公开(公告)号：WO2019145863A1

公开(公告)日：2019-08-01

申请号：PCT/IB2019/050552

申请日：2019-01-23

Applicant: FIDIA FARMACEUTICI S.P.A.

Inventor： PASTORELLO, Andrea ,  BETTELLA, Flavio ,  GALESSO, Devis

IPC: A61K9/00 ,  A61K47/36

Abstract: Disclosed are pharmaceutical compositions in gel form comprising a hydrophilic matrix consisting of a hyaluronic acid derivative containing an amide local anaesthetic in base form.

公开(公告)号：WO2008031525A1

公开(公告)日：2008-03-20

申请号：PCT/EP2007/007758

申请日：2007-09-05

Applicant: FIDIA FARMACEUTICI S.P.A. ,  CRESCENZI, Vittorio ,  DI MEO, Chiara ,  GALESSO, Devis

Inventor： CRESCENZI, Vittorio ,  DI MEO, Chiara ,  GALESSO, Devis

IPC: C08B37/00 ,  A61L27/52 ,  A61K47/36

CPC classification number: A61L27/52 ,  A61K9/0014 ,  A61K9/06 ,  A61K47/36 ,  A61L27/20 ,  C08B37/0072 ,  C08L5/08

Abstract: Crosslinked derivatives of polycarboxylated polysaccharides are described, wherein at least one of the polysaccharide chains consists of hyaluronic acid or a derivative thereof, crosslinked by means of reactions of the "click chemistry" type and their use in the field of viscosupplementation, plastic surgery, oncologic and reconstructive surgery and also as matrices for controlled release systems of biologically and/or pharmacologically active molecules and/or macromolecules.

Abstract translation: 描述了多羧化多糖的交联衍生物，其中至少一个多糖链由透明质酸或其衍生物组成，通过“点击化学”类型的反应及其在粘弹性补充领域，整形外科，肿瘤学中的应用而交联 和重建手术，还可以作为生物和/或药理学活性分子和/或大分子的控制释放系统的基质。

公开(公告)号：WO2006122638A1

公开(公告)日：2006-11-23

申请号：PCT/EP2006/003898

申请日：2006-04-21

Applicant: FIDIA FARMACEUTICI S.p.A. ,  CALLEGARO, Lanfranco ,  GALESSO, Devis ,  TAGLIENTI, Anna

Inventor： CALLEGARO, Lanfranco ,  GALESSO, Devis ,  TAGLIENTI, Anna

IPC: A61K8/14 ,  A61K8/73 ,  A61Q19/00 ,  A61Q19/08 ,  A61F2/10 ,  A61K9/127

CPC classification number: A61K8/553 ,  A61K8/14 ,  A61K8/735 ,  A61K9/0024 ,  A61K9/127 ,  A61Q19/00

Abstract: The present invention describes a new bioresorbable filler constituted by hyaluronic acid and/or the derivatives thereof structured with/ in phospholipid liposomes, which increase the residence time of the starting polymer in situ. Said fillers described herein are substantially intended to increase the soft tissues in aesthetic surgery and dermocosmetics for the correction of mild to medium defects, but because of their special characteristics they can also be used in other fields of application.

Abstract translation: 本发明描述了由/由磷脂脂质体构建的由透明质酸和/或其衍生物构成的新的生物可吸收填料，其增加了起始聚合物原位停留时间。 本文所述的所述填料基本上旨在增加美学手术中的软组织和用于矫正轻度至中度缺陷的皮肤用品，但由于其特殊特性，它们也可用于其它应用领域。

公开(公告)号：WO2021186335A1

公开(公告)日：2021-09-23

申请号：PCT/IB2021/052160

申请日：2021-03-16

Applicant: FIDIA FARMACEUTICI S.P.A.

Inventor： GALESSO, Devis ,  BENINATTO, Carlo ,  PAVAN, Mauro ,  DI LUCIA, Alba

IPC: C08B37/08 ,  A61K38/39 ,  C07K14/78

Abstract: A bio-ink for use in 3D printing, the related conjugate and the preparation process of an intermediate consisting of a bifunctional photoreactive linker are described. Said bio-inks are used for the manufacturing of constructs by 3D printing.

公开(公告)号：WO2018092013A1

公开(公告)日：2018-05-24

申请号：PCT/IB2017/057070

申请日：2017-11-13

Applicant: FIDIA FARMACEUTICI S.P.A.

