公开(公告)号：WO1998017805A2

公开(公告)日：1998-04-30

申请号：PCT/US1997019424

申请日：1997-10-24

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, c/o Centers for Disease Control and Prevention, Technology Transfer Office ,  EMORY UNIVERSITY ,  RIBOT, Efrain, M. ,  STEPHENS, David, S. ,  RAYMOND, Nigel ,  QUINN, Frederick, D.

Inventor： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, c/o Centers for Disease Control and Prevention, Technology Transfer Office ,  EMORY UNIVERSITY

IPC: C12N15/31

CPC classification number: C07K14/22 ,  A61K38/00

Abstract: Genes isolated from Neisseria meningitidis, as well as isolated nucleic acids, probes, expression cassettes, polypeptides, antibodies, immunogenic compositions, antisense nucleic acids, amplification mixtures and new invasion deficient strains of Neisseria meningitidis are provided. Methods of detecting Neisseria meningitidis and Neisseria meningitidis nucleic acids, and methods of inhibiting the invasion of mammalian cells by Neisseria menigitidis are also provided.

Abstract translation: 提供从脑膜炎奈瑟氏球菌分离的基因，以及分离的核酸，探针，表达盒，多肽，抗体，免疫原性组合物，反义核酸，扩增混合物和新的脑膜炎奈瑟氏球菌侵袭缺陷菌株。 还提供了检测脑膜炎奈瑟菌和脑膜炎奈瑟氏球菌核酸的方法，以及抑制奈瑟氏球菌引起的哺乳动物细胞侵袭的方法。

公开(公告)号：WO1997041729A1

公开(公告)日：1997-11-13

申请号：PCT/US1997007821

申请日：1997-05-06

Applicant: EMORY UNIVERSITY ,  BIO-SHIELD TECHNOLOGIES, INC.

Inventor： EMORY UNIVERSITY ,  BIO-SHIELD TECHNOLOGIES, INC. ,  LIEBESKIND, Lanny, S. ,  ALLRED, Gary, D. ,  MOSES, Timothy, C. ,  ELFERSY, Jacques

IPC: A01N55/10

CPC classification number: D06P1/64 ,  A01N55/00 ,  A23L3/00 ,  A23L3/3463 ,  A23L3/349 ,  A23L3/3526 ,  A23L3/3544 ,  A23L5/42 ,  A61L2/18 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/216 ,  A61L2300/404 ,  A61L2300/606 ,  C07F7/1804 ,  C12H1/00 ,  D06M13/513 ,  D06M15/643 ,  D06M16/00 ,  D06M23/005 ,  D06P1/5292 ,  D06P1/62 ,  Y10S514/97 ,  Y10S514/971 ,  C08L83/04

Abstract: A method of dyeing and treating a substrate using a water-stabilized organosilane. A method of antimicrobially treating a food article. A method of antimicrobially coating a fluid container. A method of antimicrobially coating a latex medical article.

Abstract translation: 使用水稳定性有机硅烷染色和处理基材的方法。 一种抗微生物处理食品的方法。 一种抗微生物涂覆流体容器的方法。 一种抗微生物涂布乳胶医疗制品的方法。

公开(公告)号：WO1997011685A1

公开(公告)日：1997-04-03

申请号：PCT/US1996015649

申请日：1996-09-27

Applicant: EMORY UNIVERSITY ,  WEBER, Collin, J. ,  CHRYSSOCHOOS, John, T. ,  CHAIKOF, Elliot, L.

Inventor： EMORY UNIVERSITY

IPC: A61K09/14

CPC classification number: C12N5/0677 ,  A61K9/5031 ,  A61K9/5073 ,  A61K2035/128

Abstract: The subject invention provides an assay for determining a poly-l-lysine concentration suitable for synthesizing microcapsules having a predetermined permeability which comprises synthesizing a series of microcapsules using different poly-l-lysine concentrations. Accordingly, the subject invention also provides a method of synthesizing microcapsules of a predetermined permeability.

