公开(公告)号：WO2016188951A1

公开(公告)日：2016-12-01

申请号：PCT/EP2016/061569

申请日：2016-05-23

Applicant: GAMBRO LUNDIA AB

Inventor： ROVATTI, Paolo ,  LODI, Carlo Alberto ,  SURACE, Alessandro ,  WALLENBORG, Anders ,  NILSSON, Anders ,  SOLEM, Kristian ,  STERNBY, Jan ,  HERTZ, Thomas

IPC: A61M1/16 ,  A61M1/36

CPC classification number: A61M1/1605 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/1656 ,  A61M1/1666 ,  A61M1/3406 ,  A61M1/3609 ,  A61M2205/128 ,  A61M2230/005 ,  A61M2230/20 ,  A61M2230/65

Abstract: An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line (8) at a set point; the setting of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the blood plasma conductivity and of an adjustment contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate, and phosphate.

Abstract translation: 提供一种体外血液处理装置，包括与血液回路（17）连接的过滤单元（2）和透析液回路（32），制备和调节透析液的组成的准备装置（9） 控制单元（12）被配置为在透析供给管线（8）中将透析液的钠浓度值设定在设定点; 钠浓度的设定包括基于血浆电导率和基于透析中的至少一种物质的浓度的调整贡献项计算钠浓度值作为主要贡献项的代数和的子步骤 在组中选择的液体包括碳酸氢盐，钾，乙酸盐，乳酸盐，柠檬酸盐，镁，钙，硫酸盐和磷酸盐。

公开(公告)号：WO2014076601A1

公开(公告)日：2014-05-22

申请号：PCT/IB2013/059711

申请日：2013-10-28

Applicant: GAMBRO LUNDIA AB

Inventor： FONTANAZZI, Francesco ,  ROSATI, Francesco ,  SURACE, Alessandro

IPC: A61M1/16

CPC classification number: A61M1/367 ,  A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/1613 ,  A61M1/1617 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3334 ,  A61M2205/3393 ,  A61M2209/02 ,  G05B13/04 ,  G05D7/0617 ,  G06F17/10

Abstract: An apparatus for extracorporeal treatment of blood (1) comprising a treatment unit, a blood withdrawal line, a blood return line, a preparation line and a spent dialysate line. A control unit (10) is configured to calculate values of a parameter relating to treatment effectiveness based on measures of the conductivity in the spent dialysate line. The value of the effectiveness parameter is calculated using one or more values representative of the conductivity in the spent dialysate line obtained relying on a mathematical model.

Abstract translation: 一种用于体外血液处理的装置（1），包括处理单元，抽血管线，血液回流管线，制备管线和用过的透析液管线。 控制单元（10）被配置为基于用过的透析液线中的电导率的测量来计算与治疗有效性有关的参数的值。 使用代表根据数学模型获得的用过的透析液线中的电导率的一个或多个值来计算有效性参数的值。

公开(公告)号：WO2020136273A1

公开(公告)日：2020-07-02

申请号：PCT/EP2019/087119

申请日：2019-12-27

Applicant: GAMBRO LUNDIA AB

Inventor： ROVATTI, Paolo ,  SURACE, Alessandro ,  LODI, Carlo, Alberto

IPC: A61M1/16

Abstract: An extracorporeal blood treatment apparatus is provided comprising a filtration unit connected to a blood circuit and to a dialysate circuit, a preparation device for preparing and regulating the composition of the dialysis fluid; a control unit is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line at a set point based on the physician prescription; starting from the initial patient plasma conductivity, estimated at the beginning of the treatment, and based on the target plasma conductivity/sodium concentration which is equivalent to the dialysate conductivity/sodium concentration prescribed, the control unit determines the minimum constant gradient between dialysis fluid and plasma conductivity/concentration to be maintained during treatment to achieve the conductivity/concentration target in the patient plasma at the end of the session.

公开(公告)号：WO2012172398A1

公开(公告)日：2012-12-20

申请号：PCT/IB2012/000534

申请日：2012-03-20

Applicant: GAMBRO LUNDIA AB ,  FONTANAZZI, Francesco ,  SURACE, Alessandro ,  PAOLINI, Francesco

Inventor： FONTANAZZI, Francesco ,  SURACE, Alessandro ,  PAOLINI, Francesco

IPC: A61M1/16

CPC classification number: A61M1/3639 ,  A61M1/16 ,  A61M1/1605 ,  A61M1/1613 ,  A61M1/341 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3393 ,  A61M2205/502 ,  A61M2205/52

Abstract: An apparatus (1) for extracorporeal blood treatment is described, comprising a treatment unit (2), an extracorporeal blood circuit (8), an infusion line (9, 9a, 9b) of a replacement fluid, a dialysis line connected in inlet to the second chamber (4), and a fluid evacuation line (10). The apparatus further comprises sensors for determining a first parameter relating to a patient's blood volume (BV%) a second parameter relating to an ultrafiltration flow rate (UFR) or to a patient's weight loss rate (WLR), a third parameter (Cd, Na) relating to a conductivity or concentration of a liquid crossing the dialysis line and/or the infusion line, and a fourth parameter relating to an infusion flow rate (Q INF ). Lastly, the apparatus comprises a control unit for performing a control procedure comprising receiving, from the sensors, the measured values of the above-cited parameters and calculating, on the basis of the measured values and the prescription values of the variation in blood volume (BV% target ), the weight loss (WL target )> the plasma conductivity or sodium concentration(C target , Na target) , the infusion volume (V INFtarget ), control values to be imposed during a time interval following the control instant.

