公开(公告)号：WO2018183897A1

公开(公告)日：2018-10-04

申请号：PCT/US2018/025475

申请日：2018-03-30

Applicant: GRAIL, INC.

Inventor： EATTOCK, Nicholas ,  JUNG, Byoungsok ,  WILLIAMS, Justice

IPC: C12Q1/6806

CPC classification number: C12Q1/6874 ,  C12Q1/6806 ,  C12Q2533/101 ,  C12Q2535/122

Abstract: Aspects of the invention include methods for preparing an enriched sequencing library. In some embodiments, the methods involve preparing a sequencing library that is enriched for AT-rich sequences. In certain embodiments, the methods involve determining a presence or an absence of cancer, determining a cancer stage, monitoring cancer progression, and/or determining a cancer classification in a subject by analyzing an enriched sequencing library.

公开(公告)号：WO2019126803A1

公开(公告)日：2019-06-27

申请号：PCT/US2018/067386

申请日：2018-12-21

Applicant: GRAIL, INC. ,  VIJAYA SATYA, Ravi ,  GNERRE, Sante ,  EATTOCK, Nicholas ,  JI, Lijuan ,  TOM, Curtis

Inventor： VIJAYA SATYA, Ravi ,  GNERRE, Sante ,  EATTOCK, Nicholas ,  JI, Lijuan ,  TOM, Curtis

IPC: C12Q1/6855 ,  C12Q1/6848

CPC classification number: G16B35/10 ,  C12Q1/6848 ,  C12Q1/6855 ,  C12Q1/6881 ,  C12Q1/6886 ,  G16B25/20 ,  G16B30/00 ,  C12Q2521/325 ,  C12Q2521/531 ,  C12Q2525/155 ,  C12Q2525/173 ,  C12Q2525/191 ,  C12Q2527/101 ,  C12Q2535/122 ,  C12Q2563/179

Abstract: Methods for preparing sequencing libraries from a DNA-containing test sample, as well as methods for reducing the occurrence of edge errors prior to sequencing, are provided.