Abstract translation: 本发明提供了一种用于测定适合于合成具有预定渗透性的微胶囊的聚-l-赖氨酸浓度的测定法，其包括使用不同的聚-1-赖氨酸浓度合成一系列微胶囊。 因此，本发明还提供了合成具有预定渗透性的微胶囊的方法。

公开(公告)号：WO1997011607A1

公开(公告)日：1997-04-03

申请号：PCT/US1996015577

申请日：1996-09-27

Applicant: EMORY UNIVERSITY ,  BRISTOL-MYERS SQUIBB COMPANY ,  WEBER, Collin, J. ,  HAGLER, Mary, K. ,  LINSLEY, Peter, S. ,  KAPP, Judith, A.

Inventor： EMORY UNIVERSITY ,  BRISTOL-MYERS SQUIBB COMPANY

IPC: A01N63/00

CPC classification number: C12N5/0677 ,  A61K9/5073 ,  A61K35/39 ,  A61K38/1774 ,  A61K38/28 ,  A61K48/00 ,  C12N5/0676 ,  A61K2300/00

Abstract: This invention provides a method of inhibiting viable cells transplanted into a subject from being destroyed by the subject's immune system which comprises: a) containing the viable cells, or tissue comprising the viable cells, prior to transplantation within a device comprising a semipermeable membrane; and b) treating the subject with a substance which inhibits an immune system costimulation event in an amount effective to inhibit the subject's immune sytem from responding to said contained cells or tissue. In one embodiment, the substance which inhibits an immune system costimulation event is CTLA4. Also provided by this invention is a method of treating diabetes in a subject which comprises: a) containing viable insulin-producing cells, or tissue comprising such cells, within a device comprising a semipermeable membrane; b) transplanting an effective amount of such contained viable insulin-producing cells into the subject; and c) treating the subject with an effective amount of a substance which inhibits an immune system costimulation event.

Abstract translation: 本发明提供一种抑制移植到受试者中的活细胞被受试者的免疫系统破坏的方法，该方法包括：a）在包含半透膜的装置内移植前含有活细胞或包含活细胞的组织; 和b）用抑制免疫系统共刺激事件的物质以有效抑制受试者的免疫系统对所述包含的细胞或组织的反应的物质治疗受试者。 在一个实施方案中，抑制免疫系统共刺激事件的物质是CTLA4。 本发明还提供了一种治疗受试者的糖尿病的方法，其包括：a）在包含半透膜的装置内含有存活的产生胰岛素的细胞或包含此类细胞的组织; b）将有效量的这种含有活体胰岛素的细胞移植到受试者中; 和c）用有效量的抑制免疫系统共刺激事件的物质治疗受试者。

公开(公告)号：WO1997009006A1

公开(公告)日：1997-03-13

申请号：PCT/US1996013907

申请日：1996-08-30

Applicant: EMORY UNIVERSITY

Inventor： EMORY UNIVERSITY ,  WAKSMAN, Ron ,  KING, Spencer, B. ,  SCOTT, Neal, A.

IPC: A61F02/04

CPC classification number: A61F2/07 ,  A61F2/90 ,  A61F2/95 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2250/0067 ,  A61L27/54 ,  A61L2300/412 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/432 ,  A61L2300/602

Abstract: This invention is an endovascular support device (10) adapted for local delivery of a therapeutic agent (50) for minimizing the rate of restenosis having a cylindrical support body (12) with an inside surface (14), an opposite outside surface (16), and at least one layer of pericardial tissue (20) covering at least a portion of at least a selected one of the inside surface (14), or the outside surface (16) of the cylindrical support body (12). At least one therapeutic agent (50) is disposed on a portion of the support device (10).

Abstract translation: 本发明是适于局部递送治疗剂（50）的血管内支持装置（10），用于使具有内表面（14），相对的外表面（16）的具有圆柱形支撑体（12）的再狭窄率最小化， 以及覆盖至少一个所述圆柱形支撑体（12）的内表面（14）或外表面（16）中的一个的至少一部分的心包组织（20）的至少一层。 至少一种治疗剂（50）设置在支撑装置（10）的一部分上。

公开(公告)号：WO1996022778A1

公开(公告)日：1996-08-01

申请号：PCT/US1996000965

申请日：1996-01-29

Applicant: EMORY UNIVERSITY

Inventor： EMORY UNIVERSITY ,  SCHINAZI, Raymond, F. ,  LIOTTA, Dennis, C.

