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    AMINO ACID PRODUCTION
    2.
    发明申请
    AMINO ACID PRODUCTION 审中-公开
    氨基酸生产

    公开(公告)号：WO2017009009A1

    公开(公告)日：2017-01-19

    申请号：PCT/EP2016/064265

    申请日：2016-06-21

    Applicant: EVONIK DEGUSSA GMBH ,  HAAS, Thomas ,  BECK, Simon ,  BÜLTER, Thomas ,  THIESSENHUSEN, Anja ,  DEMLER, Martin

    Inventor： HAAS, Thomas ,  BECK, Simon ,  BÜLTER, Thomas ,  THIESSENHUSEN, Anja ,  DEMLER, Martin

    IPC: C12P13/06 ,  C12P13/08 ,  C12P13/14 ,  C12P7/06 ,  C12P7/54

    CPC classification number: C12P13/06 ,  C12P7/065 ,  C12P7/54 ,  C12P13/08 ,  C12P13/14 ,  Y02E50/17

    Abstract: The present invention relates to a method of producing at least one amino acid from a carbon source in aerobic conditions, the method comprising: (a)step of producing ethanol and/or acetate from the carbon source in aerobic conditions, comprising (i)contacting a reaction mixture comprising -a first acetogenic microorganism in an exponential growth phase; -free oxygen; and -a second acetogenic microorganism in a stationary phase wherein the first and second acetogenic microorganism is capable of converting the carbon source to the acetate and/or ethanol; and (b)step of contacting the acetate and/or ethanol from step (a) with a third microorganism capable of converting the acetate and/or ethanol to at least one amino acid.

    Abstract translation: 本发明涉及在需氧条件下从碳源生产至少一种氨基酸的方法，所述方法包括：（a）在需氧条件下从碳源生产乙醇和/或乙酸盐的步骤，包括（i） 一种反应混合物，其包含在指数生长期的第一种乙酰酵母微生物; - 无氧; 和 - 在固定相中的第二种致病微生物，其中所述第一和第二产乙酸微生物能够将碳源转化成乙酸盐和/或乙醇; 和（b）使来自步骤（a）的乙酸酯和/或乙醇与能够将乙酸酯和/或乙醇转化为至少一种氨基酸的第三种微生物的步骤。

    RHAMNOLIPID SYNTHESIS
    3.
    发明申请
    RHAMNOLIPID SYNTHESIS 审中-公开
    RHAMNOLIPID合成

    公开(公告)号：WO2016131801A1

    公开(公告)日：2016-08-25

    申请号：PCT/EP2016/053222

    申请日：2016-02-16

    Applicant: EVONIK DEGUSSA GMBH ,  HAAS, Thomas ,  BÜLTER, Thomas ,  BUCHHOLZ, Stefan ,  BECK, Simon

    Inventor： HAAS, Thomas ,  BÜLTER, Thomas ,  BUCHHOLZ, Stefan ,  BECK, Simon

    IPC: C12P19/44 ,  C12N9/10

    CPC classification number: C12P19/44 ,  C12N9/1051 ,  C12N9/14

    Abstract: There is provided a method of producing at least one rhamnolipid comprising: (a) contacting a recombinant cell with a medium containing a carbon source; wherein the recombinant cell has been genetically modified such that, compared to the wild-type of the cell, the cell has an increased activity of at least one of the enzymes E 1 , E 2 and E 3 , wherein the enzyme E 1 is an α/ß hydrolase ( RHIA ), the enzyme E 2 is a rhamnosyltransferase I ( RHIB ) and the enzyme E 3 is a rhamnosyltransferase II ( RHIC ), and wherein the carbon source is an alkane and/or alkanoic acid comprising 6 to 10 carbon atoms.

