公开(公告)号：WO2003064403A1

公开(公告)日：2003-08-07

申请号：PCT/US2003/002766

申请日：2003-01-30

Applicant: GALILEO LABORATORIES, INC.

Inventor： WANG, Bing ,  ZHANG, Wei ,  SONG, Jiangao ,  DEL BALZO, Ughetta ,  BROWN, Lesley ,  WALKINSHAW, Gail

IPC: C07D305/12

CPC classification number: C07D417/14 ,  C07D307/64 ,  C07D307/68 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/12 ,  C07D421/14 ,  C07D495/04

Abstract: Furanone derivatives and the pharmaceutically acceptable salts thereof have cytoprotective activity and protective activity for neuroinflammation, and neurodegenerative disorders; they are useful in the treatment of stroke, cerebral ischemia, myocardial infarction, myocardial ischemia, chronic heart failure, inflammation and other oxidative stress-related conditions, as well as Alzheimer's disease and senile dementia; they are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.

Abstract translation: 呋喃酮衍生物及其药学上可接受的盐具有细胞保护活性和神经炎症的保护活性，以及​​它们可用于治疗中风，脑缺血，心肌梗死，心肌缺血，慢性心力衰竭，炎症和其它氧化应激相关病症的神经变性疾病 ，以及阿尔茨海默病和老年痴呆，它们也可用于制备用于治疗这些病症的药物制剂。

公开(公告)号：WO2003009807A2

公开(公告)日：2003-02-06

申请号：PCT/US2002/023509

申请日：2002-07-23

Applicant: GALILEO LABORATORIES, INC.

Inventor： WANG, Bing ,  ZHANG, Yong-Kang ,  CHEN, Jian ,  ZHANG, Wei ,  SONG, Jiangao ,  DEL BALZO, Ughetta ,  BROWN, Lesley ,  MILLER, Guy

IPC: A61K

CPC classification number: C07D213/30 ,  C07C43/23 ,  C07C45/30 ,  C07C45/71 ,  C07C49/737 ,  C07C69/94 ,  C07C205/17 ,  C07C205/20 ,  C07C205/22 ,  C07C205/35 ,  C07C205/57 ,  C07C235/42 ,  C07C255/36 ,  C07C311/29 ,  C07C2603/24 ,  C07D213/53 ,  C07D231/26 ,  C07D277/20 ,  C07D277/24 ,  C07D295/26 ,  C07D311/72 ,  C07F9/4021 ,  C07C47/575

Abstract: Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituded phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infraction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.

Abstract translation: 细胞保护性化合物，其中许多是以具有某些缀合键的取代苯酚为特征的酚类衍生物，可用于治疗某些缺血性或炎性疾病，包括但不限于中风，心肌梗塞，充血性心力衰竭和特征为 炎症或氧化损伤。 它们也可用于制造用于治疗这些病症的药物和化妆品制剂。

公开(公告)号：WO2003009807A3

公开(公告)日：2003-02-06

申请号：PCT/US2002/023509

申请日：2002-07-23

Applicant: GALILEO LABORATORIES, INC.

Inventor： WANG, Bing ,  ZHANG, Yong-Kang ,  CHEN, Jian ,  ZHANG, Wei ,  SONG, Jiangao ,  DEL BALZO, Ughetta ,  BROWN, Lesley ,  MILLER, Guy

IPC: A61K31/185

Abstract: Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituded phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infraction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.