公开(公告)号：WO2014164363A1

公开(公告)日：2014-10-09

申请号：PCT/US2014/022141

申请日：2014-03-07

Applicant: KONA MEDICAL, INC. ,  ZHANG, Jimin ,  GERTNER, Michael

Inventor： ZHANG, Jimin ,  GERTNER, Michael

IPC: A61B5/05 ,  A61N7/00

CPC classification number: A61B8/4494 ,  A61B6/12 ,  A61B6/487 ,  A61B8/0841 ,  A61B8/085 ,  A61B8/4209 ,  A61B8/4245 ,  A61B8/4254 ,  A61B8/4281 ,  A61B8/4416 ,  A61B2017/00725 ,  A61B2018/00023 ,  A61B2034/2063 ,  A61B2090/378 ,  A61B2090/3937 ,  A61B2090/395 ,  A61N7/02 ,  A61N2007/0065 ,  A61N2007/0082 ,  A61N2007/0091 ,  A61N2007/0095

Abstract: A system to apply ultrasound energy to a region surrounding blood flow in a blood vessel from a position outside a patient includes: a therapeutic ultrasound transducer comprising a plurality of transducer elements; and a processor configured to control the plurality of transducer elements; wherein the processor is configured to change phase inputs to the transducer elements to move a focus of the transducer at least 1 cm in a first plane which is substantially along a plane of the transducer elements of the therapeutic ultrasound transducer and at least 1 cm in a second plane orthogonal to the first plane; and wherein the processor is further configured to position the focus of the transducer in sequential positions offset from the blood flow in the blood vessel according to a pattern pre-determined by an operator of the system.

Abstract translation: 将超声波能量施加到患者外部位置处的血管周围的血流周围的区域的系统包括：包括多个换能器元件的治疗性超声换能器; 以及处理器，被配置为控制所述多个换能器元件; 其中所述处理器被配置为改变到所述换能器元件的相位输入，以使所述换能器的焦点在基本上沿着所述治疗性超声换能器的换能器元件的平面的第一平面中移动至少1cm，并且在 与第一平面正交的第二平面; 并且其中所述处理器还被配置为根据由所述系统的操作者预先确定的模式将所述换能器的焦点定位在与所述血管中的血流偏离的顺序位置。

公开(公告)号：WO2012125172A1

公开(公告)日：2012-09-20

申请号：PCT/US2011/033337

申请日：2011-04-20

Applicant: GERTNER, Michael ,  PEROZEK, David ,  ZHANG, Jimin ,  SABET, Arash ,  KONA MEDICAL, INC.

Inventor： GERTNER, Michael ,  PEROZEK, David ,  ZHANG, Jimin ,  SABET, Arash

IPC: A61N7/00

CPC classification number: A61N7/02 ,  A61B6/506 ,  A61B17/22012 ,  A61B2017/00106 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2090/374 ,  A61B2090/3762 ,  A61N2007/003 ,  A61N2007/0043 ,  A61N2007/0091 ,  A61N2007/0095

Abstract: A system for applying high intensity ultrasound energy to a nerve surrounding an artery of a patient includes a piezoelectric array comprising a plurality of ultrasound elements, a controller configured to individually control a phasing of each of the ultrasound elements, a platform on which the ultrasound elements are coupled, wherein the platform is configured to support at least a part of the patient, a programmable generator configured to generate an output power for at least one of the ultrasound elements, and a programmable processor configured to process a signal transmitted from one of the ultrasound elements and reflected back from tissue, and determine a tissue characteristic based on the reflected signal.

Abstract translation: 将高强度超声能量施加到患者动脉周围的神经的系统包括包括多个超声元件的压电阵列，被配置为单独地控制每个超声元件的定相的控制器，其中超声波元件 耦合，其中所述平台被配置为支持所述患者的至少一部分，被配置为为所述超声波元件中的至少一个产生输出功率的可编程发生器，以及被配置为处理从所述超声波元件之一发送的信号的可编程处理器 超声元件并从组织反射回来，并且基于反射信号确定组织特征。

公开(公告)号：WO2017007450A1

公开(公告)日：2017-01-12

申请号：PCT/US2015/039258

申请日：2015-07-06

Applicant: KONA MEDICAL, INC.

Inventor： SABAT, Arash ,  PEROZEK, David M. ,  GERTNER, Michael ,  ZHANG, Jimin

IPC: A61G13/08

CPC classification number: A61G13/08 ,  A61G13/104 ,  A61G13/105 ,  A61G13/122 ,  A61G13/123 ,  A61G13/126 ,  A61G2203/74 ,  A61G2210/50

Abstract: An integrated patient platform system and method for performing medical procedures below a patient's body is disclosed. In some embodiments, a superior level surface of an integrated patient platform is configured to support a patient, lying in a prone or supine position, and an inferior level surface of the integrated patient platform is configured to support one or more medical procedure components. The superior level surface includes an aperture disposed therethrough. At least a portion of the aperture forms an examination window that is adjustable in size and position and configured to receive a portion of a patient over or in the examination window. A medical procedure component may be positioned on the inferior level surface to contact or otherwise interface with the portion of the patient positioned over or in the examination window.

