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    SYSTEM AND METHOD FOR FILTRATION AND/OR DILUTION OF FLUIDS
    2.
    发明申请
    SYSTEM AND METHOD FOR FILTRATION AND/OR DILUTION OF FLUIDS 审中-公开

    公开(公告)号：WO2018229174A2

    公开(公告)日：2018-12-20

    申请号：PCT/EP2018/065759

    申请日：2018-06-14

    Applicant: GAMBRO LUNDIA AB

    Inventor： JANSSON, Olof ,  ERICSON, Bjoern ,  HALL, Henrik

    IPC: B01D61/24 ,  B01D61/28 ,  B01D61/32 ,  B01D63/02 ,  A61M1/34 ,  B01D63/04 ,  A61M1/16 ,  B01D61/58

    Abstract: The present invention relates to systems and methods for filtration and/or dilution of fluids, in particular for the dialysis of blood. The systems comprise a filter device (10) having a fluid chamber (18) and comprising a first lid (20) having arranged thereon a first fluid port (22). The filter device (10) further comprises a second lid (30) having arranged thereon at least a second fluid port (32). The filter device (10) further comprises a plurality of hollow fibers (40) arranged within the housing (12),wherein each of the plurality of hollow fibers (40) comprises a semi-permeable membrane and defines a fluid channel extending longitudinally through an interior of the respective hollow fiber (40). Also, the filter device (10) comprises a fourth fluid port (50) and a fifth fluid port (52) both provided at the fluid chamber (18).

    SYSTEMS AND METHODS FOR PERITONEAL DIALYSIS HAVING POINT OF USE DIALYSIS FLUID PREPARATION USING WATER ACCUMULATOR AND DISPOSABLE SET
    4.
    发明申请
    SYSTEMS AND METHODS FOR PERITONEAL DIALYSIS HAVING POINT OF USE DIALYSIS FLUID PREPARATION USING WATER ACCUMULATOR AND DISPOSABLE SET 审中-公开
    用于腹膜透析的系统和方法，具有使用蓄水器和一次性使用装置的使用透析流体制剂

    公开(公告)号：WO2017193069A1

    公开(公告)日：2017-11-09

    申请号：PCT/US2017/031400

    申请日：2017-05-05

    Applicant: GAMBRO LUNDIA AB ,  SZPARA, Edward

    Inventor： SZPARA, Edward ,  EKDAHL, Olof ,  JANSSON, Olof

    IPC: A61M1/28

    Abstract: A peritoneal dialysis system includes a water purifier, a cycler, and a disposable set operable with the cycler. The disposable set includes a pumping cassette including a water inlet port, a heater/mixing container in fluid communication with the pumping cassette, a water accumulator, a first water line segment, and a second water line segment. The first water line segment is in fluid communication with the water inlet port and the water accumulator. Additionally, the second water line segment is in fluid communication with the water accumulator and the water purifier.

    Abstract translation: 腹膜透析系统包括净水器，循环仪和可与循环仪一起操作的一次性使用套件。 该一次性装置包括泵送盒，该泵送盒包括进水口，与泵送盒流体连通的加热器/混合容器，蓄水器，第一水线段和第二水线段。 第一水管线段与进水口和蓄水器流体连通。 另外，第二水管线段与蓄水器和净水器流体连通。

    INDIVIDUAL PUMP CALIBRATION FOR ULTRAFILTRATION CONTROL IN A DIALYSIS APPARATUS
    5.
    发明申请
    INDIVIDUAL PUMP CALIBRATION FOR ULTRAFILTRATION CONTROL IN A DIALYSIS APPARATUS 审中-公开
    用于DIALYSIS设备中超声波控制的个体泵校准

    公开(公告)号：WO2015007595A1

    公开(公告)日：2015-01-22

    申请号：PCT/EP2014/064743

    申请日：2014-07-09

    Applicant: GAMBRO LUNDIA AB

    Inventor： JANSSON, Olof

    IPC: A61M1/16 ,  A61M1/34 ,  F04B43/00

    CPC classification number: A61M1/1615 ,  A61M1/16 ,  A61M1/165 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3413 ,  A61M2205/12 ,  A61M2205/3334 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3389 ,  A61M2205/3396 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2205/70 ,  A61M2205/702 ,  F04B49/065 ,  F04B51/00

    Abstract: A control unit (30) is arranged to control a dialysis fluid distribution system (12) comprising first and second volumetric pumps (PI, P2) arranged upstream and downstream of a dialyzer (13). The control unit (30) is operable in a calibration mode, to establish a bypass flow path that bypasses the dialyzer (13) and extends from the first pump (P1) to the second pump (P2) in fluid communication with a calibration chamber (26) and to operate the pumps (P1, P2) at different combinations of speeds that cause first and second changes in fluid level in the chamber (26). The first and second changes correspond to first and second known volumes in the chamber (26). The control unit (30) measures, by a level detector (28) in the chamber (26), first and second time periods for the first and second changes, and computes the stroke volumes of the pumps (P1, P2) as a function of the speeds of the pumps (PI, P2), the first and second time periods, and the first and second known volumes. By computing the stroke volumes, the control unit (30) is operable to achieve an accurate ultrafiltration (UF) rate in the dialyzer (13) by controlling the relative speeds of the pumps (P1, P2).

