公开(公告)号：WO2012135498A2

公开(公告)日：2012-10-04

申请号：PCT/US2012/031209

申请日：2012-03-29

申请人： DR. BAKER SAYS, INC. ,  BAKER, Andrew

发明人： BAKER, Andrew

IPC分类号： A23L1/30 ,  A61K31/20 ,  A61K31/201 ,  A61K36/00

CPC分类号： A61K45/06 ,  A23L33/115 ,  A23L33/12 ,  A61K31/201 ,  A61K36/22 ,  A61K36/48 ,  A61K36/52 ,  A61K36/54 ,  A61K36/55 ,  A61K2300/00

摘要： The present invention provides a novel composition of nut and seed oils, specifically; walnut oil, almond oil, avocado oil, pistachio oil and flaxseed oil for use in maintaining and improving health in a convenient and cost-effective manner; for obtaining essential fatty acids that are required for normal body functioning; for reducing cholesterol, and for reducing retinal degeneration in an individual with retinitis pigmentosa.

摘要翻译： 本发明提供了一种新颖的坚果和种子油组合物; 核桃油，杏仁油，鳄梨油，开心果油和亚麻籽油，用于维持和改善健康，方便和具有成本效益的方式; 用于获得正常身体功能所需的必需脂肪酸; 用于降低胆固醇，并减少患有色素性视网膜炎的个体的视网膜变性。

公开(公告)号：WO2012153135A1

公开(公告)日：2012-11-15

申请号：PCT/GB2012/051018

申请日：2012-05-09

申请人： UNIVERSITY OF GLASGOW ,  CAMBRIDGE ENTERPRISE LIMITED ,  BAKER, Andrew ,  MACLEAN, Margaret ,  MORRELL, Nicholas

发明人： BAKER, Andrew ,  MACLEAN, Margaret ,  MORRELL, Nicholas

IPC分类号： C12N15/113 ,  A61K31/713 ,  A61K31/712

CPC分类号： C12N15/113 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2310/3231

摘要： The present invention provides a method of treating or preventing pulmonary arterial hypertension in a subject in need thereof by administering to the subject an inhibitor of miR-145 expression or activity. Pharmaceutical compositions and kits comprising miR-145 inhibitors for treating pulmonary arterial hypertension are also disclosed.

摘要翻译： 本发明提供了通过向受试者施用miR-145表达或活性的抑制剂来治疗或预防有需要的受试者的肺动脉高压的方法。 还公开了包含用于治疗肺动脉高血压的miR-145抑制剂的药物组合物和试剂盒。

公开(公告)号：WO2007085863A1

公开(公告)日：2007-08-02

申请号：PCT/GB2007/000299

申请日：2007-01-30

申请人： CERES INTELLECTUAL PROPERTY COMPANY LIMITED ,  SELCUK, Ahmet ,  MAYNARD, Neill ,  HARRINGTON, Matthew ,  EL Koury, Karim ,  BAKER, Andrew ,  GIRVAN, Bruce

发明人： SELCUK, Ahmet ,  MAYNARD, Neill ,  HARRINGTON, Matthew ,  EL Koury, Karim ,  BAKER, Andrew ,  GIRVAN, Bruce

IPC分类号： H01M8/02

CPC分类号： H01M8/0247 ,  H01M8/0206 ,  H01M8/0208 ,  H01M8/021 ,  H01M8/0215 ,  H01M8/0228 ,  H01M8/0232 ,  H01M8/0245 ,  H01M8/0271 ,  H01M8/0273 ,  H01M8/028 ,  H01M8/241 ,  H01M8/242 ,  H01M8/2432 ,  H01M8/248 ,  H01M8/2483 ,  H01M8/249 ,  H01M2008/1293 ,  Y02P70/56 ,  Y10T29/49108

摘要： The present invention is concerned with a fuel cell comprising : an electrolyte layer defining first and second faces and with said first face mounted on and in electrochemical contact with a first electrode and with said second face mounted on and in electrochemical contact with a second electrode, and an electrically conductive current collector joined to or mounted on or in said second electrode and in electrical contact with said second electrode, said electrically conductive current collector having an at least one extension extending outwards of a perimeter defined by said first and second electrodes and said electrolyte, fuel cell stack assemblies comprising same and methods of manufacture of same.