Abstract translation: 公开了一种用于在患者身体下进行医疗程序的综合患者平台系统和方法。 在一些实施例中，综合患者平台的上级表面被配置为支撑位于俯卧位或仰卧位的患者，并且综合患者平台的下级表面被配置为支撑一个或多个医疗程序组件。 上级表面包括通过其设置的孔。 孔的至少一部分形成检查窗口，该检查窗口在尺寸和位置上是可调节的，并且构造成用于将患者的一部分接纳在检查窗口上或检查窗口中。 医疗处理部件可以位于下部水平表面上，以与定位在检查窗口上方或检查窗口中的患者的部分接触或以其他方式接触。

公开(公告)号：WO2014018027A1

公开(公告)日：2014-01-30

申请号：PCT/US2012/048050

申请日：2012-07-25

Applicant: APPLIED MATERIALS, INC. ,  XU, Kun ,  ZHANG, Jimin ,  MAI, David H. ,  JEW, Stephen ,  SHEN, Shih-Haur Walters ,  WANG, Zhihong ,  OSTERHELD, Thomas H. ,  TU, Wen-Chiang ,  LAM, Gary Ka Ho ,  KITAJIMA, Tomohiko

Inventor： XU, Kun ,  ZHANG, Jimin ,  MAI, David H. ,  JEW, Stephen ,  SHEN, Shih-Haur Walters ,  WANG, Zhihong ,  OSTERHELD, Thomas H. ,  TU, Wen-Chiang ,  LAM, Gary Ka Ho ,  KITAJIMA, Tomohiko

IPC: H01L21/304

CPC classification number: B24B37/015 ,  H01L21/3212

Abstract: Methods for chemical mechanical polishing (CMP) of semiconductor substrates, and more particularly to temperature control during such chemical mechanical polishing are provided. In one aspect, the method comprises polishing the substrate with a polishing surface during a polishing process to remove a portion of the conductive material, repeatedly monitoring a temperature of the polishing surface during the polishing process, and exposing the polishing surface to a rate quench process in response to the monitored temperature so as to achieve a target value for the monitored temperature during the polishing process.

Abstract translation: 提供半导体衬底的化学机械抛光（CMP）的方法，更具体地说，涉及这种化学机械抛光时的温度控制。 一方面，该方法包括在抛光过程中用抛光表面抛光衬底以去除一部分导电材料，在抛光过程中重复地监测抛光表面的温度，并将抛光表面暴露于速率骤冷过程 响应于所监测的温度，以便在抛光过程中达到监测温度的目标值。

公开(公告)号：WO2007009118A3

公开(公告)日：2007-01-18

申请号：PCT/US2006/027688

申请日：2006-07-13

Applicant: ACOUSTX CORPORATION ,  SEKINS, K. Michael ,  PEROZEK, David ,  ZHANG, Jimin ,  KOOK, John ,  CALDWELL, Ed ,  EMERY, Charles ,  PEDERSEN, Robert

Inventor： SEKINS, K. Michael ,  PEROZEK, David ,  ZHANG, Jimin ,  KOOK, John ,  CALDWELL, Ed ,  EMERY, Charles ,  PEDERSEN, Robert

IPC: H03G1/00 ,  A61N7/02 ,  A61B17/22 ,  A61B8/14 ,  B06B1/02

Abstract: An inflatable cuff having integrated ultrasound transducers (25) is used to effect hemostasis of deep bleeding wounds in limbs. The cuff includes a chamber defined by a bladder (30) or a series of dams into which a fluid may be introduced and pressurized. The pressure of the fluid stops or slows bleeding while high intensity focused ultrasound is applied to effect hemostasis. The fluid may also serve as an acoustic couplant between the limb and the ultrasound transducers (25). The transducers (25) may be electrostrictive transducers. Diodes may be used to reduce parallel capacitive loading in the transducer array. Bypass capacitors using the electrostrictive material may also be used.