    Abstract translation: 控制单元（30）被布置成控制透析液体分配系统（12），其包括布置在透析器（13）的上游和下游的第一和第二体积泵（PI，P2）。 控制单元（30）可在校准模式下操作，以建立绕过透析器（13）并从第一泵（P1）延伸到第二泵（P2）的旁路流动路径，其与校准室流体连通 并且以不同的速度组合来操作泵（P1，P2），这些组合导致腔室（26）中的液位的第一和第二变化。 第一和第二改变对应于腔室（26）中的第一和第二已知体积。 控制单元（30）通过室（26）中的液位检测器（28）测量用于第一和第二变化的第一和第二时间段，并且将泵（P1，P2）的行程体积计算为函数 的泵（PI，P2）的速度，第一和第二时间段以及第一和第二已知体积。 通过计算行程体积，控制单元（30）可操作以通过控制泵（P1，P2）的相对速度来实现透析器（13）中的精确超滤（UF）速率。

    DISPOSABLES FOR BLOOD TREATMENT, AND METHODS OF OPERATING THE SAME
    6.
    发明申请
    DISPOSABLES FOR BLOOD TREATMENT, AND METHODS OF OPERATING THE SAME 审中-公开
    用于血液治疗的药物及其操作方法

    公开(公告)号：WO2012175435A1

    公开(公告)日：2012-12-27

    申请号：PCT/EP2012/061551

    申请日：2012-06-18

    Applicant: GAMBRO LUNDIA AB ,  JANSSON, Olof ,  HOLMER, Mattias ,  NILSSON, Eddie ,  JÖNSSON, Lennart

    Inventor： JANSSON, Olof ,  HOLMER, Mattias ,  NILSSON, Eddie ,  JÖNSSON, Lennart

    IPC: A61M1/30 ,  A61M1/36

    CPC classification number: A61M1/367 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/306 ,  A61M1/3621 ,  A61M2205/125 ,  A61M2205/128 ,  Y10T137/0318 ,  Y10T137/85986 ,  Y10T137/86035

    Abstract: A disposable for use in blood treatment comprises a blood treatment unit (8) and a pump arrangement (11) operable to pump blood through the blood treatment unit (8). The pump arrangement (11) comprises two membrane pumps (6, 7) connected in parallel on one side of the blood treatment unit (8). The disposable is operable in a single-needle mode, in which the pump arrangement (11) is operable to generate a pulsatile flow of blood through the blood treatment unit (8), and in a double-needle mode, in which the pump arrangement (11) is operable to generate an essentially continuous flow of blood through the blood treatment unit (8). The pump arrangement (11) is configured for connection to a supply system (1) of treatment fluid for the blood treatment unit (8) such that alternating flows of treatment fluid generated by the supply system (1) and supplied to the first and second membrane pumps (6, 7) causes the pump arrangement (11) to generate the desired flows of blood in the single-needle and double- needle modes. The treatment fluid may be used as motive fluid for displacing the blood in the membrane pumps (6, 7) and/or as control fluid for controlling opening and/or closing of upstream and downstream commutation valves (34, 35) in the membrane pumps (6, 7).

    Abstract translation: 用于血液处理的一次性用品包括血液处理单元（8）和可操作以将血液泵送通过血液处理单元（8）的泵装置（11）。 泵装置（11）包括在血液处理单元（8）的一侧上并联连接的两个膜泵（6,7）。 一次性可以单针模式操作，其中泵装置（11）可操作以通过血液处理单元（8）产生脉动血液流，并且在双针模式中，泵装置 （11）可操作以通过血液处理单元（8）产生基本上连续的血液流。 泵装置（11）构造成用于连接到用于血液处理单元（8）的处理流体的供应系统（1），使得由供应系统（1）产生并供应到第一和第二 膜泵（6,7）使泵装置（11）以单针和双针模式产生所需的血液流。 处理流体可以用作移动膜泵（6,7）中的血液的运动流体和/或用作控制膜泵中上游和下游换向阀（34,35）的打开和/或关闭的控制流体 （6,7）。

    PREPARATION OF MEDICAL SOLUTIONS FROM POWDERY MATERIAL
    7.
    发明申请
    PREPARATION OF MEDICAL SOLUTIONS FROM POWDERY MATERIAL 审中-公开
    从粉末材料制备医疗解决方案

    公开(公告)号：WO2011161064A1

    公开(公告)日：2011-12-29

    申请号：PCT/EP2011/060255

    申请日：2011-06-20

    Applicant: GAMBRO LUNDIA AB ,  JANSSON, Olof ,  JÖNSSON, Lennart ,  LINDEN, Torbjörn ,  STERNBY, Jan ,  TRYGGVASON, Ragnar ,  WIESLANDER, Anders

