公开(公告)号：WO2003064403A1

公开(公告)日：2003-08-07

申请号：PCT/US2003/002766

申请日：2003-01-30

Applicant: GALILEO LABORATORIES, INC.

Inventor： WANG, Bing ,  ZHANG, Wei ,  SONG, Jiangao ,  DEL BALZO, Ughetta ,  BROWN, Lesley ,  WALKINSHAW, Gail

IPC: C07D305/12

CPC classification number: C07D417/14 ,  C07D307/64 ,  C07D307/68 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/12 ,  C07D421/14 ,  C07D495/04

Abstract: Furanone derivatives and the pharmaceutically acceptable salts thereof have cytoprotective activity and protective activity for neuroinflammation, and neurodegenerative disorders; they are useful in the treatment of stroke, cerebral ischemia, myocardial infarction, myocardial ischemia, chronic heart failure, inflammation and other oxidative stress-related conditions, as well as Alzheimer's disease and senile dementia; they are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.

Abstract translation: 呋喃酮衍生物及其药学上可接受的盐具有细胞保护活性和神经炎症的保护活性，以及​​它们可用于治疗中风，脑缺血，心肌梗死，心肌缺血，慢性心力衰竭，炎症和其它氧化应激相关病症的神经变性疾病 ，以及阿尔茨海默病和老年痴呆，它们也可用于制备用于治疗这些病症的药物制剂。

公开(公告)号：WO2003066618A1

公开(公告)日：2003-08-14

申请号：PCT/US2003/003709

申请日：2003-02-06

Applicant: GALILEO LABORATORIES, INC.

Inventor： WANG, Bing ,  CHEN,Jian

IPC: C07D307/78

CPC classification number: C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D307/84 ,  C07D413/04 ,  C07D493/04

Abstract: Cytoprotective compounds, many of which are benzofuran derivatives are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.

Abstract translation: 其中许多是苯并呋喃衍生物的细胞保护化合物可用于治疗某些缺血性或炎症性疾病，包括但不限于中风，心肌梗死，充血性心力衰竭和以炎症或氧化损伤为特征的皮肤病症。 它们也可用于制备用于治疗这些病症的药物和化妆品制剂。

公开(公告)号：WO2003009807A2

公开(公告)日：2003-02-06

申请号：PCT/US2002/023509

申请日：2002-07-23

Applicant: GALILEO LABORATORIES, INC.

Inventor： WANG, Bing ,  ZHANG, Yong-Kang ,  CHEN, Jian ,  ZHANG, Wei ,  SONG, Jiangao ,  DEL BALZO, Ughetta ,  BROWN, Lesley ,  MILLER, Guy

IPC: A61K

CPC classification number: C07D213/30 ,  C07C43/23 ,  C07C45/30 ,  C07C45/71 ,  C07C49/737 ,  C07C69/94 ,  C07C205/17 ,  C07C205/20 ,  C07C205/22 ,  C07C205/35 ,  C07C205/57 ,  C07C235/42 ,  C07C255/36 ,  C07C311/29 ,  C07C2603/24 ,  C07D213/53 ,  C07D231/26 ,  C07D277/20 ,  C07D277/24 ,  C07D295/26 ,  C07D311/72 ,  C07F9/4021 ,  C07C47/575

Abstract: Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituded phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infraction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.

Abstract translation: 细胞保护性化合物，其中许多是以具有某些缀合键的取代苯酚为特征的酚类衍生物，可用于治疗某些缺血性或炎性疾病，包括但不限于中风，心肌梗塞，充血性心力衰竭和特征为 炎症或氧化损伤。 它们也可用于制造用于治疗这些病症的药物和化妆品制剂。

公开(公告)号：WO2003009807A3

公开(公告)日：2003-02-06

申请号：PCT/US2002/023509

申请日：2002-07-23

Applicant: GALILEO LABORATORIES, INC.

Inventor： WANG, Bing ,  ZHANG, Yong-Kang ,  CHEN, Jian ,  ZHANG, Wei ,  SONG, Jiangao ,  DEL BALZO, Ughetta ,  BROWN, Lesley ,  MILLER, Guy

IPC: A61K31/185

Abstract: Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituded phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infraction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.