    Abstract translation: 提供了产生至少一种鼠李糖脂的方法，包括：（a）使重组细胞与含有碳源的培养基接触; 其中所述重组细胞已被遗传修饰，使得与所述细胞的野生型相比，所述细胞具有增加的酶E1，E2和E3中的至少一种的活性，其中所述酶E1是α/β水解酶 （RHIA），酶E2是鼠李糖基转移酶I（RHIB），酶E3是鼠李糖基转移酶II（RHIC），其中碳源是包含6〜10个碳原子的烷烃和/或链烷酸。

    EXTRACTION OF ALKANOIC ACIDS
    4.
    发明申请
    EXTRACTION OF ALKANOIC ACIDS 审中-公开

    公开(公告)号：WO2019158683A1

    公开(公告)日：2019-08-22

    申请号：PCT/EP2019/053786

    申请日：2019-02-15

    Applicant: EVONIK DEGUSSA GMBH

    Inventor： HAAS, Thomas ,  BECK, Simon ,  DEMLER, Martin

    IPC: C07C51/48 ,  C12P7/40 ,  C12P7/62 ,  C12P7/64

    Abstract: The present invention relates to a method of extracting an alkanoic acid and/or ester there of from an aqueous medium, the method comprising : (a)contacting the alkanoic acid and/or ester thereof in the aqueous medium with at least one extracting medium for a time sufficient to extract the alkanoic acid and/or ester thereof from the aqueous medium into the extracting medium, (b)separating the extracting medium with the extracted alkanoic acid and/or ester thereof from the aqueous medium wherein the extracting medium comprises: -a mixture of at least one alkyl-phosphine oxide, preferably Trioctylphosphine oxide (TOPO), and at least one alkane wherein the alkane comprises at least 12 carbon atoms.

    PROCESS FOR PRODUCING ALCOHOLS UNDER AEROBIC CONDITIONS AND PRODUCT EXTRACTION USING OLEYL ALCOHOL
    5.
    发明申请
    PROCESS FOR PRODUCING ALCOHOLS UNDER AEROBIC CONDITIONS AND PRODUCT EXTRACTION USING OLEYL ALCOHOL 审中-公开
    在有氧条件下生产酒精和使用酒精提取产品的方法

    公开(公告)号：WO2018019841A1

    公开(公告)日：2018-02-01

    申请号：PCT/EP2017/068783

    申请日：2017-07-25

    Applicant: EVONIK DEGUSSA GMBH

    Inventor： HECKER, Anja ,  HAAS, Thomas ,  BECK, Simon

    IPC: C12P7/04 ,  C12P7/16 ,  C12P39/00 ,  C07C29/86

    Abstract: The present invention relates to a method of producing at least one alcohol from a carbon source, the method comprising: (a) producing the alcohol in an aqueous medium under aerobic conditions; and (b) extracting the alcohol from step (a) from the aqueous medium by: (bi) contacting the alcohol in the aqueous medium with at least one extracting medium for a time sufficient to extract the alcohol from the aqueous medium into the extracting medium, (bii) separating the extracting medium with the extracted alcohol from the aqueous medium wherein the extracting medium comprises: - oleyl alcohol; or - polypropylene glycol and an alkane wherein the alcohol comprises at least 3 carbon atoms.

    Abstract translation: 本发明涉及从碳源生产至少一种醇的方法，所述方法包括：（a）在需氧条件下在含水介质中生产所述醇; 和（b）通过以下步骤从步骤（a）中提取来自水性介质的醇：（bi）使水性介质中的醇与至少一种提取介质接触足够的时间以将醇从水性介质提取到提取介质中 （bii）将萃取介质与萃取的醇从水性介质中分离，其中萃取介质包含： - 油醇; 或 - 聚丙二醇和烷烃，其中醇包含至少3个碳原子。

    BIOTECHNOLOGICAL PRODUCTION OF PROPANOL AND/OR PROPIONIC ACID
    6.
    发明申请
    BIOTECHNOLOGICAL PRODUCTION OF PROPANOL AND/OR PROPIONIC ACID 审中-公开
    丙醇和/或丙酸的生物技术生产

    公开(公告)号：WO2017202975A1

    公开(公告)日：2017-11-30

    申请号：PCT/EP2017/062642

    申请日：2017-05-24

    Applicant: EVONIK DEGUSSA GMBH

    Inventor： HAAS, Thomas ,  BECK, Simon ,  HECKER, Anja

    IPC: C12P7/04 ,  C12P7/52

    Abstract: The present invention relates to a method of producing propanol and/or propionic acid, the method comprising: (b) contacting at least one propionogen to carbon dioxide and to an aqueous medium comprising ethanol and acetate; wherein the acetate is maintained at a concentration of at least about 1 g/L in the aqueous medium.

