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公开(公告)号：WO2018152220A1
公开(公告)日：2018-08-23
申请号：PCT/US2018/018205
申请日：2018-02-14
Applicant: INCYTE CORPORATION
Inventor： SOKOLSKY, Alexander , VECHORKIN, Oleg , LIU, Kai , PAN, Jun , YAO, Wenqing , YE, Qinda
IPC: C07D471/04 , A61K31/437 , A61P35/00
Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
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2.发明申请PYRAZOLOPYRIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER 审中-公开作为HPK1调节剂的吡唑并吡啶衍生物及其用于治疗癌症的用途
公开(公告)号：WO2018049214A1
公开(公告)日：2018-03-15
申请号：PCT/US2017/050757
申请日：2017-09-08
Applicant: INCYTE CORPORATION
Inventor： LIU, Kai , PAN, Jun , SOKOLSKY, Alexander , VECHORKIN, Oleg , YE, Qinda , YAO, Wenqing , YE, Hai-Fen
IPC: C07D471/04 , A61K31/437 , A61P35/00
Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
Abstract translation: 公开了式（I）化合物，使用所述化合物抑制HPK1活性的方法和包含所述化合物的药物组合物。 该化合物可用于治疗，预防或改善与HPK1活性相关的疾病或病症，如癌症。
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3.发明申请
公开(公告)号：WO2018049200A1
公开(公告)日：2018-03-15
申请号：PCT/US2017/050737
申请日：2017-09-08
Applicant: INCYTE CORPORATION
Inventor： YE, Hai-Fen , VECHORKIN, Oleg , PAN, Jun , LIU, Kai , SOKOLSKY, Alexander , WANG, Anlai , YE, Qinda , YAO, Wenqing
IPC: C07D471/04 , A61K31/437 , A61P35/00
Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
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4.发明申请PYRAZOLOPYRIDONE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER 审中-公开作为HPK1调节剂的吡唑并吡啶酮衍生物及其用于治疗癌症的用途
公开(公告)号：WO2018049191A1
公开(公告)日：2018-03-15
申请号：PCT/US2017/050727
申请日：2017-09-08
Applicant: INCYTE CORPORATION
Inventor： YE, Qinda , LIU, Kai , PAN, Jun , SOKOLSKY, Alexander , VECHORKIN, Oleg , YAO, Wenqing
IPC: C07D471/04 , A61K31/437 , A61P35/00
Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
Abstract translation: 公开了式（I）化合物，使用所述化合物抑制HPK1活性的方法和包含所述化合物的药物组合物。 该化合物可用于治疗，预防或改善与HPK1活性相关的疾病或病症，如癌症。
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5.发明申请
公开(公告)号：WO2018049214A9
公开(公告)日：2018-03-15
申请号：PCT/US2017/050757
申请日：2017-09-08
Applicant: INCYTE CORPORATION
Inventor： LIU, Kai , PAN, Jun , SOKOLSKY, Alexander , VECHORKIN, Oleg , YE, Qinda , YAO, Wenqing , YE, Hai-Fen
IPC: C07D471/04 , A61K31/437 , A61P35/00
Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
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Patent Agency Ranking6.发明申请PYRAZOLOPYRIMIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER 审中-公开作为HPK1调节剂的吡唑并嘧啶衍生物及其用于治疗癌症的用途
公开(公告)号：WO2018049152A1
公开(公告)日：2018-03-15
申请号：PCT/US2017/050669
申请日：2017-09-08
Applicant: INCYTE CORPORATION , YE, Hai-Fen , HUMMEL, Joshua
Inventor： YE, Hai-Fen , HUMMEL, Joshua , VECHORKIN, Oleg , LIU, Kai , PAN, Jun , SOKOLSKY, Alexander , YE, Qinda , YAO, Wenqing
IPC: C07D487/04 , A61K31/519 , A61P35/00
Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
Abstract translation: 公开了式（I）化合物，使用所述化合物抑制HPK1活性的方法和包含所述化合物的药物组合物。 该化合物可用于治疗，预防或改善与HPK1活性相关的疾病或病症，如癌症。
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公开(公告)号：WO2022046989A1
公开(公告)日：2022-03-03
申请号：PCT/US2021/047687
申请日：2021-08-26
Applicant: INCYTE CORPORATION
Inventor： LIU, Kai , DOUTY, Brent , LEVY, Daniel , WU, Liangxing , YAO, Wenqing , YUE, Eddy W.
IPC: A61P35/00 , C07D471/14 , A61K31/473
Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.
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8.发明申请
公开(公告)号：WO2018049152A8
公开(公告)日：2018-03-15
申请号：PCT/US2017/050669
申请日：2017-09-08
Applicant: INCYTE CORPORATION
Inventor： YE, Hai-Fen , HUMMEL, Joshua , VECHORKIN, Oleg , LIU, Kai , PAN, Jun , SOKOLSKY, Alexander , YE, Qinda , YAO, Wenqing
IPC: C07D487/04 , A61K31/519 , A61P35/00
Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
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公开(公告)号：WO2019051199A1
公开(公告)日：2019-03-14
申请号：PCT/US2018/049908
申请日：2018-09-07
Applicant: INCYTE CORPORATION
Inventor： VECHORKIN, Oleg , ATASOYLU, Onur , YE, Hai Fen , LIU, Kai , ZHANG, Ke , YAO, Wenqing
IPC: C07D401/14 , C07D405/14 , C07D231/56 , C07D401/04 , C07D403/04 , C07D405/10 , C07D413/04 , C07D417/04 , A61P35/00 , A61K31/416
CPC classification number: A61K31/416 , A61K31/454 , A61P35/00 , C07D231/56 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/10 , C07D405/14 , C07D413/04 , C07D417/04
Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.
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公开(公告)号：WO2022182839A1
公开(公告)日：2022-09-01
申请号：PCT/US2022/017654
申请日：2022-02-24
Applicant: INCYTE CORPORATION
Inventor： SHEPARD, Stacey , COLE, Charles , FALAHATPISHEH, Nikoo , LIU, Kai , SHAO, Lixin , VRUBLIAUSKAS, Darius , WU, Liangxing , YAO, Wenqing , YUE, Eddy, W.
IPC: C07D471/20 , C07D471/22 , C07D491/22 , C07D519/00 , C07B59/00 , A61P35/00 , A61P35/02 , A61K31/438
Abstract: The present application provides spirocyclic lactam compounds of Formula I that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.
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