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公开(公告)号：WO2016128726A1
公开(公告)日：2016-08-18
申请号：PCT/GB2016/050293
申请日：2016-02-09
Applicant: CUBIC PHARMACEUTICALS LTD. , DELTA PHARMACEUTICALS LTD.
Inventor： DOUROUMIS, Dennis , MANIRUZZAMAN, Mohammed , BHATT, Saumil Kiritkumar , ALI, Anwar , JANGRA, Arun
CPC classification number: A61K9/143 , A61K9/145 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2095 , A61K31/00 , A61K31/192 , B29B9/00 , B29B9/06
Abstract: A method of producing an extruded, powdered/granulated composition comprising an active pharmaceutical ingredient (API), by the steps of providing an API and a porous inorganic excipient, and processing them by an extrusion process to directly produce an extruded, powdered/granulated composition wherein the API is at least partially absorbed within the pores of the inorganic excipient. In preferred embodiments, the API is melted, or solubilised in a solubilizer.
Abstract translation: 一种通过以下步骤制备包含活性药物成分（API）的挤出的粉末/颗粒状组合物的方法，其中提供API和多孔无机赋形剂，并通过挤出方法处理它们，以直接生产挤出的粉末/颗粒组合物 其中所述API至少部分地被吸收在所述无机赋形剂的孔内。 在优选的实施方案中，将API熔化或溶解在增溶剂中。
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公开(公告)号：WO2016128727A1
公开(公告)日：2016-08-18
申请号：PCT/GB2016/050294
申请日：2016-02-09
Applicant: CUBIC PHARMACEUTICALS LTD. , DELTA PHARMACEUTICALS LTD.
Inventor： DOUROUMIS, Dennis , MANIRUZZAMAN, Mohammed , BHATT, Saumil Kiritkumar , ALI, Anwar , JANGRA, Arun
CPC classification number: A61K9/2095 , A61J3/10 , A61K9/143 , A61K9/20 , A61K31/00 , A61K31/192 , A61K33/12 , A61K47/32 , B29B9/00 , B29B9/06 , B29C47/0014 , B29C47/004
Abstract: The present invention relates to a method of producing a direct compression tablet composition comprising the step of processing ibuprofen, a hydrophilic polymer, and an inorganic excipient by an extrusion process to produce an extruded composition in which the ibuprofen forms a solid dispersion/solution within the hydrophilic polymer. The invention is particularly useful in preparing oral dissolvable tablets. Also provided are composition comprising an inorganic excipient and ibuprofen within a hydrophilic polymer.
Abstract translation: 本发明涉及直接压制片剂组合物的制造方法，其包括通过挤出方法处理布洛芬，亲水性聚合物和无机赋形剂的步骤，以产生挤出组合物，其中布洛芬在其内形成固体分散体/溶液 亲水聚合物。 本发明在制备口服可溶性片剂中特别有用。 还提供了在亲水性聚合物内包含无机赋形剂和布洛芬的组合物。
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公开(公告)号：WO2017125720A1
公开(公告)日：2017-07-27
申请号：PCT/GB2017/050098
申请日：2017-01-16
Applicant: CUBIC PHARMACEUTICALS LTD. , IKS PHARMA
Inventor： MANIRUZZAMAN, Mohammed , BHATT, Saumil Kiritkumar , ALI, Anwar , JANGRA, Arun
IPC: A61K9/16
CPC classification number: A61K9/1688 , A61K9/1694
Abstract: The invention relates to a process of preparing a salt of an active pharmaceutical ingredient, the process comprising providing a blend of an active pharmaceutical ingredient and a salt forming substance, mixing the blend, optionally in the presence of added water, to react the active pharmaceutical ingredient with the salt forming substance to provide the salt of the active pharmaceutical ingredient; wherein when the active pharmaceutical ingredient is acidic, the salt forming substance is a base and the pKa difference between the acidic active pharmaceutical ingredient and the base is greater than 1, typically greater than 2 or preferably greater than 3; or when the active pharmaceutical ingredient is basic, the salt forming substance is an acid and the pKa difference between the basic active pharmaceutical ingredient and the acid is greater than 1, typically greater than 2 or preferably greater than 3,
Abstract translation: 本发明涉及一种制备活性药物成分的盐的方法，所述方法包括提供活性药物成分和成盐物质的混合物，混合所述混合物，任选地在 使活性药物成分与成盐物质反应以提供活性药物成分的盐; 其中当所述活性药物成分为酸性时，所述成盐物质为碱，并且所述酸性活性药物成分与所述碱的pKa差值大于1，通常大于2或优选大于3; 或者当活性药物成分是碱性时，成盐物质是酸并且碱性活性药物成分与酸之间的pKa差值大于1，通常大于2或优选大于3，
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