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    A GENETICALLY MODIFIED ACETOGENIC CELL
    1.
    发明申请
    A GENETICALLY MODIFIED ACETOGENIC CELL 审中-公开
    一种遗传修饰的致敏细胞

    公开(公告)号：WO2017102952A1

    公开(公告)日：2017-06-22

    申请号：PCT/EP2016/081202

    申请日：2016-12-15

    Applicant: EVONIK DEGUSSA GMBH

    Inventor： HAAS, Thomas ,  BÜLTER, Thomas ,  THIESSENHUSEN, Anja

    IPC: C12N9/10 ,  C12P7/04

    CPC classification number: C12P7/16 ,  Y02E50/10

    Abstract: There is provided an acetogenic microbial cell which is capable of producing at least one higher alcohol from a carbon source, wherein the acetogenic microbial cell is genetically modified to comprise an increased expression relative to its wild type cell of at least one enzyme, E 8 , a butyryl-CoA: acetate CoA transferase (cat3). There is also provided a method and use of the cell to produce higher alcohols.

    Abstract translation: 提供了能够从碳源生产至少一种高级醇的产乙酸微生物细胞，其中产乙酸微生物细胞被遗传修饰以包含相对于其野生型细胞的增加的表达 至少一种酶E8：丁酰-CoA：乙酸CoA转移酶（cat3）。 还提供了细胞生产高级醇的方法和用途。

    METHIONINE PRODUCTION
    2.
    发明申请
    METHIONINE PRODUCTION 审中-公开
    蛋氨酸生产

    公开(公告)号：WO2017191196A1

    公开(公告)日：2017-11-09

    申请号：PCT/EP2017/060553

    申请日：2017-05-03

    Applicant: EVONIK DEGUSSA GMBH

    Inventor： HAAS, Thomas ,  THIESSENHUSEN, Anja ,  RICHTER, Christian ,  BÜLTER, Thomas

    IPC: C07C319/18 ,  C07C319/20 ,  C07C323/58

    Abstract: There is provided a method of producing a method of producing methionine, the method comprising - contacting vinylglycine or derivatives thereof with at least one free radical methyl mercaptanin a reaction medium.

    Abstract translation: 提供了生产甲硫氨酸的方法的方法，所述方法包括 - 使乙烯基甘氨酸或其衍生物与至少一种自由基甲基硫醇在反应介质中接触。

    AMINO ACID PRODUCTION
    3.
    发明申请
    AMINO ACID PRODUCTION 审中-公开
    氨基酸生产

    公开(公告)号：WO2017009009A1

    公开(公告)日：2017-01-19

    申请号：PCT/EP2016/064265

    申请日：2016-06-21

    Applicant: EVONIK DEGUSSA GMBH ,  HAAS, Thomas ,  BECK, Simon ,  BÜLTER, Thomas ,  THIESSENHUSEN, Anja ,  DEMLER, Martin

    Inventor： HAAS, Thomas ,  BECK, Simon ,  BÜLTER, Thomas ,  THIESSENHUSEN, Anja ,  DEMLER, Martin

    IPC: C12P13/06 ,  C12P13/08 ,  C12P13/14 ,  C12P7/06 ,  C12P7/54

    CPC classification number: C12P13/06 ,  C12P7/065 ,  C12P7/54 ,  C12P13/08 ,  C12P13/14 ,  Y02E50/17

    Abstract: The present invention relates to a method of producing at least one amino acid from a carbon source in aerobic conditions, the method comprising: (a)step of producing ethanol and/or acetate from the carbon source in aerobic conditions, comprising (i)contacting a reaction mixture comprising -a first acetogenic microorganism in an exponential growth phase; -free oxygen; and -a second acetogenic microorganism in a stationary phase wherein the first and second acetogenic microorganism is capable of converting the carbon source to the acetate and/or ethanol; and (b)step of contacting the acetate and/or ethanol from step (a) with a third microorganism capable of converting the acetate and/or ethanol to at least one amino acid.

    Abstract translation: 本发明涉及在需氧条件下从碳源生产至少一种氨基酸的方法，所述方法包括：（a）在需氧条件下从碳源生产乙醇和/或乙酸盐的步骤，包括（i） 一种反应混合物，其包含在指数生长期的第一种乙酰酵母微生物; - 无氧; 和 - 在固定相中的第二种致病微生物，其中所述第一和第二产乙酸微生物能够将碳源转化成乙酸盐和/或乙醇; 和（b）使来自步骤（a）的乙酸酯和/或乙醇与能够将乙酸酯和/或乙醇转化为至少一种氨基酸的第三种微生物的步骤。

    A METHOD OF PRODUCING ALPHA AMINO ACIDS
    4.
    发明申请
    A METHOD OF PRODUCING ALPHA AMINO ACIDS 审中-公开
    生产氨基酸的方法

    公开(公告)号：WO2016184656A1

    公开(公告)日：2016-11-24

    申请号：PCT/EP2016/059486

    申请日：2016-04-28

    Applicant: EVONIK DEGUSSA GMBH ,  DENNIG, Alexander ,  FABER, Kurt ,  HALL, Mélanie ,  HAAS, Thomas ,  BÜLTER, Thomas ,  GILCH, Stefan ,  THIESSENHUSEN, Anja

