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    METHODS AND DEVICES FOR ORTHOVOLTAGE OCULAR RADIOTHERAPY AND TREATMENT PLANNING
    1.
    发明申请
    METHODS AND DEVICES FOR ORTHOVOLTAGE OCULAR RADIOTHERAPY AND TREATMENT PLANNING 审中-公开
    OROLOVOLTAGE OCULAR放射治疗与治疗计划的方法和装置

    公开(公告)号：WO2009075714A1

    公开(公告)日：2009-06-18

    申请号：PCT/US2008/012341

    申请日：2008-10-31

    Applicant: ORAYA THERAPEUTICS, INC. ,  GERTNER, Michael ,  ARNOLDUSSEN, Mark ,  CHELL, Erik ,  HANSEN, Steven, D. ,  LIANG, Junzhong

    Inventor： GERTNER, Michael ,  ARNOLDUSSEN, Mark ,  CHELL, Erik ,  HANSEN, Steven, D. ,  LIANG, Junzhong

    IPC: A61N5/10

    CPC classification number: A61N5/1037 ,  A61N5/1017 ,  A61N5/103 ,  A61N5/1064 ,  A61N2005/1091

    Abstract: A method, code and system for planning the treatment a lesion on or adjacent to the retina of an eye of a patient are disclosed. There is first established at least two beam paths along which x-radiation is to be directed at the retinal lesion. Based on the known spectral and intensity characteristics of the beam, a total treatment time for irradiation along each beam paths is determined. From the coordinates of the optic nerve in the aligned eye position, there is determined the extent and duration of eye movement away from the aligned patient-eye position in a direction that moves the patient's optic nerve toward the irradiation beam that will be allowed during treatment, while still maintaining the radiation dose at the patient optic nerve below a predetermined dose level.

    Abstract translation: 公开了一种用于规划治疗患者眼睛或其附近的视网膜上的病变的方法，代码和系统。 首先建立至少两个光束路径，X射线将沿着该路径被引导到视网膜损伤处。 基于光束的已知光谱和强度特性，确定沿着每个光束路径的照射的总处理时间。 从对准的眼睛位置的视神经的坐标，确定眼睛移动远离对准的患者眼睛位置的方向的程度和持续时间沿着将患者的视神经移动到将在治疗期间允许的照射束的方向 同时仍然将患者视神经的辐射剂量保持在预定剂量水平以下。

    DEVICE AND ASSEMBLY FOR POSITIONING, STABILIZING AND TREATING AN EYE
    2.
    发明申请
    DEVICE AND ASSEMBLY FOR POSITIONING, STABILIZING AND TREATING AN EYE 审中-公开
    用于定位，稳定和治疗眼睛的装置和装置

    公开(公告)号：WO2008150330A1

    公开(公告)日：2008-12-11

    申请号：PCT/US2008/004999

    申请日：2008-04-17

    Applicant: ORAYA THERAPEUTICS, INC. ,  GERTNER, Michael ,  ARNOLDUSSEN, Mark ,  HERRON, Matt

    Inventor： GERTNER, Michael ,  ARNOLDUSSEN, Mark ,  HERRON, Matt

    IPC: A61B3/00

    CPC classification number: A61F9/008 ,  A61B3/113 ,  A61B3/12 ,  A61B3/152 ,  A61B17/0231 ,  A61F9/00804 ,  A61F9/00808 ,  A61F9/009 ,  A61F2009/00846 ,  A61F2009/00865 ,  A61N5/1017 ,  A61N5/1049 ,  A61N2005/1059 ,  A61N2005/1091

    Abstract: An eye contact device and assembly for stabilizing a human eye at a selected position in an external coordinate system is disclosed. The device includes an eye-contact member having an inner contact surface for contacting a front surface of an eye, and a vacuum port formed within the eye-contact member and communicating with the eye-contact member's contact surfaces, by which a negative pressure can be applied between the eye and the contact surface, to stabilize the position of the eye with respect to the device. The device, which is adapted to be biased against the patient's eye, to secure the device to the eye, may be pivotally coupled to a positioning arm, and may carry one or more beam-directing elements by which the position of the device in an external coordinate system can be determined.

