公开(公告)号：WO2020036986A1

公开(公告)日：2020-02-20

申请号：PCT/US2019/046391

申请日：2019-08-13

Applicant: GILEAD SCIENCES, INC.

Inventor： AMMANN, Stephen ,  BACON, Elizabeth M. ,  BRIZGYS, Gediminas ,  CHIN, Elbert ,  CHOU, Chienhung ,  COTTELL, Jeromy J. ,  NDUKWE, Marilyn ,  SHATSKIKH, Marina ,  TAYLOR, James G. ,  WRIGHT, Nathan E. ,  YANG, Zheng-Yu ,  ZIPFEL, Sheila M.

IPC: C07D487/04 ,  A61P29/00 ,  A61K31/5025

Abstract: A compound of Formula (I): (I) pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.

公开(公告)号：WO2021154796A1

公开(公告)日：2021-08-05

申请号：PCT/US2021/015197

申请日：2021-01-27

Applicant: GILEAD SCIENCES, INC.

Inventor： AMMANN, Stephen ,  BRIZGYS, Gediminas ,  CASSIDY, James S. ,  CHIN, Elbert ,  CHOU, Chienhung ,  COTTELL, Jeromy J. ,  HUNG, Chao-I ,  KOLAHDOUZAN, Kavoos ,  SHORE, Daniel G. ,  SZEWCZYK, Suzanne M. ,  TAYLOR, James G. ,  THOMAS-TRAN, Rhiannon ,  WRIGHT, Nathan E. ,  YANG, Zheng-Yu

IPC: C07D405/10 ,  C07D405/14 ,  C07D409/14 ,  C07D493/04 ,  C07D498/04 ,  A61K31/4184 ,  A61K31/4439 ,  A61P1/16 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P13/12 ,  A61P19/02 ,  A61P25/16

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition.

公开(公告)号：WO2020014468A1

公开(公告)日：2020-01-16

申请号：PCT/US2019/041382

申请日：2019-07-11

Applicant: GILEAD SCIENCES, INC.

Inventor： AMMANN, Stephen ,  BACON, Elizabeth M. ,  BRIZGYS, Gediminas ,  CHIN, Elbert ,  CHOU, Chienhung ,  COTTELL, Jeromy J. ,  NDUKWE, Marilyn ,  TAYLOR, James G. ,  WRIGHT, Nathan E. ,  YANG, Zheng-YU ,  ZIPFEL, Sheila M.

IPC: C07D487/04 ,  A61P17/06 ,  A61K31/5025

Abstract: A compound of Formula (I): (I) pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof, wherein the variable substituents are disclosed herein.

公开(公告)号：WO2023039464A1

公开(公告)日：2023-03-16

申请号：PCT/US2022/076099

申请日：2022-09-08

Applicant: GILEAD SCIENCES, INC.

Inventor： AMMANN, Stephen ,  CANALES, Eda Y. ,  CHANG, Weng K. ,  KINFE, Henok H. ,  SCHROEDER, Scott D. ,  LAZERWITH, Scott E. ,  MITCHELL, Michael L. ,  MOAZAMI, Yasamin ,  SHORE, Daniel G.

IPC: A61P29/00 ,  C07D519/00 ,  A61K31/4745

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of an autoimmune disease and/or inflammatory condition, including systemic lupus erythematosus and cutaneous lupus erythematosus.

公开(公告)号：WO2020036979A1

公开(公告)日：2020-02-20

申请号：PCT/US2019/046380

申请日：2019-08-13

Applicant: GILEAD SCIENCES, INC.

Inventor： AMMANN, Stephen ,  BACON, Elizabeth M. ,  BRIZGYS, Gediminas ,  CHIN, Elbert ,  CHOU, Chienhung ,  COTTELL, Jeromy J. ,  NDUKWE, Marilyn ,  TAYLOR, James G. ,  WRIGHT, Nathan E. ,  YANG, Zheng-Yu ,  ZIPFEL, Sheila M.

IPC: A61P29/00 ,  C07D487/04 ,  A61K31/506

Abstract: A compound of Formula (I) pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.

公开(公告)号：WO2020036830A1

公开(公告)日：2020-02-20

申请号：PCT/US2019/046026

申请日：2019-08-09

Applicant: GILEAD SCIENCES, INC.

Inventor： AMMANN, Stephen ,  BACON, Elizabeth M. ,  BRIZGYS, Gediminas ,  CHIN, Elbert ,  CHOU, Chienhung ,  COTTELL, Jeromy J. ,  NDUKWE, Marilyn ,  TAYLOR, James G. ,  WRIGHT, Nathan E. ,  YANG, Zheng-Yu ,  ZIPFEL, Sheila M.

IPC: C07D487/04 ,  A61K31/5025 ,  A61P29/00

Abstract: A compound of Formula (I), pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.