公开(公告)号：WO2020120004A1

公开(公告)日：2020-06-18

申请号：PCT/EP2019/079721

申请日：2019-10-30

Applicant: GAMBRO LUNDIA AB

Inventor： HOBRO, Sture ,  ALSON, Jonas ,  NILSSON, Anders ,  FORSAL, Innas

IPC: A61M1/36 ,  A61M1/34

Abstract: A monitoring device operates to monitor regional citrate anticoagulation (RCA) in a blood treatment system which is configured to administrate citrate to an extracorporeal blood circuit (10) upstream of a dialyzer (11) during a treatment session. At consecutive time steps during the treatment session, the monitoring device obtains a current measurement value of systemic ionized calcium ( iCa SYS ) or systemic total calcium ( Ca SYS ), operates a predefined algorithm on the current measurement value to generate a current computation value that represents ionized calcium ( iCa 2 , iCa 3 ) in blood at a selected location ( loc2, loc3 ) downstream or upstream of the dialyzer (11) in the extracorporeal blood circuit (10), and presents and/or evaluates the current computation value for assessment of the regional citrate anticoagulation. The need for conventional blood sampling and blood analysis upstream and/or downstream of the dialyzer, e.g. during CRRT, is thereby reduced significantly.

公开(公告)号：WO2018095694A1

公开(公告)日：2018-05-31

申请号：PCT/EP2017/077566

申请日：2017-10-27

Applicant: GAMBRO LUNDIA AB

Inventor： WALLENBORG, Anders ,  NILSSON, Anders ,  SOLEM, Kristian ,  HERTZ, Thomas ,  ROVATTI, Paolo ,  LODI, Carlo, Alberto ,  SURACE, Alessandro ,  STERNBY, Jan

IPC: A61M1/16 ,  A61M1/34

Abstract: An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid, and a sensor (11) for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit (12) configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and/or the substitution fluid, measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value of the spent dialysis fluid and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating the dialysis fluid up to the calculating of the initial plasma conductivity being performed maintaining the dialysis fluid conductivity substantially constant.

公开(公告)号：WO2018095691A1

公开(公告)日：2018-05-31

申请号：PCT/EP2017/077530

申请日：2017-10-26

Applicant: GAMBRO LUNDIA AB

Inventor： NILSSON, Anders

IPC: A61M1/16 ,  A61M1/34

Abstract: An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32); a control unit (12) is configured for calculating a sodium concentration value for the blood; the estimation of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the isoconductive sodium concentrate and of an offset contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate and phosphate.

公开(公告)号：WO2009127624A3

公开(公告)日：2009-10-22

申请号：PCT/EP2009/054406

申请日：2009-04-14

Applicant: GAMBRO LUNDIA AB ,  JÖNSSON, Lennart ,  JANSSON, Olof ,  HOLMER, Mattias ,  STERNBY, Jan ,  NILSSON, Anders ,  HANSSON, Per

Inventor： JÖNSSON, Lennart ,  JANSSON, Olof ,  HOLMER, Mattias ,  STERNBY, Jan ,  NILSSON, Anders ,  HANSSON, Per

IPC: A61M1/10 ,  A61M1/16 ,  A61M1/30 ,  A61M1/34

Abstract: A proposed blood treatment apparatus includes : a blood treatment unit (8), a pair of fluid pumps (14, 15) and a pair of blood pumps (1a, 1b). The blood treatment unit (8) is configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid. The fluid pumps (14, 15) are configured to pass blood treatment fluid through the blood treatment unit (8). The blood pumps (1a, 1b) are configured to extract untreated blood from a blood source (S), pass extracted blood through the blood treatment unit (8) and deliver treated blood to a target vessel (T). Additionally, the fluid pumps (14, 15) are configured to control the operation of the blood pumps (1a, 1b) via the blood treatment fluid. Moreover, a flow control means (16a) is configured to control a trans- membrane flow between the blood side (8B) and the a fluid side (8F) of the blood treatment unit (8). Hence, for instance ultrafiltration can be adjusted to a desired level in a very straightforward manner.