    Abstract translation: 公开了一种用于在外部坐标系中的选定位置处稳定人眼的眼睛接触装置和组件。 该装置包括具有用于接触眼睛前表面的内接触表面的眼睛接触构件和形成在眼睛接触构件内并与眼睛接触构件的接触表面连通的真空端口，负压可以 施加在眼睛和接触表面之间，以稳定眼睛相对于装置的位置。 适于被偏压抵靠患者眼睛的装置将装置固定到眼睛上的装置可以枢转地联接到定位臂，并且可以承载一个或多个光束引导元件，通过该元件将装置的位置 可以确定外部坐标系。

    METHODS AND DEVICES FOR CHRONIC EMBOLIC PROTECTION
    3.
    发明申请
    METHODS AND DEVICES FOR CHRONIC EMBOLIC PROTECTION 审中-公开
    用于慢性栓塞保护的方法和装置

    公开(公告)号：WO2006055052A2

    公开(公告)日：2006-05-26

    申请号：PCT/US2005/025021

    申请日：2005-07-14

    Applicant: GERTNER, Michael

    Inventor： GERTNER, Michael

    IPC: A61M29/00

    CPC classification number: A61F2/01 ,  A61F2002/018 ,  A61F2230/0019 ,  A61F2230/0069 ,  A61F2250/0023

    Abstract: A medical device for interposition between a first flow path and at least one second flow path is provided. The device includes a first surface facing toward the opening of at least one second flow path; and a second surface facing away from the opening of at least one second flow path. When the device is in the operative position, it extends less than the complete circumference of the first flow path and substantially covers the opening of at least one second flow path. The device contains one or more surface features to facilitate chronic implantation. The device further has one or more characteristic porosities. Different configurations are indicated depending on the pathophysiology being treated and dictate the characteristic porosity of the device. In some, cases blood is prevented from reaching the second flow path and in other cases, particulates traveling within the blood are prevented from reaching the second flow path. Methods of preventing emboli or blood flow into the second flow path are also provided. Methods and devices for delivery are also provided.

    Abstract translation: 提供了用于插入第一流路和至少一个第二流路之间的医疗装置。 该装置包括面向至少一个第二流动路径的开口的第一表面; 以及远离至少一个第二流动路径的开口的第二表面。 当设备处于操作位置时，其延伸小于第一流动路径的整个圆周并且基本上覆盖至少一个第二流动路径的开口。 该装置包含一个或多个表面特征以便于慢性植入。 该装置还具有一个或多个特征孔隙率。 根据正在治疗的病理生理学来指示不同的构型，并且决定了器械的特征孔隙度。 在一些情况下，防止血液到达第二流动路径，并且在其他情况下，防止在血液内行进的微粒到达第二流动路径。 还提供了防止栓塞或血液流入第二流路的方法。 还提供了交付方法和设备。

    ORTHOVOLTAGE RADIOSURGERY
    7.
    发明申请
    ORTHOVOLTAGE RADIOSURGERY 审中-公开

    公开(公告)号：WO2008124801A3

    公开(公告)日：2008-12-31

    申请号：PCT/US2008059808

    申请日：2008-04-09

    Applicant: ORAYA THERAPEUTICS INC ,  GERTNER MICHAEL ,  HANSEN STEVEN D

    Inventor： GERTNER MICHAEL ,  HANSEN STEVEN D

    IPC: A61N5/10

    CPC classification number: A61N5/1067 ,  A61B6/506 ,  A61B6/508 ,  A61N5/10 ,  A61N5/1001 ,  A61N5/1017 ,  A61N5/1045 ,  A61N5/1048 ,  A61N5/1049 ,  A61N5/1064 ,  A61N5/1065 ,  A61N5/1077 ,  A61N5/1084 ,  A61N2005/1019 ,  A61N2005/1022 ,  A61N2005/105 ,  A61N2005/1051 ,  A61N2005/1059 ,  A61N2005/1091 ,  A61N2005/1097

    Abstract: A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, the target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, the target tissues inside the global coordinate system lead to direction of an automated positioning system that is directed based on the target tissues within the coordinate system. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial marker is used to identify the location of the target tissues. In some embodiments, an eye is held with force and in alignment with the system. In some embodiments, the device automatically turns off with excessive movement outside of alignment along an axis of the eye. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.

    Abstract translation: 描述了放射外科系统，其被配置为将治疗剂量的辐射递送到患者中的目标结构。 在一些实施方案中，治疗炎症性眼部疾病，特别是黄斑变性。 在一些实施方案中，身体的其它病症或组织用辐射剂量治疗。 在一些实施例中，目标组织基于眼睛成像被放置在全局坐标系中。 在一些实施例中，全局坐标系统内的目标组织导致基于坐标系统内的目标组织定向的自动定位系统的方向。 在一些实施例中，使用治疗计划，其中针对要治疗的特定疾病和/或要避免的结构确定束能量和治疗时间的方向和持续时间。 在一些实施方案中，使用基准标记来鉴定靶组织的位置。 在一些实施例中，眼睛被保持并且与系统对准。 在一些实施例中，设备沿着眼睛的轴线的对准内部的过度运动自动关闭。 在一些实施例中，描述了放射外科手术与其他治疗组合使用的放射治疗疗法，并且可以在其它治疗之前，之前或之后随同伴随地递送。

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