORPORATION

    Inventor： STEWART, Shona ,  POST, J. Christopher ,  TREADO, Patrick ,  COHEN, Jeffrey

    IPC: A61B5/00 ,  A61B5/05 ,  A61B5/1455 ,  G01J3/28 ,  G01N21/17 ,  G02F1/1335

    Abstract: System and method for detecting and monitoring edema in a patient are described. Initially, a patient's tissue is irradiated with light by a light source. A detector collects reflected light from the patient's tissue and generates data associated with the reflected light. A processing device receives the data and reflected light and calculates an intensity of the reflected light. The processing device then determined, based upon the intensity of the reflected light, whether the patient's tissue exhibits any symptoms of edema. Additionally, the processing device can compare a current intensity of the reflected light against historic information to monitor for any changes in a patient's edema level or severity.

    Abstract translation: 描述了用于检测和监测患者水肿的系统和方法。 最初，患者的组织用光源照射光线。 检测器收集来自患者组织的反射光并生成与反射光相关的数据。 处理装置接收数据和反射光并计算反射光的强度。 处理装置然后基于反射光的强度来确定患者的组织是否表现出任何水肿症状。 另外，处理设备可以将反射光的当前强度与历史信息进行比较，以监测患者水肿水平或严重程度的任何变化。

    RAMAN-BASED IMMUNOASSAY SYSTEMS AND METHODS
    2.
    发明申请
    RAMAN-BASED IMMUNOASSAY SYSTEMS AND METHODS 审中-公开
    基于拉曼的免疫系统和方法

    公开(公告)号：WO2017087574A1

    公开(公告)日：2017-05-26

    申请号：PCT/US2016/062361

    申请日：2016-11-16

    Applicant: CHEMIMAGE CORPORATION

    Inventor： TREADO, Patrick ,  STEWART, Shona ,  SMITH, Aaron ,  GOMER, Heather

    IPC: G01J3/44 ,  A61B6/00 ,  G01N21/17 ,  G01N21/65 ,  G01N33/53

    CPC classification number: G01N21/65 ,  G01J3/44 ,  G01N2201/0833

    Abstract: This disclosure is directed to systems and methods for fusing Raman data with biomarker data to identify a disease and/or the progression of the disease. The system disclosed herein may include an illumination source for generating interacted photons from a biological sample and a detector for detecting the interacted photons to generate a Raman data set. A processor is included to fuse the Raman data set with a biomarker data set to identify a disease and/or a disease progression. The instant disclosure further includes a method comprising illuminating a biological sample to generate interacted photons, and detecting the interacted photons to generate a Raman data set. A biomarker data set is obtained from the biological sample, and the Raman data set is fused with the biomarker data set to generate an index score. The index score correlates with one or more of a disease and a disease progression.

    Abstract translation: 本公开涉及用于将拉曼数据与生物标志数据融合以鉴定疾病和/或疾病进展的系统和方法。 本文公开的系统可以包括用于生成来自生物样本的相互作用的光子的照射源和用于检测相互作用的光子以生成拉曼数据集的检测器。 包括处理器以将拉曼数据组与生物标志物数据组融合以识别疾病和/或疾病进展。 本公开还包括一种方法，该方法包括照射生物样本以生成相互作用的光子，并且检测相互作用的光子以生成拉曼数据集。 从生物样品获得生物标记数据集，并将拉曼数据集与生物标记数据集融合以产生指数分数。 指数评分与一种或多种疾病和疾病进展相关。

    SYSTEM AND METHOD FOR SERUM BASED CANCER DETECTION
    3.
    发明申请
    SYSTEM AND METHOD FOR SERUM BASED CANCER DETECTION 审中-公开
    基于血清的癌症检测系统及方法

    公开(公告)号：WO2014074569A1

    公开(公告)日：2014-05-15

    申请号：PCT/US2013/068671

    申请日：2013-11-06

    Applicant: CHEMIMAGE CORPORATION ,  TREADO, Patrick ,  STEWART, Shona ,  KIRSCHNER, Heather ,  PRIORE, Ryan ,  WILSON, Alan

    Inventor： TREADO, Patrick ,  STEWART, Shona ,  KIRSCHNER, Heather ,  PRIORE, Ryan ,  WILSON, Alan

    IPC: G01N33/574 ,  G01N33/48 ,  G01N33/53

    CPC classification number: G06F19/345 ,  G01J3/1804 ,  G01J3/44 ,  G01J3/4406 ,  G01N21/65 ,  G01N33/49 ,  G01N33/57419 ,  G06F19/24 ,  G16H50/20

