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    NOVEL 4-METHOXY PYRROLE DERIVATIVES OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
    3.
    发明申请
    NOVEL 4-METHOXY PYRROLE DERIVATIVES OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
    新的4-甲氧基吡咯烷酮衍生物或其盐及其包含其的药物组合物

    公开(公告)号：WO2016175555A2

    公开(公告)日：2016-11-03

    申请号：PCT/KR2016/004411

    申请日：2016-04-27

    申请人： DAEWOONG PHARMACEUTICAL CO., LTD.

    发明人： LEE, Chun Ho ,  LEE, Seung Chul ,  LEE, Yeon Im ,  EOM, Deok Ki ,  HAN, Mi Ryeong ,  KOH, Eun Ji

    IPC分类号： C07D207/48 ,  A61K31/40 ,  A61K31/095 ,  C07D207/30 ,  C07D207/335 ,  C07D207/36

    CPC分类号： C07D207/48

    摘要： The present invention provides a 4-methoxy pyrrole derivative or a pharmaceutically cceptable salt thereof, a preparation method thereof, and a pharmaceutical composition containing the same. The 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof according to the present invention have not only excellent proton pump inhibitory activity, gastric damage-inhibiting activity and defensive factor-enhancing effects, but also excellent eradication activity against H. pylori. Therefore, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof can be effectively used for the prevention and treatment of gastrointestinal damage due to gastrointestinal tract ulcer, gastritis, reflux esophagitis or H. pylori . Moreover, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof, have inhibitory activities against GPCR and thus can be effectively used for the prevention and treatment of 5-HT receptor-mediated or muscarinic acetylcholine receptor-mediated diseases.

    摘要翻译： 本发明提供4-甲氧基吡咯衍生物或其药学上可接受的盐，其制备方法和含有该化合物的药物组合物。 根据本发明的4-甲氧基吡咯衍生物或其药学上可接受的盐不仅具有优异的质子泵抑制活性，胃损伤抑制活性和防御因子增强作用，而且具有优异的针对幽门螺杆菌的根除活性。 因此，4-甲氧基吡咯衍生物或其药学上可接受的盐可有效地用于预防和治疗胃肠道溃疡，胃炎，反流性食管炎或幽门螺杆菌引起的胃肠损伤。 此外，4-甲氧基吡咯衍生物或其药学上可接受的盐对GPCR具有抑制活性，因此可有效地用于预防和治疗5-HT受体介导的或毒蕈碱性乙酰胆碱受体介导的疾病。

    NOVEL 4-METHOXY PYRROLE DERIVATIVES OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
    4.
    发明申请
    NOVEL 4-METHOXY PYRROLE DERIVATIVES OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开

    公开(公告)号：WO2016175555A8

    公开(公告)日：2016-11-03

    申请号：PCT/KR2016/004411

    申请日：2016-04-27

    申请人： DAEWOONG PHARMACEUTICAL CO., LTD.

    发明人： LEE, Chun Ho ,  LEE, Seung Chul ,  LEE, Yeon Im ,  EOM, Deok Ki ,  HAN, Mi Ryeong ,  KOH, Eun Ji

    IPC分类号： C07D207/48 ,  A61K31/40 ,  A61K31/095 ,  C07D207/30 ,  C07D207/335 ,  C07D207/36

    摘要： The present invention provides a 4-methoxy pyrrole derivative or a pharmaceutically cceptable salt thereof, a preparation method thereof, and a pharmaceutical composition containing the same. The 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof according to the present invention have not only excellent proton pump inhibitory activity, gastric damage-inhibiting activity and defensive factor-enhancing effects, but also excellent eradication activity against H. pylori. Therefore, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof can be effectively used for the prevention and treatment of gastrointestinal damage due to gastrointestinal tract ulcer, gastritis, reflux esophagitis or H. pylori . Moreover, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof, have inhibitory activities against GPCR and thus can be effectively used for the prevention and treatment of 5-HT receptor-mediated or muscarinic acetylcholine receptor-mediated diseases.

    NOVEL 4-METHOXY PYRROLE DERIVATIVES OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
    6.
    发明申请
    NOVEL 4-METHOXY PYRROLE DERIVATIVES OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
    新的4-甲氧基吡咯衍生物或其盐及包含该化合物的药物组合物

    公开(公告)号：WO2016175555A3

    公开(公告)日：2016-11-03

    申请号：PCT/KR2016/004411

    申请日：2016-04-27

    申请人： DAEWOONG PHARMACEUTICAL CO., LTD.

    发明人： LEE, Chun Ho ,  LEE, Seung Chul ,  LEE, Yeon Im ,  EOM, Deok Ki ,  HAN, Mi Ryeong ,  KOH, Eun Ji

    IPC分类号： C07D207/48 ,  A61K31/40 ,  A61K31/095 ,  C07D207/30 ,  C07D207/335 ,  C07D207/36

    摘要： The present invention provides a 4-methoxy pyrrole derivative or a pharmaceutically cceptable salt thereof, a preparation method thereof, and a pharmaceutical composition containing the same. The 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof according to the present invention have not only excellent proton pump inhibitory activity, gastric damage-inhibiting activity and defensive factor-enhancing effects, but also excellent eradication activity against H. pylori. Therefore, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof can be effectively used for the prevention and treatment of gastrointestinal damage due to gastrointestinal tract ulcer, gastritis, reflux esophagitis or H. pylori . Moreover, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof, have inhibitory activities against GPCR and thus can be effectively used for the prevention and treatment of 5-HT receptor-mediated or muscarinic acetylcholine receptor-mediated diseases.

    摘要翻译： 本发明提供4-甲氧基吡咯衍生物或其药学上可接受的盐，其制备方法和含有其的药物组合物。 根据本发明的4-甲氧基吡咯衍生物或其药学上可接受的盐不仅具有优异的质子泵抑制活性，胃损伤抑制活性和防御因子增强作用，而且还具有优异的抗H的根除活性。 因此，4-甲氧基吡咯衍生物或其药学上可接受的盐可以有效地用于预防和治疗由胃肠道溃疡，胃炎，反流性食管炎或H引起的胃肠道损伤。 幽门螺杆菌的。 此外，4-甲氧基吡咯衍生物或其药学上可接受的盐对GPCR具有抑制活性，因此可有效地用于预防和治疗5-HT受体介导的或毒蕈碱性乙酰胆碱受体介导的疾病。