Inventor： GUARISE, Cristian ,  PLUDA, Stefano ,  GALESSO, Devis

IPC: C08B37/08 ,  A61K47/36 ,  A61K31/727

Abstract: Disclosed is grade 2 sulphated hyaluronic acid having 2 to 60 % molar, preferably 15 to 35%), and even more preferably between 20 and 25 %, of the carboxyl groups functionalized with dopamine conjugated directly via an amide bond or by means of a spacer having an amino group for the formation of an amide bond with the carboxyl groups of hyaluronic acid and of a carboxyl group for the formation of an amide bond with the amino group of dopamine.

公开(公告)号：WO2012110456A1

公开(公告)日：2012-08-23

申请号：PCT/EP2012/052412

申请日：2012-02-13

Applicant: FIDIA FARMACEUTICI S.p.A. ,  PASTORELLO, Andrea ,  GALESSO, Devis ,  BETTELLA, Fabio

Inventor： PASTORELLO, Andrea ,  GALESSO, Devis ,  BETTELLA, Fabio

IPC: A61K9/14 ,  A61K31/192 ,  A61K31/196 ,  A61K31/717 ,  A61K31/729 ,  A61K33/38 ,  A61P29/00 ,  A61P43/00

CPC classification number: A61K31/738 ,  A61K9/0014 ,  A61K9/146 ,  A61K31/192 ,  A61K31/196 ,  A61K31/717 ,  A61K31/728 ,  A61K31/729 ,  A61K33/38 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention discloses pharmaceutical compositions in the form of a dusting powder or dry spray, possessing a high absorbent capacity, painkilling activity and wound-healing action, which compositions consist of croscarmellose sodium, a non-steroidal anti-inflammatory drug (NSAID) and hyaluronic acid, and optionally also contain other pharmacologically active substances and/or excipients. The compositions disclosed herein are suitable for use in the treatment of skin lesions wherein the presence of exudate limits wound healing and causes pain; they are therefore particularly suitable for chronic ulcerous skin lesions of various origins and burns.

Abstract translation: 本发明公开了具有高吸收能力，止痛活性和伤口愈合作用的粉剂或干喷雾形式的药物组合物，该组合物由交联羧甲纤维素钠，非甾体抗炎药（NSAID）和透明质酸 酸，并且任选地还含有其它药理活性物质和/或赋形剂。 本文公开的组合物适用于治疗皮肤病变，其中渗出液的存在限制伤口愈合并引起疼痛; 因此它们特别适用于各种起源和灼伤的慢性溃疡性皮肤病变。

公开(公告)号：WO2010130466A1

公开(公告)日：2010-11-18

申请号：PCT/EP2010/003044

申请日：2010-05-11

Applicant: FIDIA FARMACEUTICI S.p.A. ,  GALESSO, Devis ,  ZANELLATO, Anna Maria

Inventor： GALESSO, Devis ,  ZANELLATO, Anna Maria

IPC: A61K31/737 ,  A61P11/06 ,  A61P17/00 ,  A61P19/02 ,  A61P31/18 ,  A61P31/22 ,  A61P35/00 ,  A61P37/00

CPC classification number: A61K31/737

Abstract: The object of the present invention relates to the new and surprising use of sulfated hyaluronic acid (HAS) as regulator agent of the cytokine activity (pro- and anti- inflammatory) and consequently the use of HAS for the preparation of a new medicine for the prevention and treatment of pathologies associated with the activation and/or deficiency of cytokines of a pro- and anti- inflammatory nature. The Applicant has in fact discovered its exclusive capacity in modulating the activity of these particular proteins, it has studied the action mechanism and demonstrated the substantial difference between the different sulfated types known in the state of the art, but above all it has demonstrated an unexpectedly high activity of HAS vs different types and strains of Herpes virus, HIV, Cytomegalovirus and the virus of vesicular stomatitis.

Abstract translation: 本发明的目的涉及硫酸化透明质酸（HAS）作为细胞因子活性（促炎和抗炎）的调节剂的新的和令人惊奇的用途，因此使用HAS制备用于 预防和治疗与促炎和抗炎性质的细胞因子的活化和/或缺乏相关的病理学。 申请人实际上已经发现其调节这些特定蛋白质的活性的独特能力，已经研究了作用机制，并证明了现有技术中已知的不同硫酸化类型之间的显着差异，但首先它已经显示出了意想不到的 HAS对不同类型和疱疹病毒，HIV，巨细胞病毒和水泡性口炎病毒的高活性。