公开(公告)号：WO2013008086A2

公开(公告)日：2013-01-17

申请号：PCT/IB2012/001366

申请日：2012-07-11

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD. ,  GUNA, Mircea

Inventor： GUNA, Mircea

IPC: H01J49/26

CPC classification number: H01J49/4265 ,  H01J49/004 ,  H01J49/422 ,  H01J49/427

Abstract: A method for operating a mass spectrometer having an ion trap over a plurality of selected mass-to-charge ranges constituting an overall mass- to-charge range is disclosed. For each of the plurality of selected mass-to- charge ranges the method comprises filling the ion trap with fragmented ions of the selected mass-to-charge ranges, cooling the fragmented ions trapped in the ion trap for a first cooling period, applying an RF voltage and a resolving direct current voltage to the ion trap for eliminating any remaining fragmented ions outside the selected ion mass-to-charge range and retaining ions within the selected ion mass-to-charge range, cooling the retained ions in the ion trap for a second cooling period, and scanning the retained ions out of the ion trap and detecting the ions released therefrom.

Abstract translation: 公开了一种操作质谱仪的方法，该质谱仪在构成总体质荷比范围的多个选定质荷比范围上具有离子阱。 对于多个选择的质荷比范围中的每一个，所述方法包括用选定的质荷比范围的碎片离子填充离子阱，冷却截留在离子阱中的碎片离子第一冷却时段， RF电压和解析直流电压到离子阱以消除选定离子质量电荷范围之外的任何剩余碎裂离子并将离子保持在选定离子质量电荷范围内，冷却离子阱中的保留离子 进行第二冷却阶段，并将保留的离子扫描离开离子阱并检测从其释放的离子。

公开(公告)号：WO2023026192A1

公开(公告)日：2023-03-02

申请号：PCT/IB2022/057895

申请日：2022-08-23

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： COX, David M. ,  GUNA, Mircea ,  KANG, Yang ,  MANOLESCU, Mircea ,  SONOC, Andrei

IPC: H01J49/42

Abstract: An ion mass filter for use in a mass spectrometer is disclosed, which includes a plurality of rods arranged in a multipole configuration to provide a passageway through which ions can travel, said plurality of rods being configured for application of RF voltages thereto to generate an electromagnetic field within the passageway for providing radial confinement of the ions and further configured for application of a DC voltage thereto, and at least two pairs of auxiliary electrodes interspersed between the plurality of multipole rods, where one pair forms a first pole of the auxiliary electrodes and the other pair forms a second pole of the auxiliary electrodes. A controller can provide one or more control signals to the DC voltage source so as to switch the polarity of the DC voltage differential between the two poles according to a predefined criterion.

公开(公告)号：WO2019008488A1

公开(公告)日：2019-01-10

申请号：PCT/IB2018/054864

申请日：2018-06-29

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： GUNA, Mircea

IPC: H01J49/06 ,  H01J49/04

Abstract: Systems and methods described herein relate to a mass spectroscopy system having multipole ion guides that can receive ions from an ion source for transmission to downstream mass analyzers, while preventing unwanted ions from being transmitted into the high-vacuum chambers of mass spectrometer systems. At least one ion guide can have two or more auxiliary electrodes that extend along at least a portion of the ion guide. A power supply provides an RF voltage to the poles of the ion guide for radially confining the ions within the internal volume of the ion guide. The auxiliary electrodes are also provided with an auxiliary electrical signal that can selectively radially deflect from the internal volume at least a portion of low m/z ions so as to prevent transmission of undesired low m/z ions into the downstream mass analyzers.

公开(公告)号：WO2017055978A1

公开(公告)日：2017-04-06

申请号：PCT/IB2016/055704

申请日：2016-09-23

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： GUNA, Mircea

IPC: H01J49/42

CPC classification number: H01J49/4225

Abstract: A linear ion trap includes a quadrupole having four substantially parallel conductive rods that are substantially coextensive in the axial direction. The rods include two diagonally arranged pairs including one continuous, rod pair and one pair of rods that are segmented such that the two segments in a rod are capacitively coupled to facilitate an RF drop when an RF signal is applied to one longer segment and capacitively provided to the other shorter segment. An RF signal is provided to the continuous rods and tire longer segment of the segmented rods.

Abstract translation: 线性离子阱包括具有四个基本上平行的导电棒的四极杆，其在轴向上基本上共延伸。 杆包括两个对角布置的对，包括一个连续的杆对和一对杆，其被分段成使得杆中的两个段电容耦合以便当将RF信号施加到一个较长的段并且电容性地提供时 到另一个较短的段。 将RF信号提供给连续杆并且轮胎分段杆的较长部分。

公开(公告)号：WO2013132308A1

公开(公告)日：2013-09-12

申请号：PCT/IB2013/000343

申请日：2013-03-08

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： GUNA, Mircea

IPC: H01J49/42

CPC classification number: H01J49/4265

Abstract: A two-dimensional substantially quadrupole field is provided. The field comprises a quadrupole harmonic of amplitude A2 and an octopole harmonic of amplitude A4, wherein A4 is greater than 0.01% of A2, A4 is less than 5% of A2, and, for any other higher order harmonic with amplitude An present in the field, n being any integer greater than 2 except 4, A4 is greater than ten times An.

