GLYCOSIDE HYDOLASES AND THEIR USE IN PREVENTING AND/OR TREATING A PATHOGENIC INFECTION IN AN ANIMAL
    4.
    发明申请
    GLYCOSIDE HYDOLASES AND THEIR USE IN PREVENTING AND/OR TREATING A PATHOGENIC INFECTION IN AN ANIMAL 审中-公开
    甘氨酸胶囊及其在预防和/或治疗动物恶病质感染中的应用

    公开(公告)号:WO2017040499A1

    公开(公告)日:2017-03-09

    申请号:PCT/US2016/049439

    申请日:2016-08-30

    CPC classification number: A61K38/47

    Abstract: Disclosed are methods and compositions using glycoside hydrolases, such as an alpha-L-fucosidases, to prevent and/or treat a pathogenic infection and/or diarrhea in an animal wherein the pathogenic infection is caused by a pathogen capable of binding to an animal intestinal cell wherein said binding of the pathogen is dependent on the presence of a pathogen binding site having at least one glycan structure substituted with at least one alpha-1,2-L-fucose moiety comprising administering to the animal an effective amount of a glycoside hydrolase capable of removing the at least one alpha-1,2-L-fucose moiety from the pathogen binding site.

    Abstract translation: 公开了使用糖苷水解酶(例如α-L-岩藻糖苷酶)来预防和/或治疗动物中的病原性感染和/或腹泻的方法和组合,其中致病性感染由能够结合动物肠道的病原体引起 细胞,其中所述病原体的结合取决于具有被至少一个α-1,2-L-岩藻糖部分取代的至少一个聚糖结构的病原体结合位点的存在,包括向动物施用有效量的糖苷水解酶 能够从病原体结合位点除去至少一个α-1,2-L-岩藻糖部分。

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