    Abstract translation: 本发明涉及一种生产丙醇和/或丙酸的方法，所述方法包括：（b）使至少一种丙酸盐与二氧化碳和包含乙醇和乙酸盐的水性介质接触; 其中乙酸盐在含水介质中保持在至少约1g / L的浓度。

    N-ACETYL HOMOSERINE
    8.
    发明申请
    N-ACETYL HOMOSERINE 审中-公开

    公开(公告)号：WO2018019867A1

    公开(公告)日：2018-02-01

    申请号：PCT/EP2017/068841

    申请日：2017-07-26

    Applicant: EVONIK DEGUSSA GMBH

    Inventor： HAAS, Thomas ,  SCHAFFER, Steffen ,  BÜLTER, Thomas ,  BECK, Simon

    IPC: C07C233/47 ,  C12P13/06

    Abstract: The present invention relates to a compound of general formula (I). The present invention also relates to a method of producing N-acetyl homoserine and/or derivatives thereof, the method comprising contacting at least one recombinant cell in an aqueous medium with acetate wherein the recombinant cell comprises an increased activity relative to a wild type cell of (a) an enzyme E 1 ,a homoserine dehydrogenase (EC1.1.1.3) and/or an enzyme E 5 , an aspartokinase (EC2.7.2.4); and (b) an enzyme E 2 , a homoserine O-acetyl transferase (EC2.3.1.31) and the acetate is maintained at a concentration of at least about 0.001 g/L in the aqueous medium.

    Abstract translation: 本发明涉及通式（I）的化合物。 本发明还涉及产生N-乙酰高丝氨酸和/或其衍生物的方法，所述方法包括使至少一种重组细胞在水性介质中与乙酸盐接触，其中所述重组细胞相对于野生型细胞包含 （a）酶E1，高丝氨酸脱氢酶（EC1.1.1.3）和/或酶E5，天冬氨酸激酶（EC2.7.2.4）; 和（b）酶E 2，高丝氨酸O-乙酰基转移酶（EC 2.3.1.31），并且乙酸盐在含水介质中保持在至少约0.001g / L的浓度。

    PROCESS FOR PRODUCING ALCOHOLS UNDER AEROBIC CONDITIONS AND PRODUCT EXTRACTION USING A MIXTURE OF POLYPROPYLENE GLYCOL AND ALKANE
    9.
    发明申请
    PROCESS FOR PRODUCING ALCOHOLS UNDER AEROBIC CONDITIONS AND PRODUCT EXTRACTION USING A MIXTURE OF POLYPROPYLENE GLYCOL AND ALKANE 审中-公开
    在有利条件下生产醇和使用聚丙二醇和烷烃的混合物进行产物提取的方法

    公开(公告)号：WO2018019847A1

    公开(公告)日：2018-02-01

    申请号：PCT/EP2017/068792

    申请日：2017-07-25

    Applicant: EVONIK DEGUSSA GMBH

    Inventor： HECKER, Anja ,  HAAS, Thomas ,  BECK, Simon

    IPC: C12P7/04 ,  C12P7/16 ,  C12P39/00 ,  C07C29/86

    Abstract: The present invention relates to a method of producing at least one alcohol from a carbon source, the method comprising: (a) producing the alcohol in an aqueous medium under aerobic conditions; and (b) extracting the alcohol from step (a) from the aqueous medium by: (bi) contacting the alcohol in the aqueous medium with at least one extracting medium for a time sufficient to extract the alcohol from the aqueous medium into the extracting medium, (bii )separating the extracting medium with the extracted alcohol from the aqueous medium wherein the extracting medium comprises: -oleyl alcohol; or -polypropylene glycol and an alkane wherein the alcohol comprises at least 3 carbon atoms.

    Abstract translation: 本发明涉及从碳源生产至少一种醇的方法，所述方法包括：（a）在需氧条件下在含水介质中生产所述醇; 和（b）通过以下步骤从步骤（a）中提取来自水性介质的醇：（bi）使水性介质中的醇与至少一种提取介质接触足够的时间以将醇从水性介质提取到提取介质中 （bii）将萃取介质与萃取的醇从水性介质中分离，其中萃取介质包含： - 油醇; 或 - 聚丙二醇和其中醇包含至少3个碳原子的烷烃。

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