公开(公告)号：WO2016100932A1

公开(公告)日：2016-06-23

申请号：PCT/US2015/066908

申请日：2015-12-18

Applicant: IMMUSOFT CORPORATION

Inventor： SCHOLZ, Matthew Rein ,  HERBIG, Eric J. ,  XU, Mei ,  DE LAAT, Rian

IPC: C12N5/00 ,  C12N5/071 ,  C12N5/0781

CPC classification number: C12N5/0635 ,  A61K35/17 ,  C12N5/0087 ,  C12N2501/056 ,  C12N2501/23 ,  C12N2501/2302 ,  C12N2501/2304 ,  C12N2501/2306 ,  C12N2501/231 ,  C12N2501/2315 ,  C12N2501/2321 ,  C12N2501/24 ,  C12N2501/52 ,  C12N2501/599 ,  C12N2501/999 ,  C12N2510/00 ,  C12N2510/02

Abstract: The present disclosure relates to genetically modified B cells, including memory cells, differentiated to plasmablasts or plasma cells useful for long term in vivo expression of a transgene, such as a specific antibody or other protein therapeutic. Also disclosed are methods of producing the cells and methods of treatment.

Abstract translation: 本公开涉及分化为可用于转基因（例如特异性抗体或其它蛋白质治疗剂）的长期体内表达的浆细胞或浆细胞的记忆细胞的遗传修饰的B细胞。 还公开了生产细胞的方法和治疗方法。

公开(公告)号：WO2014152832A1

公开(公告)日：2014-09-25

申请号：PCT/US2014/027910

申请日：2014-03-14

Applicant: IMMUSOFT CORPORATION

Inventor： XU, Mei ,  SCHOLZ, Matthew Rein ,  HERBIG, Eric J.

IPC: C12P21/04 ,  C12N5/071 ,  C12N5/00

CPC classification number: C12N5/0635 ,  C12N2501/2302 ,  C12N2501/2306 ,  C12N2501/231 ,  C12N2501/2315 ,  C12N2501/24 ,  C12N2501/52 ,  C12N2510/02

Abstract: The present disclosure relates to the in vitro differentiation of memory B cells to plasmablasts or plasma cells and genetic modification of these cells to express a protein of interest, such as a specific antibody or other protein therapeutic.

Abstract translation: 本公开涉及记忆B细胞到浆细胞或浆细胞的体外分化以及这些细胞的遗传修饰以表达目的蛋白，例如特异性抗体或其它蛋白质治疗剂。