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    DRY GRANULATION BINDERS, PRODUCTS, AND USE THEREOF
    6.
    发明申请
    DRY GRANULATION BINDERS, PRODUCTS, AND USE THEREOF 审中-公开
    干燥颗粒结合剂，产品及其用途

    公开(公告)号：WO2008057266A2

    公开(公告)日：2008-05-15

    申请号：PCT/US2007/022684

    申请日：2007-10-26

    Applicant: FMC CORPORATION ,  THOORENS, Gregory ,  LECLERCQ, Bruno ,  CARLIN, Brian ,  RILEY, Peter, J. ,  GARCIA, Miguel, Angel

    Inventor： THOORENS, Gregory ,  LECLERCQ, Bruno ,  CARLIN, Brian ,  RILEY, Peter, J. ,  GARCIA, Miguel, Angel

    IPC: A61K9/16

    CPC classification number: A61K9/1623 ,  A61K9/1652 ,  A61K9/1682 ,  A61K9/2018 ,  A61K9/2054

    Abstract: A method for the preparation of microcrystalline cellulose containing tablets by roller compaction followed by tabletting is disclosed. A tablet formulation is converted to a dry granulate by roller compaction, and the dry granulate lubricated dry granulate and compacted to a tablet. The tablet formulation comprises at least one active, an microcrystalline cellulose containing material, and, optionally other pharmaceutically acceptable excipients. The microcrystalline cellulose containing material has a maximum primary compaction tensile strength of at least 9 MPa or at least 9.5 MPa and a secondary compaction tensile strength of at least 5 MPa, at least 5.5 MPa, or at least 6 MPa.

    Abstract translation: 公开了一种通过碾压和压片制备含微晶纤维素片剂的方法。 通过碾压将片剂制剂转化为干燥的颗粒，干燥的颗粒润滑干燥的颗粒并压制成片剂。 该片剂制剂包含至少一种活性物质，含微晶纤维素的物质和任选的其它药学上可接受的赋形剂。 含微晶纤维素材料具有至少9MPa或至少9.5MPa的最大一次压缩抗拉强度和至少5MPa，至少5.5MPa或至少6MPa的二次压缩抗拉强度。

    GELLED COMPOSITE
    9.
    发明申请
    GELLED COMPOSITE 审中-公开
    凝胶复合材料

    公开(公告)号：WO2007103209A2

    公开(公告)日：2007-09-13

    申请号：PCT/US2007/005436

    申请日：2007-03-01

    Applicant: FMC BIOPOLYMER AS ,  FMC CORPORATION ,  GASEROD, Olav ,  ANDERSEN, Therese ,  MELVIK, Jan, Egil ,  DORNISH, Michael ,  RILEY, Peter, J.

    Inventor： GASEROD, Olav ,  ANDERSEN, Therese ,  MELVIK, Jan, Egil ,  DORNISH, Michael ,  RILEY, Peter, J.

    IPC: A61L27/20 ,  A61L27/38 ,  A61L27/48

    CPC classification number: A61L27/56 ,  A61K9/122 ,  A61K47/36 ,  A61L27/20 ,  A61L27/38 ,  A61L27/48

    Abstract: The invention relates to composites comprising a polysaccharide gelled within pores of a foam, methods of preparation, and uses thereof, for example, in biomedical applications such as cell culture media and implants, controlled release delivery systems, food applications, industrial applications, and personal care applications such as cosmetic and oral hygiene. The composites of the present invention are simple to formulate using few steps and are useful for entrapping heat-sensitive components, such as cells, drugs, flavors or fragrances within the polysaccharide gel. In addition, the invention provides for a composite able to gently immobilize fragile components, such as living cells, without exposing such components to shear forces.

    Abstract translation: 本发明涉及包含在泡沫的孔内凝胶化的多糖的复合材料，制备方法及其用途，例如在生物医学应用中，例如细胞培养基和植入物，控制释放递送系统，食品应用，工业应用和个人 护理应用如化妆品和口腔卫生。 本发明的复合材料使用几个步骤简单的配制，并且可用于在多糖凝胶内捕获热敏组分如细胞，药物，香料或香料。 此外，本发明提供了一种复合材料，其能够轻柔地固定易碎组分如活细胞，而不会使这些组分暴露于剪切力。

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