Abstract translation: 提供二维基本四极场。 该场包括振幅A2的四极谐波和振幅A4的八极谐波，其中A4大于A2的0.01％，A4小于A2的5％，并且对于具有振幅A的任何其它高阶谐波，存在于 场，n除了4以外大于2的任何整数，A4大于An的十倍。

公开(公告)号：WO2015097504A1

公开(公告)日：2015-07-02

申请号：PCT/IB2014/002550

申请日：2014-11-20

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： GUNA, Mircea

IPC: H01J49/26

CPC classification number: H01J49/4205 ,  H01J49/0031 ,  H01J49/009 ,  H01J49/061

Abstract: Methods and apparatus for operating a mass spectrometer are described. In various aspects, ions of a mass range of interest may be mass-selectively ejected from an accumulation ion trap into a multi-ion trap structure. Each ion trap of the multi-ion trap structure may be configured to confine ions within a portion of the mass range of interest. The ions may be simultaneously scanned from the ion traps of the multi-ion trap structure for concurrent detection at a detector component.

Abstract translation: 描述了用于操作质谱仪的方法和装置。 在各个方面，感兴趣质量范围的离子可以从积聚离子阱大量选择性地喷射到多离子阱结构中。 多离子阱结构的每个离子阱可以被配置为将离子限制在感兴趣质量范围的一部分内。 可以从多离子阱结构的离子阱同时扫描离子，以便在检测器组件处进行同时检测。

公开(公告)号：WO2013098599A1

公开(公告)日：2013-07-04

申请号：PCT/IB2012/002520

申请日：2012-11-28

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： GUNA, Mircea

IPC: H01J49/26 ,  H01J49/10 ,  H01J49/06

CPC classification number: H01J49/0045 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/10

Abstract: A method of operating a tandem mass spectrometer system is disclosed including accumulating ions in an ion trap, transmitting a plurality of ions out of the ion trap into a timed-ion selector, applying a pulsed DC voltage to the timed-ion selector, the pulsed DC voltage being modulated to match an ejection time for selecting a first portion of ions from the plurality of ions, corresponding to a specific m/z window, transmitting the first portion of selected ions out of the timed-ion selector into a reaction cell, transmitting dissociation product ions and the remaining ions of the first portion of selected ions out of the reaction cell into a mass analyzer, and mass-selectively transmitting at least some of the fragment ions and the remaining ions of the first portion of selected ions out of the mass analyzer into a detector.

Abstract translation: 公开了一种操作串联质谱仪系统的方法，包括在离子阱中积聚离子，将多个离子从离子阱中传输到定时离子选择器中，将脉冲DC电压施加到定时离子选择器，脉冲 直流电压被调制以匹配喷射时间，用于从对应于特定m / z窗口的多个离子中选择离子的第一部分，将选定离子的第一部分从定时离子选择器传输到反应池中， 将离解产物离子和选定离子的第一部分的剩余离子从反应池中转移到质量分析器中，并且批量选择性地将选定离子的第一部分中的至少一些碎片离子和剩余离子从 质量分析仪成为检测器。

公开(公告)号：WO2023026190A1

公开(公告)日：2023-03-02

申请号：PCT/IB2022/057893

申请日：2022-08-23

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： COX, David M. ,  FAUR, Manuel ,  GUNA, Mircea ,  KANG, Yang ,  SONOC, Andrei

IPC: H01J49/42

Abstract: In one aspect, an ion filter for use in a mass spectrometer is disclosed, which includes a plurality of rods arranged in a multipole configuration to provide a passageway through which ions can travel, said plurality of rods being configured for application of RF voltages thereto to provide an electromagnetic field within the passageway for providing radial confinement of the ions and further configured for application of a DC voltage thereto. At least two pairs of auxiliary electrodes are interspersed between the plurality of rods and are configured for application of a DC bias voltage with one polarity to one of said pairs and a DC bias voltage with an opposite polarity to the other one of said pairs to provide a DC potential difference between the auxiliary electrodes and the plurality of rods.

公开(公告)号：WO2022172155A1

公开(公告)日：2022-08-18

申请号：PCT/IB2022/051118

申请日：2022-02-08

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： GUNA, Mircea ,  SONOC, Andrei

IPC: H01J49/00

Abstract: In one aspect, a method of performing mass spectrometry is disclosed, which comprises introducing a plurality of ions into a mass spectrometer, selecting a portion of the precursor ions having m/z ratios within a first desired range to provide a plurality of precursor ions, causing fragmentation of at least a portion of the precursor ions to generate a plurality of product ions, selecting a portion of the product ions having m/z ratios within a second desired range, and performing mass analysis of the selected productions.

公开(公告)号：WO2020049487A1

公开(公告)日：2020-03-12

申请号：PCT/IB2019/057459

申请日：2019-09-04

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： GUNA, Mircea

IPC: H01J49/00 ,  H01J49/42

Abstract: In one aspect, a method of processing ions in a mass spectrometer is disclosed, which comprises trapping a plurality of ions having different mass-to-charge (m/z) ratios in a collision cell, releasing said ions from the collision cell in a descending order in m/z ratio, and receiving the ions in a mass analyzer having a plurality of rods to at least one of which an RF voltage is applied, where the RF voltage is varied from a first value to a lower second value as the released ions are received by the mass analyzer.