公开(公告)号：WO2016197123A2

公开(公告)日：2016-12-08

申请号：PCT/US2016/036050

申请日：2016-06-06

Applicant: DOUGLAS SCIENTIFIC, LLC

Inventor： HJELSETH, Robert ,  HODGSON, Cory ,  BRISTOW, Andrew ,  BAUMGARTNER, Mark ,  SELLNOW, David ,  KEPPEL, Cassie ,  STECKELBERG, John ,  NEWMAN, Paul

IPC: B01L3/00 ,  G01N1/28 ,  C12M3/00

CPC classification number: B01L3/50 ,  B01L3/502 ,  B01L3/508 ,  B01L3/5635 ,  B01L2200/026 ,  B01L2200/0631 ,  B01L2300/021 ,  B01L2300/044 ,  B01L2300/0681 ,  B01L2300/0832 ,  B01L2400/0457 ,  C12M45/06

Abstract: Embodiments of the invention provide a filter kit including filters for processing a biological sample. Some embodiments include a filter cap in a tube kit with a first tube containing a buffer solution and a second tube containing a lyophilized master mix. Some embodiments include a method of processing a sample using the kit including mixing a biological sample in a first tube with the buffer solution, positioning the filter cap in the first tube, positioning a second tube on the filter cap, flipping the first tube, the filter cap, and the second cap to filter the biological sample and buffer solution mixture with the filter cap as it flows from the first tube to the second tube. Some embodiments include structure enabling transfer of materials through inline flow between the tubes. Some further embodiments include integrated structure for sample pulverization with integrated buffer and lyophilized master mix.

Abstract translation: 本发明的实施方案提供了一种过滤器套件，其包括用于处理生物样品的过滤器。 一些实施例包括管套件中的过滤器盖，其中包含缓冲溶液的第一管和含有冻干的主混合物的第二管。 一些实施方案包括使用试剂盒处理样品的方法，包括将第一管中的生物样品与缓冲溶液混合，将过滤帽定位在第一管中，将第二管定位在过滤帽上，翻转第一管， 过滤器盖和第二帽，以便当过滤帽从第一管流向第二管时，过滤生物样品和缓冲溶液混合物与过滤嘴盖。 一些实施例包括能够通过管之间的直列流传输材料的结构。 一些另外的实施方案包括用于具有集成缓冲液和冻干的主混合物的样品粉碎的整体结构。

公开(公告)号：WO2016154555A1

公开(公告)日：2016-09-29

申请号：PCT/US2016/024260

申请日：2016-03-25

Applicant: DOUGLAS SCIENTIFIC, LLC

Inventor： MISCHE, Hans ,  PEXSA, Grant ,  BAUMGARTNER, Mark ,  HODGSON, Cory ,  BRISTOW, Andrew ,  STECKELBERG, John ,  PATTERSON, Jared

IPC: G01N33/48 ,  G01N21/63 ,  C12M1/34

CPC classification number: G01N21/6428 ,  B01L3/527 ,  B01L7/52 ,  B01L2300/0609 ,  B01L2300/0893 ,  G01N21/253 ,  G01N21/645 ,  G01N33/50 ,  G01N2021/6439 ,  G01N2021/6482 ,  G01N2201/024 ,  G01N2201/062 ,  G01N2201/0691

Abstract: A modular testing device includes a base unit and an expansion unit that communicates with the base unit. The expansion unit includes a housing, a receptacle in which a sample holder containing a biological sample and reagent mixture can be placed, and an optical assembly positioned in the housing. The optical assembly is configured to amplify and detect a signal from the biological sample and reagent mixture. Data that is collected in the optical assembly is communicated to the base unit.

Abstract translation: 模块化测试装置包括与基本单元通信的基本单元和扩展单元。 膨胀单元包括壳体，其中可以放置容纳生物样品和试剂混合物的样品保持器的容器和位于壳体中的光学组件。 光学组件被配置为放大并检测来自生物样品和试剂混合物的信号。 收集在光学组件中的数据被传送到基本单元。