公开(公告)号：WO2021245040A1

公开(公告)日：2021-12-09

申请号：PCT/EP2021/064592

申请日：2021-06-01

Applicant: GAMBRO LUNDIA AB

Inventor： HOBRO, Sture ,  FORSAL, Innas ,  HANCOCK, Viktoria ,  NILSSON, Anders

IPC: A61M1/16 ,  A61M1/1603 ,  A61M1/1654 ,  A61M2230/20

Abstract: The present application relates to an extracorporeal blood treatment system (50) for treating a subject, the system comprising: an extracorporeal blood circuit (52); a dialysate fluid circuit (54); said extracorporeal blood circuit and dialysate fluid circuit being divided by a membrane (56) of a filtration unit (58); at least one blood pump (60) for controlling the flow of blood through the blood circuit; at least one dialysate fluid pump (62) for controlling the flow of dialysate fluid through the dialysate fluid circuit (54); a system computing unit (64) operatively connected to the blood pump and the dialysate fluid pump, said system computing unit having at least one input means; wherein the system computing unit is adapted for receiving a desired blood concentration GLNb of glutamine, for receiving a desired blood concentration GLUCOSEb of glucose, and for receiving a desired blood concentration of a ketone body KETONEb; the system computing unit being adapted for controlling said blood pump and said dialysate fluid pump so as the actual concentration value GLNa of glutamine is driven towards GLNb and the actual concentration value GLUCOSEa of glucose is driven towards Db. and the actual concentration value of ketone bodies is driven towards KETONEa. The application also relates to a therapy set for use in the extracorporeal blood treatment system, a method for treating cancer using the system, a controller for controlling the method as well as a dialysis liquid suitable for the method.

公开(公告)号：WO2013131906A1

公开(公告)日：2013-09-12

申请号：PCT/EP2013/054386

申请日：2013-03-05

Applicant: GAMBRO LUNDIA AB

Inventor： NILSSON, Anders ,  STERNBY, Jan ,  WIESLANDER, Anders

IPC: A61K31/194 ,  A61K33/06 ,  A61K33/14 ,  A61P7/08

CPC classification number: A61K9/08 ,  A61K31/194 ,  A61K33/06 ,  A61K33/14 ,  A61M1/1654 ,  A61K2300/00

Abstract: The present invention concerns dialysis compositions comprising 0.5 to 3 mM citrate, 1 to 5 mM total calcium, and 0 to 1.5 mM total magnesium.

Abstract translation: 本发明涉及包含0.5至3mM柠檬酸盐，1至5mM总钙和0至1.5mM总镁的透析组合物。

公开(公告)号：WO2016188951A1

公开(公告)日：2016-12-01

申请号：PCT/EP2016/061569

申请日：2016-05-23

Applicant: GAMBRO LUNDIA AB

Inventor： ROVATTI, Paolo ,  LODI, Carlo Alberto ,  SURACE, Alessandro ,  WALLENBORG, Anders ,  NILSSON, Anders ,  SOLEM, Kristian ,  STERNBY, Jan ,  HERTZ, Thomas

IPC: A61M1/16 ,  A61M1/36

CPC classification number: A61M1/1605 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/1656 ,  A61M1/1666 ,  A61M1/3406 ,  A61M1/3609 ,  A61M2205/128 ,  A61M2230/005 ,  A61M2230/20 ,  A61M2230/65

Abstract: An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line (8) at a set point; the setting of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the blood plasma conductivity and of an adjustment contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate, and phosphate.

Abstract translation: 提供一种体外血液处理装置，包括与血液回路（17）连接的过滤单元（2）和透析液回路（32），制备和调节透析液的组成的准备装置（9） 控制单元（12）被配置为在透析供给管线（8）中将透析液的钠浓度值设定在设定点; 钠浓度的设定包括基于血浆电导率和基于透析中的至少一种物质的浓度的调整贡献项计算钠浓度值作为主要贡献项的代数和的子步骤 在组中选择的液体包括碳酸氢盐，钾，乙酸盐，乳酸盐，柠檬酸盐，镁，钙，硫酸盐和磷酸盐。

