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    INTERLEUKIN-17F ANTIBODIES AND OTHER IL-17F SIGNALING ANTAGONISTS AND USES THEREFOR
    1.
    发明申请
    INTERLEUKIN-17F ANTIBODIES AND OTHER IL-17F SIGNALING ANTAGONISTS AND USES THEREFOR 审中-公开
    白细胞介素-17F抗体及其他IL-17F信号拮抗剂及其用途

    公开(公告)号：WO2006088833A2

    公开(公告)日：2006-08-24

    申请号：PCT/US2006/005111

    申请日：2006-02-14

    Applicant: WYETH ,  CARRENO, Beatriz, M. ,  COLLINS, Mary ,  WRIGHT, Jill, F. ,  WOLFMAN, Neil, M. ,  ARAI, Maya ,  JACOBS, Kenneth ,  LU, Zhijian ,  GUO, Yongjing ,  QIU, Yongchang

    Inventor： CARRENO, Beatriz, M. ,  COLLINS, Mary ,  WRIGHT, Jill, F. ,  WOLFMAN, Neil, M. ,  ARAI, Maya ,  JACOBS, Kenneth ,  LU, Zhijian ,  GUO, Yongjing ,  QIU, Yongchang

    IPC: C07K16/24 ,  C07K16/28 ,  C07K14/54 ,  C07K14/715 ,  C12N15/11 ,  G01N33/68 ,  A61K39/39 ,  A61K39/395 ,  A61P37/00 ,  A61P29/00 ,  A61K38/20

    CPC classification number: C07K16/244 ,  A61K38/00 ,  A61K2039/505 ,  A61K2039/55527 ,  C07K14/54 ,  C07K14/7155 ,  C07K16/2866 ,  C07K2317/76 ,  C07K2319/30 ,  C12N15/1138 ,  G01N33/6869

    Abstract: The present invention provides isolated and purified polynucleotides and polypeptides related to the IL-17F signaling pathway. The invention also provides antibodies to IL-17F homodimers and IL-17A/IL-17F heterodimers, and methods of isolating and purifying members of the IL-17 family, including IL-17A/IL-17F heterodimers, from a natural source. The present invention also is directed to novel methods for diagnosing, prognosing, monitoring the progress of, and treating and/or preventing disorders related to IL-17F signaling, i.e., IL-17F-associated disorders, including, but not limited to, inflammatory disorders, such as autoimmune diseases (e.g., arthritis (including rheumatoid arthritis), psoriasis, systemic lupus erythematosus, and multiple sclerosis), respiratory diseases (e.g., COPD, cystic fibrosis, asthma, allergy), transplant rejection (including solid organ transplant rejection), and inflammatory bowel diseases or disorders (IBDs, e.g., ulcerative colitis, Crohn's disease). The present invention is further directed to novel therapeutics and therapeutic targets, and to methods of screening and assessing test compounds for the intervention (treatment) and prevention of disorders related to IL-17F signaling.

    Abstract translation: 本发明提供与IL-17F信号通路相关的分离和纯化的多核苷酸和多肽。 本发明还提供了对IL-17F同源二聚体和IL-17A / IL-17F异二聚体的抗体，以及从天然来源分离和纯化IL-17家族成员（包括IL-17A / IL-17F异源二聚体）的方法。 本发明还涉及用于诊断，预后，监测与IL-17F信号传导相关的疾病的进展和/或预防的新方法，即IL-17F相关疾病，包括但不限于炎性 诸如自身免疫性疾病（例如关节炎（包括类风湿性关节炎），牛皮癣，系统性红斑狼疮和多发性硬化症），呼吸系统疾病（例如COPD，囊性纤维化，哮喘，过敏），移植排斥（包括实体器官移植排斥 ）和炎症性肠病或疾病（IBD，例如溃疡性结肠炎，克罗恩病）。 本发明还涉及新的治疗和治疗靶标，以及筛选和评估用于干预（治疗）的试验化合物和预防与IL-17F信号传导相关的紊乱的方法。

    DECORATIVE LAMINATED MIRROR DOOR
    2.
    发明申请
    DECORATIVE LAMINATED MIRROR DOOR 审中-公开
    装饰层压门镜

    公开(公告)号：WO2005103431A1

    公开(公告)日：2005-11-03

    申请号：PCT/IB2005/001510

    申请日：2005-04-18

    Applicant: JACOBS, Kenneth

    Inventor： JACOBS, Kenneth

    IPC: E06B3/70

    CPC classification number: E06B3/7001 ,  B44C5/0407

    Abstract: An inexpensive, light-weight decorative door panel includes a glass panel (90) that substantially defines a height and width of the door panel (30,40). One or more thin decorative sheets (100) are laminated to the front surface (90a) of the glass panel (90). Trim pieces (110,120) are applied to the peripheral intersections between the sheets (100) and the front surface (90a) such that the decorative door panel (30,40) appears to comprise a combination of discrete door panels. A plurality of these decorative door panels (30) are movably or fixedly mounted to a mounting assembly (20) to create a room partition.

    Abstract translation: 一种价格便宜，重量轻的装饰门板包括基本上限定门板（30,40）的高度和宽度的玻璃面板（90）。 一个或多个薄的装饰片（100）被层压到玻璃面板（90）的前表面（90a）上。 修剪件（110,120）被施加到片材（100）和前表面（90a）之间的周边交叉处，使得装饰性门板（30,40）看起来包括离散门板的组合。 多个这些装饰门板（30）可移动地或固定地安装到安装组件（20）上以形成房间隔板。

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