Abstract translation: 描述了一种用于体外血液处理的装置（1），包括处理单元（2），体外血液回路（8），替换流体的输注管线（9,9a，9b），透析线路连接到入口至 第二室（4）和排液管（10）。 该装置还包括用于确定与患者血液体积（BV％）相关的第一参数的传感器，涉及超滤流率（UFR）或患者体重减轻率（WLR）的第二参数，第三参数（Cd，Na ）涉及与透析线和/或输注线交叉的液体的电导率或浓度，以及与输注流量（QINF）有关的第四参数。 最后，该装置包括用于执行控制程序的控制单元，包括从传感器接收上述参数的测量值，并根据测量值和血量变化的处方值 BV％目标），体重减轻（WLtarget）>等离子体导电率或钠浓度（Ctarget，Natarget），输注体积（VINFtarget），在控制时刻之后的时间间隔内施加的控制值。

公开(公告)号：WO2022253528A1

公开(公告)日：2022-12-08

申请号：PCT/EP2022/062574

申请日：2022-05-10

Applicant: GAMBRO LUNDIA AB

Inventor： ROVATTI, Paolo ,  SURACE, Alessandro

IPC: A61M1/16 ,  A61M1/36

Abstract: A control unit of an apparatus for extracorporeal blood treatment is configured to perform a control procedure comprising: calculating parameter control values to be set during a time interval after the instant in which the control is made, on the basis of actual values and of prescription values of variation in blood volume, ultrafiltration flow rate, concentration of sodium; imposing the parameter control values during the time interval consecutive to the instant in which the control is made such that the actual values of the variation in blood volume track the prescription values of the variation in blood volume over a predetermined treatment time. The control unit is further configured to perform a procedure for automatically estimating/calculating a target plasma conductivity and/or a target concentration of sodium in plasma to be reached at the end of the extracorporeal blood treatment.

公开(公告)号：WO2018095694A1

公开(公告)日：2018-05-31

申请号：PCT/EP2017/077566

申请日：2017-10-27

Applicant: GAMBRO LUNDIA AB

Inventor： WALLENBORG, Anders ,  NILSSON, Anders ,  SOLEM, Kristian ,  HERTZ, Thomas ,  ROVATTI, Paolo ,  LODI, Carlo, Alberto ,  SURACE, Alessandro ,  STERNBY, Jan

IPC: A61M1/16 ,  A61M1/34

Abstract: An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid, and a sensor (11) for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit (12) configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and/or the substitution fluid, measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value of the spent dialysis fluid and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating the dialysis fluid up to the calculating of the initial plasma conductivity being performed maintaining the dialysis fluid conductivity substantially constant.

公开(公告)号：WO2012127298A1

公开(公告)日：2012-09-27

申请号：PCT/IB2012/000537

申请日：2012-03-20

Applicant: GAMBRO LUNDIA AB ,  FONTANAZZI, Francesco ,  SURACE, Alessandro ,  PAOLINI, Francesco

Inventor： FONTANAZZI, Francesco ,  SURACE, Alessandro ,  PAOLINI, Francesco

IPC: A61M1/16

CPC classification number: A61M1/34 ,  A61M1/1605 ,  A61M1/1611 ,  A61M1/3403 ,  A61M1/3406 ,  A61M1/341 ,  A61M1/3413 ,  A61M1/342 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3462 ,  A61M1/3465 ,  A61M2205/3334

Abstract: An apparatus (1 ) for extracorporeal blood treatment is described, comprising a treatment unit (2), an extracorporeal blood circuit (8), an infusion line (9, 9a, 9b) of a replacement fluid, a dialysis line connected in inlet to the second chamber (4), and a fluid evacuation line (10). The apparatus further comprises sensors for determining a first parameter relating to a patient's blood volume (BV%) a second parameter relating to an ultrafiltration flow rate (UFR) or to a patient's weight loss rate (WLR), a third parameter (Cd, Na) relating to a conductivity or concentration of a liquid crossing the dialysis line and/or the infusion line, and a fourth parameter relating to an infusion flow rate (Q INF )- Lastly, the apparatus comprises a control unit for performing a control procedure (50) for regulating a variation in blood volume (BV%) and a setting sequence (200) for imposing a transmembrane pressure (TMP) to values which enable maximising the convective exchanges.