    Inventor： DENNIG, Alexander ,  FABER, Kurt ,  HALL, Mélanie ,  HAAS, Thomas ,  BÜLTER, Thomas ,  GILCH, Stefan ,  THIESSENHUSEN, Anja

    IPC: C12P13/00 ,  C12P13/06 ,  C12N1/21

    CPC classification number: C12P13/04 ,  C12N9/0006 ,  C12N9/0016 ,  C12N9/0065 ,  C12P13/06

    Abstract: The present invention provides a microbial cell capable of producing at least one alpha amino acid from at least oneshort chain fatty acid, wherein the cell is genetically modified to comprise - at least a first genetic mutation that increases the expression relative to the wild type cell of an enzyme E 1 capable of catalysing the hydroxylation of the fatty acid to an alpha-hydroxy fatty acid, - at least a second genetic mutation that increases the expression relative to the wild type cell of an enzyme E 2 capable of catalysing the oxidation of the an alpha-hydroxy fatty acid to an alpha ketone, and - at least a third genetic mutation that increases the expression relative to the wild type cell of enzyme E 3 capable of catalysing the oxidation of the alpha ketone to an alpha amino acid wherein the short chain fatty acid is a C 4 -C 10 fatty acid.

    Abstract translation: 本发明提供一种能够从至少一种单链脂肪酸产生至少一种α氨基酸的微生物细胞，其中所述细胞被遗传修饰为包括至少第一种遗传突变，其增加相对于野生型细胞的表达 能够催化脂肪酸羟基化为α-羟基脂肪酸的酶E1， - 至少第二种遗传突变，其增加相对于能够催化α的氧化的酶E2的野生型细胞的表达 - 羟基脂肪酸与α-酮的相互作用，以及至少第三种遗传突变，其增加相对于能够催化α酮氧化成α型氨基酸的酶E3的野生型细胞的表达，其中短链脂肪酸 是C4-C10脂肪酸。

    RHAMNOLIPID SYNTHESIS
    5.
    发明申请
    RHAMNOLIPID SYNTHESIS 审中-公开
    RHAMNOLIPID合成

    公开(公告)号：WO2016131801A1

    公开(公告)日：2016-08-25

    申请号：PCT/EP2016/053222

    申请日：2016-02-16

    Applicant: EVONIK DEGUSSA GMBH ,  HAAS, Thomas ,  BÜLTER, Thomas ,  BUCHHOLZ, Stefan ,  BECK, Simon

    Inventor： HAAS, Thomas ,  BÜLTER, Thomas ,  BUCHHOLZ, Stefan ,  BECK, Simon

    IPC: C12P19/44 ,  C12N9/10

    CPC classification number: C12P19/44 ,  C12N9/1051 ,  C12N9/14

    Abstract: There is provided a method of producing at least one rhamnolipid comprising: (a) contacting a recombinant cell with a medium containing a carbon source; wherein the recombinant cell has been genetically modified such that, compared to the wild-type of the cell, the cell has an increased activity of at least one of the enzymes E 1 , E 2 and E 3 , wherein the enzyme E 1 is an α/ß hydrolase ( RHIA ), the enzyme E 2 is a rhamnosyltransferase I ( RHIB ) and the enzyme E 3 is a rhamnosyltransferase II ( RHIC ), and wherein the carbon source is an alkane and/or alkanoic acid comprising 6 to 10 carbon atoms.

    Abstract translation: 提供了产生至少一种鼠李糖脂的方法，包括：（a）使重组细胞与含有碳源的培养基接触; 其中所述重组细胞已被遗传修饰，使得与所述细胞的野生型相比，所述细胞具有增加的酶E1，E2和E3中的至少一种的活性，其中所述酶E1是α/β水解酶 （RHIA），酶E2是鼠李糖基转移酶I（RHIB），酶E3是鼠李糖基转移酶II（RHIC），其中碳源是包含6〜10个碳原子的烷烃和/或链烷酸。

    PRODUCTION OF PROPANOL AND/OR PROPIONIC ACID
    7.
    发明申请
    PRODUCTION OF PROPANOL AND/OR PROPIONIC ACID 审中-公开
    丙二醇和/或丙酸的生产

    公开(公告)号：WO2017025344A1

    公开(公告)日：2017-02-16

    申请号：PCT/EP2016/068036

    申请日：2016-07-28

    Applicant: EVONIK DEGUSSA GMBH

    Inventor： HAAS, Thomas ,  BECK, Simon ,  DEMLER, Martin ,  BÜLTER, Thomas

    IPC: C12P7/04 ,  C12P7/52 ,  C12P39/00

    CPC classification number: C12P7/04 ,  C12P7/52 ,  C12P39/00

    Abstract: The present invention relates to a method of producing propanol and/or propionic acid from a carbon source in aerobic conditions, the method comprising: (a) step of producing ethanol and/or acetate from the carbon source in aerobic conditions, comprising (i) contacting a reaction mixture comprising a first acetogenic microorganism in an exponential growth phase; free oxygen; and a second acetogenic microorganism in a stationary phase wherein the first and second acetogenic microorganism is capable of converting the carbon source to the acetate and/or ethanol; and (b) step of contacting the acetate and/or ethanol from step (a) with a third microorganism capable of converting the acetate and/or ethanol to propanol and/or propionic acid.

