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公开(公告)号：WO2022191829A1
公开(公告)日：2022-09-15
申请号：PCT/US2021/021662
申请日：2021-03-10
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： SHKOLNIKOV, Viktor , GOVYADINOV, Alexander , KORNILOVICH, Pavel
Abstract: The present disclosure is drawn to microfluidic valves and microfluidic devices that include the microfluidic valves. In one example, a microfluidic valve can include a microfluidic channel, a solid gas-generating material in the microfluidic channel, and an electric initiator adjacent to the solid gas-generating material. The solid gas-generating material can be chemically reactive to form a gas. The electric initiator can be configured to initiate a chemical reaction of the solid gas-generating material to form the gas when an electric current is applied to the electric initiator.
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公开(公告)号：WO2022019893A1
公开(公告)日：2022-01-27
申请号：PCT/US2020/042944
申请日：2020-07-21
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： SHKOLNIKOV, Viktor , GOVYADINOV, Alexander
IPC: C12M1/12 , C12M1/34 , C12M3/06 , C12Q1/6806 , C12Q1/6825 , C12Q1/686 , B81B1/00 , B81B7/02
Abstract: An example method, consistent with the present disclosure, includes receiving in a microfluidic channel, a fluid sample and a reagent, where the reagent includes a reporter nucleic acid labeled with a detectable ligand. The method further includes identifying a target nucleic acid in the fluid sample using a guide ribonucleic acid (gRNA) and a programmable nuclease immobilized in a side channel fluidically coupled to the microfluidic channel. Responsive to identifying the target nucleic acid in the fluid sample, the method includes causing cleavage of the detectable ligand, and detecting the detectable ligand from the cleaved reporter nucleic acid in the side channel.
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公开(公告)号：WO2021150212A1
公开(公告)日：2021-07-29
申请号：PCT/US2020/014448
申请日：2020-01-21
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： GOVYADINOV, Alexander , ELY, Hilary , DAHLGREN, Brett E. , CHOY, Si-Lam J. , TORNIAINEN, Erik
IPC: G01N21/01 , G01N21/64 , C12Q1/6844 , B81B1/00 , B81B7/02
Abstract: A microfluidic reaction chamber with a reaction chamber circuit includes a microfluidic reaction chamber to contain a reaction fluid for amplification of nucleic acids, and a reaction chamber circuit disposed within the microfluidic reaction chamber. The microfluidic reaction chamber includes a base wall, a top wall parallel to the base wall and defined in part by a transparent lid, a first side wall, and a second side wall. The reaction chamber circuit is disposed within the microfluidic reaction chamber, and includes a top surface, a bottom surface, a first side wall, and a second side wall. The reaction chamber circuit is in fluidic contact with the reaction fluid and includes a photodetector to detect a fluorescence signal from a labeled fluorescent tag in the reaction fluid.
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公开(公告)号：WO2020159538A1
公开(公告)日：2020-08-06
申请号：PCT/US2019/016332
申请日：2019-02-01
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： GOVYADINOV, Alexander , SHKOLNIKOV, Viktor
Abstract: In one example in accordance with the present disclosure, a cell analysis system is described. The cell analysis system includes at least one cell analysis device. Each cell analysis device includes a channel to serially feed individual cells from a volume of cells into a lysing chamber. The cell analysis device also includes at least one feedback-controlled lysing element in the lysing chamber to agitate a cell. The cell analysis system also includes a controller to analyze the cell. The controller includes a lysate analyzer to analyze properties of the lysate and a rupture analyzer to analyze parameters of an agitation when a cell membrane ruptures.
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公开(公告)号：WO2020032970A1
公开(公告)日：2020-02-13
申请号：PCT/US2018/046205
申请日：2018-08-10
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： SHKOLNIKOV, Viktor , GOVYADINOV, Alexander
IPC: C12M1/12 , C12M1/34 , C12M3/06 , C12N1/06 , C12Q1/68 , B01D35/26 , G01N27/26 , G01N1/34 , G01N35/10
Abstract: In one example in accordance with the present disclosure, a cellular analytic system is described. The cellular analytic system includes a series of analytic devices. Each analytic device includes 1) a separator to separate a cellular particle from a surrounding fluid, 2) an analyzer coupled to a first outlet of the separator to analyze the surrounding fluid, and 3) at least one lysing device coupled to at least a second outlet of the separator to rupture a membrane of the cellular particle. An outlet of the lysing device is fluidly coupled to a separator of a downstream analytic device.