Abstract translation: 描述了一种用于体外血液处理的装置（1），包括处理单元（2），体外血液回路（8），替换流体的输注管线（9,9a，9b），透析线路连接到入口至 第二室（4）和排液管（10）。 该装置还包括用于确定与患者血液体积（BV％）相关的第一参数的传感器，涉及超滤流率（UFR）或患者体重减轻率（WLR）的第二参数，第三参数（Cd，Na ）涉及与透析线和/或输注线交叉的液体的电导率或浓度，以及与输注流量（QINF）有关的第四参数。最后，该装置包括用于执行控制过程的控制单元（50 ），用于调节血容量变化（BV％）和用于施加跨膜压力（TMP）的设定顺序（200）到能够最大化对流交换的值。

公开(公告)号：WO2016188950A1

公开(公告)日：2016-12-01

申请号：PCT/EP2016/061568

申请日：2016-05-23

Applicant: GAMBRO LUNDIA AB

Inventor： ROVATTI, Paolo ,  SURACE, Alessandro ,  LODI, Carlo Alberto ,  WALLENBORG, Anders ,  NILSSON, Anders ,  SOLEM, Kristian ,  STERNBY, Jan ,  HERTZ, Thomas

IPC: A61M1/16 ,  A61M1/36

CPC classification number: A61M1/1607 ,  A61M1/1609 ,  A61M1/1613 ,  A61M1/3609 ,  A61M2205/3317

Abstract: An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid, and a sensor (11) for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit (12) configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and blood trough the filtration unit (2), measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value of the spent dialysis fluid and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating the dialysis fluid up to the calculating of the initial plasma conductivity being performed maintaining the dialysis fluid conductivity substantially constant.

Abstract translation: 提供了一种体外血液处理装置，其包括连接到血液回路（17）和透析液回路（32）的过滤单元（2），用于制备和调节透析液的组成的制备装置（9） 用于测量透析液（即用过的透析液）的电导率的传感器（11）; 控制单元（12），其被配置为设置透析液中的钠浓度，并且在初始设定点设定透析液之后，使透析液和血液循环通过过滤单元（2），测量透析液的初始电导率值 在治疗开始时，基于所测量的用过的透析液的初始电导率值和透析液的相应电导率值，计算初始等离子体电导率的值，将透析液循环至计算 执行初始血浆导电性，维持透析流体导电性基本上恒定。

公开(公告)号：WO2015086631A1

公开(公告)日：2015-06-18

申请号：PCT/EP2014/077104

申请日：2014-12-10

Applicant: GAMBRO LUNDIA AB

Inventor： ROVATTI, Paolo ,  SURACE, Alessandro

IPC: A61M1/14

CPC classification number: A61M1/1611 ,  A61M1/1601 ,  A61M1/1613 ,  A61M1/1652 ,  A61M2205/3576 ,  A61M2205/3584 ,  A61M2205/52 ,  A61M2205/6018 ,  A61M2205/6054

Abstract: A method of operating an extracorporeal blood treatment includes, prior to commencing an extracorporeal blood treatment, reading from a storage device (4a, 5a) stored values of a patient- specific prescription parameter. These stored values relate to a sequence of previous extracorporeal blood treatments. In addition, the method includes processing the stored values of the parameter read from the storage device (4a, 5a) according to a predetermined algorithm to determine a current value of the patient-specific prescription parameter. The current value is then available for the subsequent extracorporeal blood treatment.

Abstract translation: 操作体外血液处理的方法包括在开始体外血液处理之前，从存储装置（4a，5a）读取存储患者特异性处方参数的值。 这些储存值与以前的体外血液治疗的序列有关。 此外，该方法包括根据预定算法处理从存储装置（4a，5a）读取的参数的存储值，以确定患者特定处方参数的当前值。 目前的价值可用于随后的体外血液治疗。

公开(公告)号：WO2022175154A1

公开(公告)日：2022-08-25

申请号：PCT/EP2022/053227

申请日：2022-02-10

Applicant: GAMBRO LUNDIA AB

Inventor： ROVATTI, Paolo ,  SURACE, Alessandro

IPC: A61M1/16 ,  A61M1/36

Abstract: A control unit of an apparatus for extracorporeal blood treatment is configured to perform a control procedure comprising: calculating parameter control values to be set during a time interval after the instant in which the control is made, on the basis of actual values and of prescription values of variation in blood volume, ultrafiltration flow rate, concentration of sodium and/or potassium and heart rate or variation of heart rate of the patient; imposing the parameter control values during the time interval consecutive to the instant in which the control is made such that the actual values of the variation in blood volume track the prescription values of the variation in blood volume over a predetermined treatment time and the actual values of the heart rate or variation of heart rate track the prescription values of the heart rate or variation of heart rate over the predetermined treatment time.