公开(公告)号：WO2012019044A2

公开(公告)日：2012-02-09

申请号：PCT/US2011/046646

申请日：2011-08-04

Applicant: APPLIED MATERIALS, INC. ,  HU, Xiaoyuan ,  WANG, Zhihong ,  LEE, Harry Q. ,  ZHU, Zhize ,  DAVID, Jeffrey Drue ,  BENVEGNU, Dominic J. ,  ZHANG, Jimin ,  TU, Wen-Chiang

Inventor： HU, Xiaoyuan ,  WANG, Zhihong ,  LEE, Harry Q. ,  ZHU, Zhize ,  DAVID, Jeffrey Drue ,  BENVEGNU, Dominic J. ,  ZHANG, Jimin ,  TU, Wen-Chiang

IPC: H01L21/304 ,  H01L21/66

CPC classification number: B24B37/013 ,  B24B37/042 ,  B24B37/107 ,  B24B37/205 ,  B24B49/045 ,  B24B49/12

Abstract: A method of controlling polishing includes storing a library having a plurality of reference spectra, polishing a substrate, measuring a sequence of spectra of light from the substrate during polishing, for each measured spectrum of the sequence of spectra, finding a best matching reference spectrum using a matching technique other than sum of squared differences to generate a sequence of best matching reference spectra, and determining at least one of a polishing endpoint or an adjustment for a polishing rate based on the sequence of best matching reference spectra. Finding a best matching reference spectrum may include performing a cross-correlation of the measured spectrum with each of two or more of the plurality of reference spectra from the library and selecting a reference spectrum with the greatest correlation to the measured spectrum as a best matching reference spectrum.

Abstract translation: 控制抛光的方法包括存储具有多个参考光谱的库，抛光衬底，在抛光期间测量来自衬底的光的光谱序列，对于光谱序列的每个测量光谱 ，使用不同于平方差平方和的匹配技术来找到最佳匹配参考谱以产生最佳匹配参考谱的序列，以及基于最佳匹配序列来确定抛光终点或抛光速率的调整中的至少一个 参考光谱。 寻找最佳匹配参考光谱可以包括执行测量光谱与来自库的多个参考光谱中的两个或更多个中的每一个的互相关，并选择与测量光谱具有最大相关性的参考光谱作为最佳匹配参考 谱。

公开(公告)号：WO2008005951A3

公开(公告)日：2008-01-10

申请号：PCT/US2007/072690

申请日：2007-07-02

Applicant: APPLIED MATERIALS, INC. ,  BENVEGNU, Dominic ,  SWEDEK, Boguslaw ,  ZHANG, Jimin

Inventor： BENVEGNU, Dominic ,  SWEDEK, Boguslaw ,  ZHANG, Jimin

IPC: B24B49/12

Abstract: A polishing pad has an opaque polishing layer with an aperture therethrough and a polishing surface, and a solid light-transmissive window in the aperture. The solid light-transmissive window includes an outer portion secured to the polishing layer and an inner portion secured to the outer portion. The outer portion has a upper surface recessed relative to the polishing surface, whereas the inner portion has an upper surface that is substantially co-planar with the polishing surface.

公开(公告)号：WO2007047993A2

公开(公告)日：2007-04-26

申请号：PCT/US2006/041163

申请日：2006-10-19

Applicant: THERUS CORPORATION ,  SILVERSTEIN, Fred ,  EMERY, Charles ,  KOOK, John ,  PEDERSON, Robert ,  SEKINS, K. Michael ,  ZHAO, Xiao ,  KULESA, Larry ,  LAHMAN, Robyn ,  AUGUSTINE, Larry ,  PEROZEK, David, M. ,  ZHANG, Jimin ,  GISSEL BERG, Margo ,  ANDERSON, Thomas

Inventor： EMERY, Charles ,  KOOK, John ,  PEDERSON, Robert ,  SEKINS, K. Michael ,  ZHAO, Xiao ,  KULESA, Larry ,  LAHMAN, Robyn ,  AUGUSTINE, Larry ,  PEROZEK, David, M. ,  ZHANG, Jimin ,  GISSEL BERG, Margo ,  ANDERSON, Thomas

IPC: A61B17/00 ,  A61M25/10 ,  A61N7/02 ,  A61B19/00

CPC classification number: A61B8/0833 ,  A61B5/026 ,  A61B8/0841 ,  A61B8/12 ,  A61B8/4405 ,  A61B8/445 ,  A61B17/0057 ,  A61B18/02 ,  A61B34/25 ,  A61B50/13 ,  A61B2017/00557 ,  A61B2017/00637 ,  A61B2017/00641 ,  A61B2090/372 ,  A61B2090/3784 ,  A61B2090/3929 ,  A61B2090/3958 ,  A61B2090/397 ,  A61F2/82 ,  A61M25/10 ,  A61N7/02

Abstract: Systems and methods for sealing a vascular opening such as an arteriotomy formed during a femoral artery catheterization procedure are described. Included are methods for locating the arteriotomy, aligning the therapeutic applicator to the arteriotomy, transiently occluding the blood vessel, and a station keeping procedure for maintaining alignment. Locating the arteriotomy and aligning the applicator may be performed using a targeting catheter having one or more targeting aids, such as an inflatable balloon or sensor (e.g., Doppler or temperature sensor), and an ultrasonic beacon. Station keeping may be performed using overlapping ultrasound signals that are sent to a target tissue site and the echo detected. An algorithm is described for detecting tissue movement relative to the applicator based on comparison of the echo with a previously stored echo.