    Abstract translation: 本发明涉及在需氧条件下从碳源生产丙醇和/或丙酸的方法，所述方法包括：（a）在需氧条件下从碳源生产乙醇和/或乙酸酯的步骤，包括（i） 使包含指数生长期的第一产乙酸微生物的反应混合物接触; 游离氧气 和第二种致病微生物在固定相中，其中第一和第二产乙酸微生物能够将碳源转化成乙酸盐和/或乙醇; 和（b）使来自步骤（a）的乙酸酯和/或乙醇与能够将乙酸酯和/或乙醇转化为丙醇和/或丙酸的第三种微生物的步骤。

    METHIONINE PRODUCTION
    8.
    发明申请
    METHIONINE PRODUCTION 审中-公开
    甲硫氨酸生产

    公开(公告)号：WO2016184663A1

    公开(公告)日：2016-11-24

    申请号：PCT/EP2016/059619

    申请日：2016-04-29

    Applicant: EVONIK DEGUSSA GMBH ,  HAAS, Thomas ,  BÜLTER, Thomas ,  THIESSENHUSEN, Anja

    Inventor： HAAS, Thomas ,  BÜLTER, Thomas ,  THIESSENHUSEN, Anja

    IPC: C12N15/52 ,  C12R1/00

    CPC classification number: C12N9/0071 ,  C12N9/00 ,  C12P7/16 ,  C12P7/52 ,  C12P7/62 ,  C12P13/06 ,  C12P39/00 ,  C12Y114/14001 ,  Y02E50/10

    Abstract: The present invention relates to a microbial cell capable of producing at least one acetylhomoserine from 4-acetyl-butyric acid and/or ester thereof, wherein the cell is genetically modified to comprise -at least a first genetic mutation that increases the expression relative to the wild type cell of an enzyme E 1 capable of catalysing the hydroxylation of 4-acetyl-butyric acid and/or ester thereof to an alpha-hydroxy acetyl butanone, and -at least a second genetic mutation that increases the expression relative to the wild type cell of enzyme E 2 capable of catalysing the amination of the alpha-hydroxy acetyl butanone to the acetylhomoserine.

    Abstract translation: 本发明涉及能够从4-乙酰基 - 丁酸和/或其酯产生至少一种乙酰高丝氨酸的微生物细胞，其中所述细胞被遗传修饰为包括至少增加相对于 能够催化4-乙酰基 - 丁酸和/或其酯对α-羟基乙酰丁酮羟基化的酶E1的野生型细胞，和至少增加相对于野生型细胞的表达的第二种遗传突变 的能够催化α-羟基乙酰丁酮胺化成乙酰高丝氨酸的酶E2。

    N-ACETYL HOMOSERINE
    10.
    发明申请
    N-ACETYL HOMOSERINE 审中-公开

    公开(公告)号：WO2018019867A1

    公开(公告)日：2018-02-01

    申请号：PCT/EP2017/068841

    申请日：2017-07-26

    Applicant: EVONIK DEGUSSA GMBH

    Inventor： HAAS, Thomas ,  SCHAFFER, Steffen ,  BÜLTER, Thomas ,  BECK, Simon

    IPC: C07C233/47 ,  C12P13/06

    Abstract: The present invention relates to a compound of general formula (I). The present invention also relates to a method of producing N-acetyl homoserine and/or derivatives thereof, the method comprising contacting at least one recombinant cell in an aqueous medium with acetate wherein the recombinant cell comprises an increased activity relative to a wild type cell of (a) an enzyme E 1 ,a homoserine dehydrogenase (EC1.1.1.3) and/or an enzyme E 5 , an aspartokinase (EC2.7.2.4); and (b) an enzyme E 2 , a homoserine O-acetyl transferase (EC2.3.1.31) and the acetate is maintained at a concentration of at least about 0.001 g/L in the aqueous medium.

    Abstract translation: 本发明涉及通式（I）的化合物。 本发明还涉及产生N-乙酰高丝氨酸和/或其衍生物的方法，所述方法包括使至少一种重组细胞在水性介质中与乙酸盐接触，其中所述重组细胞相对于野生型细胞包含 （a）酶E1，高丝氨酸脱氢酶（EC1.1.1.3）和/或酶E5，天冬氨酸激酶（EC2.7.2.4）; 和（b）酶E 2，高丝氨酸O-乙酰基转移酶（EC 2.3.1.31），并且乙酸盐在含水介质中保持在至少约0.001g / L的浓度。

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