公开(公告)号：WO2002047680A3

公开(公告)日：2002-06-20

申请号：PCT/US2001/050984

申请日：2001-12-14

Applicant: GALILEO LABORATORIES, INC. ,  MILLER, Guy, Michael ,  BROWN, Lesley, A. ,  DEL BALZO, Ughetta ,  FLAIM, Stephen ,  BODDUPALLI, Sekhar ,  WANG, Bing

Inventor： MILLER, Guy, Michael ,  BROWN, Lesley, A. ,  DEL BALZO, Ughetta ,  FLAIM, Stephen ,  BODDUPALLI, Sekhar ,  WANG, Bing

IPC: A61K31/352

Abstract: The present invention provides compositions and methods for the treatment of tissue ischemia, and in particular, cerebral ischemia. In particular, the present invention provides gamma-, beta-, or delta-tocopherol enriched tocopherol compositions and gamma-, beta, or delta-tocopherol metabolite enriched compositions and/or flavonoid enriched and/or a flavonoid derivative enriched compositions and methods for their use in preventing or treating a tissue ischemic condition or a cerebral ischemic condition. The present invention also provides pharmaceutical compositions comprising gamma-, beta-, or delta-tocopherol enriched tocopherol composition, a gamma-, beta-, or delta-tocopherol metabolite enriched compositions or flavonoid enriched compositions or flavonoid derivative enriched compositions.

公开(公告)号：WO2002090314A1

公开(公告)日：2002-11-14

申请号：PCT/US2002/014057

申请日：2002-05-03

Applicant: GALILEO LABORATORIES, INC. ,  WANG, Bing ,  MILLER, Guy ,  FLAIM, Stephen, F. ,  DEL BALZO, Ughetta ,  ZHANG, Wei ,  JANAGANI, Satyanarayana ,  SONG, Jingao

Inventor： WANG, Bing ,  MILLER, Guy ,  FLAIM, Stephen, F. ,  DEL BALZO, Ughetta ,  ZHANG, Wei ,  JANAGANI, Satyanarayana ,  SONG, Jingao

IPC: C07C69/66

CPC classification number: C07D213/30 ,  A61K31/12 ,  A61K31/16 ,  A61K31/215 ,  A61K31/223 ,  A61K38/00 ,  C07C249/12 ,  C07C319/20 ,  C07C323/60 ,  C07D207/16 ,  C07D207/22 ,  C07D207/24 ,  C07D211/62 ,  C07D211/74 ,  C07D211/78 ,  C07D217/04 ,  C07D233/42 ,  C07D233/64 ,  C07D233/84 ,  C07D235/28 ,  C07D239/78 ,  C07D249/14 ,  C07D271/113 ,  C07D277/16 ,  C07D277/74 ,  C07D279/12 ,  C07D285/125 ,  C07D285/135 ,  C07D295/13 ,  C07D295/15 ,  C07D295/185 ,  C07D339/08 ,  C07D345/00 ,  C07D405/12 ,  C07D473/38 ,  C07K5/0215 ,  C07K5/0819 ,  C07C323/57 ,  C07C251/60

Abstract: Certain known and novel pyruvate derivatives are particularly active in restoring or preserving metabolic integrity in oxidatively competent cells that have been subjected to oxygen deprivation. These pyruvate-derived compounds include, but are not limited to oximes, amides, pyruvate analogues, modified pyruvate analogues, esters of pyruvate (e.g., polyol-pyruvate esters, pyruvate thioesters, glycerol-pyruvate esters and dihydroxyacetone-pyruvate esters). Such pyruvate derivatives (including single tautomers, single stereoisomers and mixtures of tautomers and/or stereoisomers, and the pharmaceutically acceptable salts thereof) are useful in the manufacture of pharmaceutical compositions for treating a number of conditions characterized by oxidative stress.

Abstract translation: 某些已知和新颖的丙酮酸衍生物在恢复或保持已经遭受氧剥夺的氧化感受态细胞中的代谢完整性方面特别有活性。 这些丙酮酸衍生化合物包括但不限于肟，酰胺，丙酮酸盐类似物，改性丙酮酸盐类似物，丙酮酸酯（例如多元醇 - 丙酮酸酯，丙酮酸硫酯，甘油 - 丙酮酸酯和二羟基丙酮 - 丙酮酸酯）。 这样的丙酮酸衍生物（包括单互变异构体，单立体异构体和互变异构体和/或立体异构体的混合物及其药学上可接受的盐）可用于制备用于治疗以氧化应激为特征的许多病症的药物组合物。