公开(公告)号：WO2016128727A1

公开(公告)日：2016-08-18

申请号：PCT/GB2016/050294

申请日：2016-02-09

Applicant: CUBIC PHARMACEUTICALS LTD. ,  DELTA PHARMACEUTICALS LTD.

Inventor： DOUROUMIS, Dennis ,  MANIRUZZAMAN, Mohammed ,  BHATT, Saumil Kiritkumar ,  ALI, Anwar ,  JANGRA, Arun

IPC: A61K9/14 ,  A61K9/20 ,  A61K31/00 ,  B29B9/00

CPC classification number: A61K9/2095 ,  A61J3/10 ,  A61K9/143 ,  A61K9/20 ,  A61K31/00 ,  A61K31/192 ,  A61K33/12 ,  A61K47/32 ,  B29B9/00 ,  B29B9/06 ,  B29C47/0014 ,  B29C47/004

Abstract: The present invention relates to a method of producing a direct compression tablet composition comprising the step of processing ibuprofen, a hydrophilic polymer, and an inorganic excipient by an extrusion process to produce an extruded composition in which the ibuprofen forms a solid dispersion/solution within the hydrophilic polymer. The invention is particularly useful in preparing oral dissolvable tablets. Also provided are composition comprising an inorganic excipient and ibuprofen within a hydrophilic polymer.

Abstract translation: 本发明涉及直接压制片剂组合物的制造方法，其包括通过挤出方法处理布洛芬，亲水性聚合物和无机赋形剂的步骤，以产生挤出组合物，其中布洛芬在其内形成固体分散体/溶液 亲水聚合物。 本发明在制备口服可溶性片剂中特别有用。 还提供了在亲水性聚合物内包含无机赋形剂和布洛芬的组合物。

公开(公告)号：WO2016128726A1

公开(公告)日：2016-08-18

申请号：PCT/GB2016/050293

申请日：2016-02-09

Applicant: CUBIC PHARMACEUTICALS LTD. ,  DELTA PHARMACEUTICALS LTD.

Inventor： DOUROUMIS, Dennis ,  MANIRUZZAMAN, Mohammed ,  BHATT, Saumil Kiritkumar ,  ALI, Anwar ,  JANGRA, Arun

IPC: A61K9/14 ,  A61K9/20 ,  A61K31/00 ,  B29B9/00

CPC classification number: A61K9/143 ,  A61K9/145 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2095 ,  A61K31/00 ,  A61K31/192 ,  B29B9/00 ,  B29B9/06

Abstract: A method of producing an extruded, powdered/granulated composition comprising an active pharmaceutical ingredient (API), by the steps of providing an API and a porous inorganic excipient, and processing them by an extrusion process to directly produce an extruded, powdered/granulated composition wherein the API is at least partially absorbed within the pores of the inorganic excipient. In preferred embodiments, the API is melted, or solubilised in a solubilizer.

Abstract translation: 一种通过以下步骤制备包含活性药物成分（API）的挤出的粉末/颗粒状组合物的方法，其中提供API和多孔无机赋形剂，并通过挤出方法处理它们，以直接生产挤出的粉末/颗粒组合物 其中所述API至少部分地被吸收在所述无机赋形剂的孔内。 在优选的实施方案中，将API熔化或溶解在增溶剂中。