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Patent Agency Ranking
公开(公告)号：WO2020018073A1
公开(公告)日：2020-01-23
申请号：PCT/US2018/042408
申请日：2018-07-17
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： KORNILOVICH, Pavel , LAHMANN, John , GOVYADINOV, Alexander , HAMMERSTAD, Diane R
IPC: B41J2/015
Abstract: An example device includes a droplet ejector including a nozzle to eject droplets of a fluid and a target medium to receive the droplets of the fluid. The target medium is separated from the droplet ejector by a gap to be traversed by the droplets. The example device further includes a frame affixing the target medium to the droplet ejector. The target medium is immovably held with respect to the droplet ejector.
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公开(公告)号：WO2018186881A1
公开(公告)日：2018-10-11
申请号：PCT/US2017/026562
申请日：2017-04-07
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： TORNIAINEN, Erik D. , GOVYADINOV, Alexander , KORNILOVICH, Pavel , MARKEL, David P.
Abstract: The present disclosure is drawn to inertial pumps. An inertial pump can include a microfluidic channel, a fluid actuator located in the microfluidic channel, and a check valve located in the microfluidic channel. The check valve can include a moveable valve element, a narrowed channel segment located upstream of the moveable valve element, and a blocking element formed in the microfluidic channel downstream of the moveable valve element. The narrowed channel segment can have a width less than a width of the moveable valve element so that the moveable valve element can block fluid flow through the check valve when the moveable valve element is positioned in the narrowed channel segment. The blocking element can be configured such that the blocking element constrains the moveable valve element within the check valve while also allowing fluid flow when the moveable valve element is positioned against the blocking element.
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公开(公告)号：WO2018151724A1
公开(公告)日：2018-08-23
申请号：PCT/US2017/017983
申请日：2017-02-15
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： KORNILOVICH, Pavel , GOVYADINOV, Alexander , MCGUINNESS, Nick
Abstract: An apparatus may include a first microfluidic valve coupled between a first reservoir and a fluid channel. The first microfluidic valve may include a fluid agitator to break a meniscus formed at an air-fluid interface and release fluid from the first reservoir into the fluid channel in response to an electrical signal. The apparatus may also include a second microfluidic valve coupled between a second reservoir and the fluid channel. Fluid from the first reservoir and fluid from the second reservoir mix in the fluid channel.
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公开(公告)号：WO2018022105A1
公开(公告)日：2018-02-01
申请号：PCT/US2016/044833
申请日：2016-07-29
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： MCGUINNESS, Nicholas , GOVYADINOV, Alexander , YAMASHITA, Tsuyoshi , TORNIAINEN, Erik D , MARKEL, David P.
Abstract: A fluid ejection device includes a fluid slot, two laterally adjacent fluid ejection chambers each having a drop ejecting element therein, a fluid circulation path communicated with the fluid slot and each of the two laterally adjacent fluid ejection chambers, and a fluid circulating element within the fluid circulation path, with the fluid circulating element laterally adjacent at least one of the two laterally adjacent fluid ejection chambers, and the two laterally adjacent fluid ejection chambers to substantially simultaneously eject drops of fluid therefrom such that the drops of fluid are to coalesce during flight.
Abstract translation: 流体喷射装置包括流体槽，两个横向相邻的流体喷射腔室，每个流体喷射腔室中均具有液滴喷射元件，流体循环路径与流体槽连通，并且两个横向相邻的流体喷射腔室中的每一个 以及流体循环路径内的流体循环元件，其中流体循环元件横向地邻接两个横向相邻的流体喷射室中的至少一个，并且两个横向相邻的流体喷射室基本上同时地从其中喷射液滴，使得 在飞行过程中液滴会聚结。
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公开(公告)号：WO2017184134A1
公开(公告)日：2017-10-26
申请号：PCT/US2016/028478
申请日：2016-04-20
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： GE, Ning , ROGACS, Anita , SHKOLNIKOV, Viktor , GOVYADINOV, Alexander
Abstract: A surface enhanced Raman scattering (SERS) sensor may include a substrate, an electrically conductive layer having a first portion spaced from a second portion by a gap, an electrically resistive layer in contact with and extending between the first portion and the second portion of the electrically conductive layer to form an electrically resistive bridge across the gap that heats the nano fingers in response to electrical current flowing across the bridge from the first portion to the second portion and nano fingers extending upward from the bridge.
Abstract translation: 表面增强拉曼散射（SERS）传感器可以包括衬底，导电层，导电层具有与第二部分隔开间隙的第一部分，与第一部分接触并在第一部分与第二部分之间延伸的电阻层 所述导电层的第一部分和第二部分形成横跨所述间隙的电阻桥，所述电桥响应于流过所述桥从所述第一部分到所述第二部分的电流加热所述纳米指，并且从所述桥向上延伸的纳米指
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