IPC: A61K31/70

CPC classification number: A61K31/7068 ,  A61K31/70 ,  A61K45/06 ,  C07H19/06 ,  A61K2300/00

Abstract: A method and composition for the treatment of HIV an HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a [5-carboxamido or 5-fluoro]-2',3'-dideoxy-2',3'-didehydro-pyrimidine nucleoside or a [5-carboxamido or 5-fluoro]-3'-modified-pyrimidine nucleoside, mixtures thereof, or a pharmaceutically acceptable derivative or derivatives thereof, including an N-1 or N-4 alkylated or acylated derivative, or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier.

Abstract translation: 公开了用于治疗人类和其他宿主动物中的HBV感染的HIV的方法和组合物，其包括给予有效量的[5-甲酰氨基或5-氟] -2'，3'-二脱氧-2' ，3'-二脱氢嘧啶核苷或[5-甲酰氨基或5-氟] -3'-修饰的嘧啶核苷，或其药学上可接受的衍生物或衍生物，包括N-1或N-4烷基化的 或酰化衍生物或其药学上可接受的盐在药学上可接受的载体中。

公开(公告)号：WO1995024427A1

公开(公告)日：1995-09-14

申请号：PCT/US1994013200

申请日：1994-11-15

Applicant: EMORY UNIVERSITY ,  LOLLAR, John, S. ,  RUNGE, Marschall, S.

Inventor： EMORY UNIVERSITY

IPC: C07K14/755

CPC classification number: C07K14/755 ,  A61K38/00 ,  C07K2319/00 ,  Y10S930/10

Abstract: A hybrid procoagulant factor VIII is produced by isolation and recombination of human and other non-human mammalian factor VIII subunits or domains, or by genetic engineering of the human and animal factor VIII genes. Subunits or domains of factor VIII that have been purified from human or animal plasma are isolated, and hybrid human/animal factor VIII is produced by (1) mixing either animal heavy chain subunits with human light chain subunits or by mixing human heavy chain subunits with animal light chain subunits, thereby producing human light chain/animal heavy chain and human heavy chain/animal light chain hybrid molecules; or by (2) mixing one or more domains of one species with one or more domains of the other species. These hybrid molecules are isolated by ion exchange chromatography. Alternatively, recombinant DNA methods are used to change elements of animal factor VIII or human factor VIII to the corresponding elements of human factor VIII or animal factor VIII, respectively, to produce hybrid human/animal factor VIII.

Abstract translation: 通过人和其他非人哺乳动物因子VIII亚基或结构域的分离和重组，或通过人和动物因子VIII基因的遗传工程产生杂交促凝血因子VIII。 分离从人或动物血浆纯化的因子VIII的亚基或结构域，并且通过（1）将动物重链亚基与人轻链亚基混合或通过将人重链亚基与 动物轻链亚基，从而产生人轻链/动物重链和人重链/动物轻链杂交分子; 或（2）将一种物质的一个或多个结构域与其它物种的一个或多个结构域混合。 这些杂化分子通过离子交换色谱分离。 或者，使用重组DNA方法将动物因子VIII或人因子VIII的元件分别改变成人因子VIII或动物因子VIII的相应元件，以产生杂交的人/动物因子VIII。

公开(公告)号：WO1995012310A1

公开(公告)日：1995-05-11

申请号：PCT/US1994012622

申请日：1994-11-02

Applicant: EMORY UNIVERSITY

Inventor： EMORY UNIVERSITY ,  HUNTER, Robert, L.

IPC: A01N01/02

CPC classification number: A01N1/02 ,  A01N1/0226

Abstract: In accordance with the present invention, a composition and method is provided for preserving organs and tissue for transplantation. More particularly, the present invention relates to a method for preserving organs and tissues by perfusing the organ or tissue with a perfusion medium containing an effective amount of a polyoxypropylene/polyoxyethylene surface-active copolymer. The surface-active copolymer may be an ethylene oxide-propylene oxide condensation product with the following general formula (I): HO(C2H4O)b(C3H6O)a(C2H4O)bH, wherein a is an integer such that the hydrophobe represented by (C3H6O) has molecular weight of approximately 950 to 4000 daltons, preferably approximately 1200 to 3500 daltons, and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes approximately 50 % to 90 % by weight of the compound.