摘要翻译： 本发明涉及一种燃料电池，包括：限定第一和第二面的电解质层，并且所述第一面安装在第一电极上并与第一电极电化学接触，并且所述第二面安装在第二电极上并与之电化学接触， 以及连接到或安装在所述第二电极上或所述第二电极中并与所述第二电极电接触的导电集电器，所述导电集电器具有至少一个从由所述第一和第二电极限定的周边向外延伸的延伸部分， 电解质，包括其的燃料电池堆组件及其制造方法。

公开(公告)号：WO2012010997A2

公开(公告)日：2012-01-26

申请号：PCT/IB2011/052844

申请日：2011-06-28

申请人： KIMBERLY-CLARK WORLDWIDE, INC. ,  RANGANATHAN, Sridhar ,  BAKER, Andrew ,  FEASTER, Shawn, R. ,  MADSEN, Edward, B. ,  SCHORR, Phillip

发明人： RANGANATHAN, Sridhar ,  BAKER, Andrew ,  FEASTER, Shawn, R. ,  MADSEN, Edward, B. ,  SCHORR, Phillip

CPC分类号： G01L7/022 ,  A61M16/04 ,  A61M16/0434 ,  A61M16/044 ,  A61M16/0484 ,  A61M16/0486 ,  A61M2205/3331 ,  A61M2205/583 ,  A61M2205/584 ,  G01L7/024

摘要： A pressure indicator for cuffed tracheal tubes is provided. This indicator uses an indicator balloon on the proximal end of the inflation lumen and in fluid communication with the tracheal tube cuff. As the pressure in the cuff changes, the balloon will inflate and deflate. An indicator needle rests on the balloon and moves in response to the inflation and deflation of the balloon, thus showing the state of inflation of the cuff.

摘要翻译： 提供了气管插管的压力指示器。 该指示器使用充气腔的近端上的指示气囊并与气管管箍流体连通。 随着袖带压力的变化，气球会膨胀和放气。 指示针位于气球上，响应于气囊的充气和放气而移动，从而显示袖带的膨胀状态。

公开(公告)号：WO2012016652A1

公开(公告)日：2012-02-09

申请号：PCT/EP2011/003712

申请日：2011-07-20

申请人： SERVICES PETROLIERS SCHLUMBERGER ,  SCHLUMBERGER TECHNOLOGY B.V. ,  SCHLUMBERGER HOLDINGS LIMITED ,  SCHLUMBERGER CANADA LIMITED ,  PRAD RESEARCH AND DEVELOPMENT LIMITED ,  BAKER, Andrew ,  AYAN, Cosan

发明人： BAKER, Andrew ,  AYAN, Cosan

IPC分类号： G01F1/36 ,  G01F1/44 ,  G01F1/704 ,  G01F1/74 ,  G01F5/00 ,  G01F25/00 ,  G01F1/34

CPC分类号： G01F1/74 ,  G01F1/44 ,  G01F1/704 ,  G01F25/0007

摘要： Both a flow meter system and method are provided for accurately measuring the percentage amounts of liquid and gas phases in a multiphase flow through a conduit when the liquid phase constitutes a small minority portion (e.g., less than about 20%) of the multiphase flow. The system includes a flow meter that includes a differential pressure sensor connected across a Venturi in the conduit, and a dual energy fraction meter, each of which is operably connected to a digital processor. The system further includes a pump connected to the conduit upstream of the flow meter that introduces at least one pulse of a known quantity of liquid, the pulse being sufficient in volume to temporarily increase the liquid phase by a detectable amount. After the liquid pulse is introduced into the multiphase flow, the digital processor computes the changes in the percentage amounts of the liquid and gas phases which should have occurred as a result of the pulse, and compares the computed changes with the actual changes measured by the flow meter in order to calibrate the flow meter. The measured increase in the liquid flow is then subtracted from the total measured liquid flow to determine the actual percentage of liquid flow.

摘要翻译： 提供了一种流量计系统和方法，用于当液相构成多相流的少量部分（例如，小于约20％）时，精确地测量通过导管的多相流中的液相和气相的百分比量。 该系统包括流量计，该流量计包括连接在管道中的文氏管两端的差压传感器，以及双能量分数表，每个能量分数表可操作地连接到数字处理器。 该系统还包括连接到流量计上游的导管的泵，其引入已知量的液体的至少一个脉冲，该脉冲的体积足以临时将液相增加可检测量。 在将液体脉冲引入多相流之后，数字处理器计算作为脉冲结果应该发生的液相和气相百分比的变化，并将计算出的变化与由 流量计为了校准流量计。 然后从总测量的液体流中减去所测量的液体流量的增加，以确定液体流量的实际百分比。

公开(公告)号：WO2011162879A1

公开(公告)日：2011-12-29

申请号：PCT/US2011/035874

申请日：2011-05-10

申请人： SOURCEFIRE, INC. ,  VOGEL III, William, Andrew ,  BAKER, Andrew

发明人： VOGEL III, William, Andrew ,  BAKER, Andrew

IPC分类号： G06F9/44 ,  H04L29/06

CPC分类号： H04L63/1433 ,  H04L41/12

摘要： A system includes a processor device. The processor device is configured to receive reports of operating system identities for a single host; determine which of the operating system identities are an intersection of the reported operating system identities; and assign the intersection of the reported operating system identities as a resolved operating system identity.

