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公开(公告)号：WO2020035425A1
公开(公告)日：2020-02-20
申请号：PCT/EP2019/071522
申请日：2019-08-12
发明人： ANSELM, Lilli , BENZ, Joerg , GRETHER, Uwe , GROEBKE ZBINDEN, Katrin , HEER, Dominik , HORNSPERGER, Benoit , KROLL, Carsten , KUHN, Bernd , O`HARA, Fionn , RICHTER, Hans
IPC分类号： C07D498/04 , A61K31/5365 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/28 , A61P25/24 , A61P35/00
摘要： The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R 1 and R 2 are as described herein, compositions including the compounds, processes of manufacturing the compounds, methods of using the compounds and methods of determining the monoacylglycerol lipase (MAGL) inhibitory activity of the compounds.
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公开(公告)号：WO2014029722A1
公开(公告)日：2014-02-27
申请号：PCT/EP2013/067218
申请日：2013-08-19
发明人： ANSELM, Lilli , BANNER, David , HAAP, Wolfgang , KUHN, Bernd , LUEBBERS, Thomas , PETERS, Jens-Uwe , SPINNLER, Beat
IPC分类号： C07D401/14 , A61K31/4439 , A61K31/444
CPC分类号： C07D401/08 , A61K9/2054 , A61K9/4858 , C07D401/14
摘要： The invention relates to a compound of formula (I) wherein A 1 , A 2 and R 1 to R 6 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
摘要翻译： 本发明涉及式（I）化合物，其中A1，A2和R1至R6如在说明书和权利要求书中所定义。 式（I）化合物可以用作药物。
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公开(公告)号：WO2016023927A1
公开(公告)日：2016-02-18
申请号：PCT/EP2015/068506
申请日：2015-08-12
发明人： ANSELM, Lilli , BARTELS, Bjoern , DOLENTE, Cosimo , GUBA, Wolfgang , HAAP, Wolfgang , PETERS, Jens-Uwe , WOLTERING, Thomas , OBST SANDER, Ulrike , ROGERS-EVANS, Mark
IPC分类号： C07D403/12 , A61K45/06 , A61K31/54
CPC分类号： C07D403/12
摘要： The present invention provides a compound of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
摘要翻译： 本发明提供具有BACE1抑制活性的式（I）化合物，其制备方法，含有它们的药物组合物及其作为治疗活性物质的用途。 本发明的活性化合物可用于例如治疗和/或预防性治疗。 阿尔茨海默氏病。
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4.发明申请
公开(公告)号：WO2007057317A1
公开(公告)日：2007-05-24
申请号：PCT/EP2006/068138
申请日：2006-11-06
申请人： F. HOFFMANN-LA ROCHE AG , ANSELM, Lilli , GROEBKE ZBINDEN, Katrin , HAAP, Wolfgang , HILPERT, Hans , HIMBER, Jacques , KUHN, Bernd , PANDAY, Narendra , RICKLIN, Fabienne , THOMI, Stefan
发明人： ANSELM, Lilli , GROEBKE ZBINDEN, Katrin , HAAP, Wolfgang , HILPERT, Hans , HIMBER, Jacques , KUHN, Bernd , PANDAY, Narendra , RICKLIN, Fabienne , THOMI, Stefan
IPC分类号： C07D409/14 , A61K31/4439 , A61P7/00
CPC分类号： C07D409/14 , C07D413/14
摘要： The invention is concerned with novel pyrrolidine derivatives of formula (I) wherein X, Y, R 1 , R 2 and R 3 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
摘要翻译： 本发明涉及式（I）的新型吡咯烷衍生物，其中X，Y，R 1，R 2和R 3定义如上 在说明书和权利要求书中，以及其生理上可接受的盐。 这些化合物抑制凝血因子Xa并可用作药物。
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公开(公告)号：WO2005092881A1
公开(公告)日：2005-10-06
申请号：PCT/EP2005/002862
申请日：2005-03-17
申请人： F. HOFFMANN-LA ROCHE AG , ANSELM, Lilli , GROEBKE ZBINDEN, Katrin , HAAP, Wolfgang , HIMBER, Jacques , STAHL, Christoph, Martin , THOMI, Stefan
发明人： ANSELM, Lilli , GROEBKE ZBINDEN, Katrin , HAAP, Wolfgang , HIMBER, Jacques , STAHL, Christoph, Martin , THOMI, Stefan
IPC分类号： C07D401/12
CPC分类号： C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12
摘要： The invention is concerned with novel pyrrolidine-3,4-dicarboxamide derivatives of Formula (I) ; wherein R l to R 9 and X are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
摘要翻译： 本发明涉及式（I）的新型吡咯烷-3,4-二甲酰胺衍生物; 其中R 1至R 9和X如说明书和权利要求书中所定义，以及其生理上可接受的盐。 这些化合物抑制凝血因子Xa，并且可以用作药物。
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公开(公告)号：WO2013104613A1
公开(公告)日：2013-07-18
申请号：PCT/EP2013/050204
申请日：2013-01-08
申请人： F. HOFFMANN-LA ROCHE AG , ANSELM, Lilli , BANNER, David , BLANC, Jean-Baptiste , GAUFRETEAU, Delphine , HAAP, Wolfgang , HARTMANN, Guido , KUHN, Bernd , LUEBBERS, Thomas , PETERS, Jens-Uwe , SPINNLER, Beat
发明人： ANSELM, Lilli , BANNER, David , BLANC, Jean-Baptiste , GAUFRETEAU, Delphine , HAAP, Wolfgang , HARTMANN, Guido , KUHN, Bernd , LUEBBERS, Thomas , PETERS, Jens-Uwe , SPINNLER, Beat
IPC分类号： C07D498/08 , C07D498/18 , C07D498/22 , C07D515/08 , C07D515/22 , C07D273/01 , A61K31/395 , A61K31/407 , A61K31/4353 , A61K31/397 , A61P3/10
CPC分类号： C07D273/01 , C07D269/00 , C07D273/02 , C07D413/10 , C07D498/06 , C07D498/08 , C07D498/18 , C07D498/22 , C07D515/06 , C07D515/08 , C07D515/22
摘要： The invention relates to a compound of formula (I) wherein A, B, D and R 1 to R 6 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
摘要翻译： 本发明涉及式（I）化合物，其中A，B，D和R 1至R 6如在说明书和权利要求书中所定义。 式（I）化合物可以用作药物。
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