公开(公告)号：WO2012035040A1

公开(公告)日：2012-03-22

申请号：PCT/EP2011/065894

申请日：2011-09-14

Applicant: GAMBRO LUNDIA AB ,  HANSSON, Per ,  HERTZ, Thomas ,  HOLMER, Mattias ,  JÖNSSON, Lennart ,  NILSSON, Anders ,  WALLENBORG, Anders ,  ANDERSSON, Johan

Inventor： HANSSON, Per ,  HERTZ, Thomas ,  HOLMER, Mattias ,  JÖNSSON, Lennart ,  NILSSON, Anders ,  WALLENBORG, Anders ,  ANDERSSON, Johan

IPC: A61M1/14 ,  A61M1/36

CPC classification number: A61M1/367 ,  A61M1/14 ,  A61M1/1601 ,  A61M1/3621 ,  A61M2205/3317 ,  A61M2205/3334 ,  A61M2205/50 ,  Y10T29/49002

Abstract: A blood treatment apparatus (2) comprising: a blood treatment unit (10); a blood line (20) configured to extract blood from a blood source (21), pass the blood through the blood treatment unit (10) and deliver treated blood to a target vessel (22); and a fluid line (30) configured pass treatment fluid through the blood treatment unit (10) and deliver used treatment fluid to a fluid sink (32). A flow divider (40) is arranged in the fluid line (30) separates treatment fluid into to a first fluid section (51) and a second fluid section (53), thereby electrically isolating the fluid sections (51, 53) such that electrical current flowing in the fluid line (30) between the fluid sections (51, 53) is limited. Related manufacturing and verification methods are also described.

Abstract translation: 一种血液处理装置（2），包括：血液处理单元（10）; 构成为从血液源（21）取出血液的血液线（20），使血液通过血液处理单元（10），将处理后的血液输送到目标血管（22）。 并且流体管线（30）构造成通过处理液通过血液处理单元（10）并将使用的处理流体输送到流体槽（32）。 在流体管线（30）中布置有分流器（40），其将处理流体分离成第一流体部分（51）和第二流体部分（53），从而将流体部分（51,53）电隔离，使得电气 在流体管线（30）内流动的流体部分（51,53）之间的电流受到限制。 还描述了相关的制造和验证方法。

公开(公告)号：WO2018114276A1

公开(公告)日：2018-06-28

申请号：PCT/EP2017/081064

申请日：2017-11-30

Applicant: GAMBRO LUNDIA AB

Inventor： NILSSON, Anders

IPC: A61M1/16 ,  A61M1/34

Abstract: An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for receiving a conductivity or sodium concentration set point for the dialysis fluid and for calculating a mass transport of a substance at an instant t of a treatment session based on said set value of the parameter for the dialysis fluid in the dialysis supply line (8).

公开(公告)号：WO2016188952A1

公开(公告)日：2016-12-01

申请号：PCT/EP2016/061570

申请日：2016-05-23

Applicant: GAMBRO LUNDIA AB

Inventor： NILSSON, Anders

IPC: A61M1/16 ,  A61M1/36

CPC classification number: A61M1/1607 ,  A61M1/267 ,  A61M1/301 ,  A61M1/3406 ,  A61M1/3413 ,  A61M2205/3317 ,  A61M2205/3334 ,  A61M2205/3337 ,  A61M2205/502 ,  A61M2230/20 ,  G01N27/04 ,  G01N33/49 ,  G01R19/0023 ,  G01R19/22 ,  G01R19/225

Abstract: An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32); a control unit (12) is configured for calculating a sodium concentration value for the blood; the estimation of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the isoconductive sodium concentrate and of an offset contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate and phosphate.

Abstract translation: 提供一种体外血液处理装置，其包括连接到血液回路（17）和透析液回路（32）的过滤单元（2）。 控制单元（12）被配置为计算血液的钠浓度值; 钠浓度的估计包括计算钠浓度值作为基于等离子体浓缩钠的主要贡献项的代数和基于透析中至少一种物质的浓度的补偿贡献项的子步骤 在组中选择的液体包括碳酸氢盐，钾，乙酸盐，乳酸盐，柠檬酸盐，镁，钙，硫酸盐和磷酸盐。