摘要翻译： 系统包括处理器设备。 处理器设备被配置为接收针对单个主机的操作系统身份的报告; 确定哪个操作系统身份是报告的操作系统身份的交集; 并将所报告的操作系统身份的交集分配为解决的操作系统身份。

公开(公告)号：WO2012000645A1

公开(公告)日：2012-01-05

申请号：PCT/EP2011/003165

申请日：2011-06-28

申请人： SERVICES PETROLIERS SCHLUMBERGER ,  SCHLUMBERGER TECHNLOLOGY B.V. ,  SCHLUMBERG HOLDINGS LIMITED ,  SCHLUMBERG CANADA LIMITED ,  PRAD RESEARCH AND DEVELOPMENT LIMITED ,  LUPEAU, Alexandre ,  BAKER, Andrew ,  CADALEN, Sébastien ,  FOURNIER, Benoît

发明人： LUPEAU, Alexandre ,  BAKER, Andrew ,  CADALEN, Sébastien ,  FOURNIER, Benoît

IPC分类号： G01F1/74

CPC分类号： G01F1/74 ,  G01F1/44 ,  G01F1/50

摘要： A flow meter apparatus and method are presented for measuring a flow rate of a multiphase fluid mixture comprising at least one gas phase and one liquid phase. The flow meter comprises a pipe section and measurement section through which the mixture flows. The flow meter also comprises a fraction measurement device adapted to estimate a representative fraction of the gas phase and/or liquid phase of the mixture passing at the measurement section. Moreover, the flow meter preferably comprises at least one ultrasonic sensor arranged to estimate a characteristic, such as liquid film thickness or velocity, of a portion of the liquid phase flowing as liquid film along a wall of the pipe section. The characteristic is preferably used to correct the estimated representative fraction of the gas phase and/or liquid phase when the gas phase flows in a core of the pipe section, and a portion of the liquid phase flows partially as liquid film along the wall of the pipe section and another portion of the liquid phase flows partially as liquid droplets in the core of the pipe section.

摘要翻译： 提供了一种用于测量包含至少一个气相和一个液相的多相流体混合物的流量的流量计装置和方法。 流量计包括管部分和混合物流过的测量部分。 流量计还包括适于估计通过测量部分的混合物的气相和/或液相的代表性分数的分数测量装置。 此外，流量计优选地包括至少一个超声波传感器，该超声波传感器布置成估计作为液膜沿着管部分的壁流动的液相的一部分液相的特性，例如液膜厚度或速度。 当气相在管段的芯中流动时，该特征优选用于校正气相和/或液相的估计代表分数，并且一部分液相部分地作为液膜沿着壁的壁 管段和另一部分液相部分地作为管段的芯中的液滴流动。

公开(公告)号：WO2012168807A2

公开(公告)日：2012-12-13

申请号：PCT/IB2012/052201

申请日：2012-05-02

申请人： KIMBERLY-CLARK WORLDWIDE, INC. ,  ROSS, Russell, Frederick ,  BAKER, Andrew

发明人： ROSS, Russell, Frederick ,  BAKER, Andrew

IPC分类号： A61M37/00 ,  A61M5/158 ,  A61M5/168

CPC分类号： A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0038

摘要： The present invention includes a microneedle assembly having a support that includes a first surface and a second surface, the second surface further including a slanted surface. A plurality of microneedles are provided which project outwardly from the second surface of the support. A pathway through the microneedle assembly is formed and includes an aperture extending between the first surface of the support and the second surface of the support, a channel disposed on the exterior surface of at least one microneedle, the channel having a surface, the channel being in alignment with at least a portion of the aperture to form a junction through which fluids may pass.