Abstract translation: 描述了用于密封血管开口的系统和方法，例如在股动脉导管插入术过程中形成的动脉切开术。 包括用于定位动脉切开术的方法，将治疗施用器对准动脉切开术，瞬时闭塞血管，以及用于维持对准的站保持程序。 定位动脉切开术并对准施用器可以使用具有一个或多个靶向辅助物的靶向导管（例如可充气球囊或传感器（例如，多普勒或温度传感器））和超声波信标进行。 可以使用发送到目标组织部位并检测到回波的重叠超声信号来执行站保持。 描述了一种用于基于回波与先前存储的回波的比较来检测相对于施用器的组织运动的算法。

公开(公告)号：WO2006019804A2

公开(公告)日：2006-02-23

申请号：PCT/US2005/024830

申请日：2005-07-13

Applicant: WYETH ,  YAN, Gouying ,  XIE, Yuhong ,  PAULSEN, Janet, E. ,  ZHANG, Jimin ,  ROOKEY, Dionna ,  BATES, Brian ,  LU, Zhijian ,  MARK, Robert ,  CAMPOS, Susie, J.

Inventor： YAN, Gouying ,  XIE, Yuhong ,  PAULSEN, Janet, E. ,  ZHANG, Jimin ,  ROOKEY, Dionna ,  BATES, Brian ,  LU, Zhijian ,  MARK, Robert ,  CAMPOS, Susie, J.

CPC classification number: C07K14/70503 ,  C07K14/4713 ,  C07K2319/21

Abstract: The present invention provides compositions and methods useful for purifying recombinant myelin-associated glycoprotein (MAG) and fragments thereof. In particular, the invention provides a one-step purification method for MAG and MAG fragments. Novel forms of human recombinant MAG protein are also disclosed in addition to methods of reliably producing and storing stable recombinant MAG proteins.

Abstract translation: 本发明提供了用于纯化重组髓磷脂相关糖蛋白（MAG）及其片段的组合物和方法。 特别地，本发明提供了用于MAG和MAG片段的一步纯化方法。 除了稳定产生和储存稳定的重组MAG蛋白的方法外，还公开了新的人重组MAG蛋白形式。

公开(公告)号：WO2016164731A3

公开(公告)日：2016-10-13

申请号：PCT/US2016/026655

申请日：2016-04-08

Applicant: NOVARTIS AG ,  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  BITTER, Hans ,  BORDEAUX, Jennifer, Mary ,  BRANNETTI, Barbara ,  BROGDON, Jennifer ,  DAKAPPAGARI, Naveen, Kumar ,  GILL, Saar ,  HIGHFILL, Steven ,  HUANG, Lu ,  JUNE, Carl, H. ,  KIM, Ju, Young ,  LEI, Ming ,  LI, Na ,  LOWE, Andreas ,  ORLANDO, Elena ,  RUELLA, Marco ,  TRAN, Thai ,  ZHANG, Jimin ,  ZHOU, Li

Inventor： BITTER, Hans ,  BORDEAUX, Jennifer, Mary ,  BRANNETTI, Barbara ,  BROGDON, Jennifer ,  DAKAPPAGARI, Naveen, Kumar ,  GILL, Saar ,  HIGHFILL, Steven ,  HUANG, Lu ,  JUNE, Carl, H. ,  KIM, Ju, Young ,  LEI, Ming ,  LI, Na ,  LOWE, Andreas ,  ORLANDO, Elena ,  RUELLA, Marco ,  TRAN, Thai ,  ZHANG, Jimin ,  ZHOU, Li

IPC: C07K14/725 ,  C07K16/28 ,  C12N5/0783 ,  A61K39/00

Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with one or more B-cell inhibitors, e.g., inhibitors of one or more of CD1O, CD20, CD22, CD34, CD123, FLT-3, ROR1, CD79b, CD179b, or CD79a. The disclosure additionally features novel antigen binding domains and CAR molecules directed to CD20 and CD22, and uses, e.g., as monotherapies or in combination therapies. The invention also provides kits and compositions described herein.

Abstract translation: 本发明提供了用于治疗与CD19表达相关的疾病的组合物和方法，例如通过给予包含本文所述的CD19CAR的重组T细胞与一种或多种B细胞抑制剂的组合， 例如CD10，CD20，CD22，CD34，CD123，FLT-3，ROR1，CD79b，CD179b或CD79a中的一种或多种的抑制剂。 本公开还特征在于新颖的抗原结合结构域和针对CD20和CD22的CAR分子，并且例如用作单一疗法或组合疗法。 本发明还提供了本文所述的试剂盒和组合物。