    Abstract: A system and method for analyzing biological samples, such as dried human blood serum, to determine a disease state such as colorectal cancer (CRC). Using dried samples may hold potential for enhancing localized concentration and/or segmentation of sample components. The method may comprise illuminating at least one location of a biological sample to generate a plurality of interacted photons, collecting the interacted photons and generating at least one Raman data set representative of the biological sample. A system may comprise an illumination source to illuminate at least one location of a biological sample and generate at least one plurality of interacted photons, at least one mirror for directing the interacted photons to a detector. The detector may be configured to generate at least one Raman data set representative of the biological sample. The system and method may utilize a FAST device for multipoint analysis or may be configured to analyze a sample using a line scanning configuration.

    Abstract translation: 用于分析诸如干人血清的生物样品以确定诸如结肠直肠癌（CRC）的疾病状态的系统和方法。 使用干燥的样品可能具有增强样品组分的局部浓度和/或分割的潜力。 该方法可以包括照射生物样品的至少一个位置以产生多个相互作用的光子，收集相互作用的光子并产生代表生物样品的至少一个拉曼数据集。 系统可以包括照明源以照亮生物样品的至少一个位置并且生成至少一个多个相互作用的光子，至少一个反射镜，用于将相互作用的光子引导到检测器。 检测器可以被配置为产生代表生物样品的至少一个拉曼数据集。 系统和方法可以利用FAST设备进行多点分析，或者可以配置为使用线扫描配置来分析样本。

    MOLECULAR CHEMICAL IMAGING ENDOSCOPIC IMAGING SYSTEMS
    7.
    发明申请
    MOLECULAR CHEMICAL IMAGING ENDOSCOPIC IMAGING SYSTEMS 审中-公开

    公开(公告)号：WO2019212472A1

    公开(公告)日：2019-11-07

    申请号：PCT/US2018/030155

    申请日：2018-04-30

    Applicant: CHEMIMAGE CORPORATION

    Inventor： TREADO, Patrick ,  NELSON, Matthew

    IPC: A61B1/00 ,  A61B1/04 ,  A61B1/07

    Abstract: The instant disclosure provides for medical imaging systems that may be used in conjunction with an intraoperative medical device, such as an endoscope. Generally, the disclosed medical imaging systems include an illumination source configured to generate illuminating photons for illuminating a biological sample. An optical signal modulator is configured to separate one or more of the illuminating photons and photons that have interacted with the biological sample into a first optical signal having first multi-passband wavelengths and a second optical signal having second multi-passband wavelengths. At least one detector is configured to detect one or more of the first optical signal and the second optical signal and generate at least one image data set. A processor is configured to analyze the at least one image data set. In some embodiments, the processor is configured to differentiate between structures of the biological sample, such as between an ureter and surrounding tissue.

    METHOD FOR RAMAN COMPUTER TOMOGRAPHY IMAGING SPECTROSCOPY
    8.
    发明申请
    METHOD FOR RAMAN COMPUTER TOMOGRAPHY IMAGING SPECTROSCOPY 审中-公开
    拉曼计算机图像成像光谱法

    公开(公告)号：WO2006078980A2

    公开(公告)日：2006-07-27

    申请号：PCT/US2006/002176

    申请日：2006-01-19

    Applicant: CHEMIMAGE CORPORATION ,  MAIER, John, S. ,  TREADO, Patrick

    Inventor： MAIER, John, S. ,  TREADO, Patrick

    IPC: G01J3/44 ,  G01N21/65

    CPC classification number: G01J3/44 ,  G01J3/2823 ,  G01N21/65 ,  G01N2021/1787

    Abstract: A method for measuring spatial and spectral information from a sample using computed tomography imaging spectroscopy. An area of the sample is illuminated using an illumination source having substantially monochromatic light. Raman scattered light is directed from said illuminated area of said sample onto a two dimensional grating disperser. Light output, from the two dimensional grating disperser, is directed onto a detector that detects a dispersed image. The dispersed image from the detector is applied to a processing algorithm that generates a plurality of spatially accurate, wavelength resolved images of the sample.

    Abstract translation: 一种使用计算机断层摄影成像光谱从样本测量空间和光谱信息的方法。 使用具有基本上单色光的照明源照射样品的区域。 拉曼散射光从所述样品的所述照射区域引导到二维光栅分散器上。 来自二维光栅分散器的光输出被引导到检测器上，该检测器检测分散的图像。 来自检测器的分散图像被应用于产生样本的多个空间准确的波长分辨图像的处理算法。

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