摘要翻译： 本发明包括具有包括第一表面和第二表面的支撑件的微针组件，所述第二表面还包括倾斜表面。 设置有从支撑体的第二表面向外突出的多个微针。 形成通过微针组件的路径，并且包括在支撑件的第一表面和支撑件的第二表面之间延伸的孔，设置在至少一个微针的外表面上的通道，通道具有表面，通道为 与孔的至少一部分对准以形成流体可以通过的连接点。

公开(公告)号：WO2012000655A1

公开(公告)日：2012-01-05

申请号：PCT/EP2011/003188

申请日：2011-06-27

申请人： SERVICES PETROLIERS SCHLUMBERGER ,  SCHLUMBERGER TECHNOLOGY B.V ,  SCHLUMBERGER HOLDINGS LIMITED ,  SCHLUMBERGER CANADA LIMITED ,  PRAD RESEARCH AND DEVELOMENT LIMITED ,  LUPEAU, Alexandre ,  BAKER, Andrew

发明人： LUPEAU, Alexandre ,  BAKER, Andrew

IPC分类号： G01F1/36 ,  G01F1/74

CPC分类号： G01F1/36 ,  G01F1/74 ,  G01N33/2823

摘要： An apparatus (1 ) for measuring at least one characteristic value of a multiphase fluid mixture (13) comprises: a pipe section (20) having a main flow path through which the multiphase fluid mixture (13) flows, the main flow path comprising a throat (22) between an upstream part (21) and a downstream part (23) of the main flow path such as to generate a pressure drop between the upstream part (21 ) and the downstream part (23); a first sensing arrangement (28, 33, 29, 34, 35, 36) to measure a first characteristic value of the multiphase fluid mixture (13) flowing into the main flow path; -a channel (25) being positioned within the wall of the pipe section (20) such as to maintain similar operating conditions as in the main flow path, the channel (25) being coupled to the main flow path by an inlet (24) at the upstream part (21 ), or the throat (22), and by an outlet (26) at the downstream part (23), or the throat (22), such that the pressure drop generates an aspiration effect diverting a sample of the multiphase fluid mixture (13) flowing through the main flow path into the channel (25), the channel (25) having an internal diameter (70) such that said multiphase fluid mixture sample flows in successive separated enriched phase samples (42, 52) within the channel (25); and a second sensing arrangement (30) to measure a second characteristic value of one of the phase of the multiphase fluid mixture sample flowing into the channel (25).

摘要翻译： 一种用于测量多相流体混合物（13）的至少一个特征值的装置（1），包括：具有多个流体混合物（13）流过的主流路的管段（20），所述主流路包括 在主流路的上游部分（21）和下游部分（23）之间的喉部（22），以在上游部分（21）和下游部分（23）之间产生压降; 第一感测装置（28,33,29,34,35,36），用于测量流入主流路的多相流体混合物（13）的第一特征值; - 通道（25）定位在管部分（20）的壁内，以便维持与主流路相似的操作条件，通道（25）通过入口（24）联接到主流路， 在上游部分（21）或喉部（22）处，以及通过下游部分（23）或喉部（22）处的出口（26），使得压降产生将样品 所述多相流体混合物（13）通过所述主流动路径流入所述通道（25），所述通道（25）具有内径（70），使得所述多相流体混合物样品在连续分离的富含相样品（42,52）中流动 ）在通道（25）内; 以及第二感测装置（30），用于测量流入通道（25）的多相流体混合物样品的相的一个的第二特征值。

公开(公告)号：WO2009098492A2

公开(公告)日：2009-08-13

申请号：PCT/GB2009/000363

申请日：2009-02-09

申请人： BAKER, Andrew ,  WADDINGTON, Simon ,  MCVEY, John

发明人： BAKER, Andrew ,  WADDINGTON, Simon ,  MCVEY, John

IPC分类号： A61K38/16 ,  A61K35/58 ,  C07K16/06 ,  A61K48/00 ,  G01N33/569 ,  G01N33/68 ,  A61K38/48 ,  C12N15/861

CPC分类号： A61K38/162 ,  A61K35/58 ,  A61K38/4846 ,  A61K48/00 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10345 ,  C12N2810/6018 ,  C12N2810/857 ,  G01N33/56983 ,  G01N2333/075 ,  G01N2333/745 ,  G01N2500/02

摘要： The invention provides materials and methods for modulating adenoviral tropism for hepatocytes and other cell types such as splenocytes. It relates to the findings that hypervariable regions (HVRs) of the viral hexon protein interact with the Gla domain of the blood clotting factor FX as part of the infective process in vivo. The invention provides means to disrupt the interaction between hexon and FX, thus reducing infection of hepatocytes and splenocytes, as well as use of targeting agents comprising the Gla domain or a fragment thereof to direct adenoviral vectors to desired target cell or tissue types.

摘要翻译： 本发明提供用于调节肝细胞和其他细胞类型如脾细胞的腺病毒向性的材料和方法。 它涉及病毒六邻体蛋白的高变区（HVR）与凝血因子FX的Gla结构域作为体内感染过程的一部分相互作用的发现。 本发明提供了破坏六邻体和FX之间的相互作用的手段，从而减少肝细胞和脾细胞的感染，以及使用包含Gla结构域或其片段的靶向剂以将腺病毒载体引导至期望的靶细胞或组织类型。