Abstract translation: 根据本发明，提供了用于保存移植器官和组织的组合物和方法。 更具体地，本发明涉及通过用含有效量的聚氧丙烯/聚氧乙烯表面活性共聚物的灌注培养基灌注器官或组织来保存器官和组织的方法。 表面活性共聚物可以是具有以下通式（I）的环氧乙烷 - 环氧丙烷缩合产物：HO（C 2 H 4 O）b（C 3 H 6 O）a（C 2 H 4 O）b H，其中a是整数，使得由（ C3H6O）的分子量为约950〜4000道尔顿，优选为1200〜3500道尔顿，b为使（C2H4O）表示的亲水部分构成化合物的约50〜90重量％的整数。

公开(公告)号：WO1995009586A1

公开(公告)日：1995-04-13

申请号：PCT/US1994011098

申请日：1994-09-29

Applicant: EMORY UNIVERSITY ,  GEORGIA TECH RESEARCH CORPORATION

Inventor： EMORY UNIVERSITY ,  GEORGIA TECH RESEARCH CORPORATION ,  CHAIKOF, Elliot, L. ,  LUDOVICE, Peter, J.

IPC: A61F02/06

CPC classification number: A61F2/90 ,  A61F2/07 ,  A61F2002/072 ,  A61F2210/0076 ,  A61F2220/0008

Abstract: This invention relates to a self-expanding intraluminal composite prothesis (10) comprised of a rigid reinforcing component (8) and sealing component (12). The prosthesis may be fabricated as either a straight or bifurcated tubular structure and is applicable to the treatment of any bodily passage including, but not limited to, vascular applications, e.g., aneurysms, arteriovenous fistulas, as well as stenotic regions of the peripheral circulation which have been percutaneously dilated but are at high risk for restenosis. The major attributes of this prosthesis can include the use of a unique multilayered biaxial braid which thereby creates a homogeneously blended composite with isotropic deformation and expansion characteristics and an associated high contraction ratio. The use of multiple layers allows for the fabrication of a device of varied porosity while retaining adequate tensile or mechanical wall strength.

Abstract translation: 本发明涉及由刚性增强部件（8）和密封部件（12）组成的自膨胀管腔内复合材料（10）。 假体可以被制造成直的或分叉的管状结构，并且适用于任何身体通路的治疗，包括但不限于血管应用，例如动脉瘤，动静脉瘘以及周边循环的狭窄区域 已经经皮扩张，但是具有再狭窄的高风险。 该假体的主要特征可以包括使用独特的多层双轴编织物，从而产生具有各向同性变形和膨胀特性和相关联的高收缩率的均匀混合的复合材料。 使用多层允许制造具有不同孔隙率的装置，同时保持足够的拉伸或机械壁强度。

公开(公告)号：WO1994009776A1

公开(公告)日：1994-05-11

申请号：PCT/US1993009457

申请日：1993-10-04

Applicant: OCTAMER, INC. ,  EMORY UNIVERSITY

Inventor： OCTAMER, INC. ,  EMORY UNIVERSITY ,  KUN, Ernest ,  MENDELEYEV, Jerome ,  RICE, William, C.

IPC: A61K31/37

CPC classification number: A61K31/472 ,  A61K31/165 ,  A61K31/166 ,  A61K31/37 ,  A61K31/47 ,  A61K31/4725

Abstract: The subject invention provides for novel compounds for inactivating viruses. These compounds include 6-nitroso-1,2-benzopyrone, 3-nitrosobenzamide, 5-nitroso-1(2H)-isoquinolinone, 7-nitroso-1(2H)-isoquinolinone, 8-nitroso-1(2H)-isoquinolinone. The invention also provides for compositions containing one or more of the compounds, and for methods of treating viral infections, cancer, infectious virus concentration with the subject compounds and compositions.

Abstract translation: 本发明提供了用于灭活病毒的新化合物。 这些化合物包括6-亚硝基-1,2-苯并吡喃酮，3-亚硝基苯甲酰胺，5-亚硝基-1（2H） - 异喹啉酮，7-亚硝基-1（2H） - 异喹啉酮，8-亚硝基-1（2H） - 异喹啉酮。 本发明还提供含有一种或多种化合物的组合物，以及用于治疗病毒感染，癌症，感染性病毒浓度与本发明化合物和组合物的方法的组合物。