    Inventor： JANSSON, Olof ,  JÖNSSON, Lennart ,  LINDEN, Torbjörn ,  STERNBY, Jan ,  TRYGGVASON, Ragnar ,  WIESLANDER, Anders

    IPC: A61J1/20 ,  A61M1/16

    CPC classification number: A61J1/20 ,  A61J1/2093 ,  A61M1/1656 ,  A61M1/1666 ,  A61M1/1668 ,  A61M1/167 ,  A61M1/287 ,  B65D31/14 ,  B65D81/18 ,  B65D81/20 ,  B65D81/2007 ,  B65D81/2023 ,  B65D81/2046

    Abstract: A package has a transport/storage state for storing powdery material which is to be mixed with a solvent to form a medical solution, e.g. for use in dialysis treatment. The package comprises a compartment (6) which is at least partially defined by two opposing wall portions, and a connector (10). In the transport/storage state, the compartment contains the powdery material in the form of at least two distinct sets (2A-2D) of powdery material of different compositions, where the opposing wall portions are brought into engagement with the powdery material so as to immobilize the sets of powdery material (2A-2D). When used for preparation of the medical solution, a fluid is selectively admitted into the package via the connector (10) so as to expand the compartment (6) and enable mixing of the sets (2A-2D) of powdery material with the solvent in the compartment (6).

    Abstract translation: 包装具有用于储存待与溶剂混合以形成医用溶液的粉末状材料的运输/储存状态， 用于透析治疗。 该包装件包括至少部分地由两个相对的壁部分限定的隔室（6）和连接器（10）。 在运输/储存状态下，隔室含有至少两种不同组成的粉末材料组（2A-2D）形式的粉状材料，其中相对的壁部分与粉末材料接合，以便 固定一组粉状材料（2A-2D）。 当用于制备医用溶液时，通过连接器（10）将流体选择性地进入包装中，以便使隔室（6）膨胀，并使粉末材料组（2A-2D）与溶剂的组合 隔室（6）。

    RENAL FAILURE THERAPY SYSTEMS HAVING REDUCED TIME BETWEEN TREATMENTS
    9.
    发明申请
    RENAL FAILURE THERAPY SYSTEMS HAVING REDUCED TIME BETWEEN TREATMENTS 审中-公开

    公开(公告)号：WO2022022893A1

    公开(公告)日：2022-02-03

    申请号：PCT/EP2021/067053

    申请日：2021-06-23

    Applicant: GAMBRO LUNDIA AB

    Inventor： BORGQVIST, Per-Olof ,  JANSSON, Olof

    IPC: A61M1/16

    Abstract: A renal failure therapy system (10) includes: a fresh dialysis fluid (possibly flexible) tube (72) having a connector (72a) for connecting to a dialyzer (102); a spent dialysis fluid (possibly flexible) tube (74) having a connector (74a) for connecting to the dialyzer (102); a dialysis fluid circuit (30) including a fresh dialysis fluid line (70), a spent dialysis fluid line (56), at least one of (i) a first disinfection device (90a) positioned between the fresh dialysis fluid line (70) and the fresh dialysis fluid tube (72), or (ii) a second disinfection device (90c) positioned between the spent dialysis fluid line (70) and the spent dialysis fluid tube (74), and recirculation circuitry extending to (i) a first machine connector (28a) for mating with the connector (72a) of the fresh dialysis fluid tube (72) during local disinfection and (ii) a second machine connector (28c) for mating with the connector (74a) of the spent dialysis fluid tube (74) during local disinfection; and a control unit (20) configured to cause the first and second disinfection devices (90a, 90b) to be energized during the local disinfection.

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    10.
    发明申请
    "METHOD AND SYSTEM FOR PROVIDING PERITONEAL DIALYSIS FLUIDS WITH VARYING SODIUM CONCENTRATIONS" 审中-公开

    公开(公告)号：WO2019086318A1

    公开(公告)日：2019-05-09

    申请号：PCT/EP2018/079245

    申请日：2018-10-25

    Applicant: GAMBRO LUNDIA AB

    Inventor： JANSSON, Olof ,  WIESLANDER, Anders

    IPC: A61K47/02 ,  A61M1/28 ,  A61K9/08 ,  A61K31/00

    Abstract: Methods are provided for preparing a ready-to-use peritoneal dialysis fluid for peritoneal dialysis of a patient. The methods comprise mixing, immediately before administration to the patient, appropriate amounts of at least a first concentrate and a second concentrate with an appropriate amount of water to form a ready-to-use dialysis fluid. The first concentrate comprises glucose and has a pH of between 1.5 and 4; and the second concentrate comprises a physiologically acceptable buffer and sodium ions, and has a pH of between 5.0 and 9.0. The ready-to-use dialysis fluid has a sodium ion concentration of about 110 mM to about 145 mM and an osmolality of about 0.20 to about 0.50 Osm/kg.

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