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    SYSTEM AND METHOD FOR EXTRACTING A TARGET MOIETY FROM A SAMPLE USING ACOUSTIC DROPLET EJECTION
    1.
    发明申请
    SYSTEM AND METHOD FOR EXTRACTING A TARGET MOIETY FROM A SAMPLE USING ACOUSTIC DROPLET EJECTION 审中-公开

    公开(公告)号：WO2019173238A1

    公开(公告)日：2019-09-12

    申请号：PCT/US2019/020596

    申请日：2019-03-04

    Applicant: LABCYTE, INC.

    Inventor： OLECHNO, Joseph D. ,  ELLSON, Richard N.

    IPC: C12N15/10 ,  G01N1/40 ,  G01N35/10

    Abstract: A method and system are provided for extracting a target analyte from a sample using acoustic ejection technology. The method involves applying focused acoustic energy to a fluid reservoir housing a fluid composition that contains a target analyte and comprises an upper region and a lower region, where the concentration of the target analyte in the upper region differs from that in the lower region. The focused acoustic energy is applied in a manner that is effective to result in the ejection of a fluid droplet from from the fluid composition into a droplet receiver, wherein the concentration of the analyte in the droplet corresponds to either the concentration of the analyte in the upper region or the concentration of the analyte in the lower region, and wherein the concentration of the analyte is substantially uniform throughout the droplet. The fluid composition may comprise an ionic liquid, used in the extraction of ionic target analytes. Related methods and an acoustic extraction system are also provided.

    METHOD AND SYSTEM FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A FLUID SAMPLE
    4.
    发明申请
    METHOD AND SYSTEM FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN A FLUID SAMPLE 审中-公开
    用于确定流体样品中分析物浓度的方法和系统

    公开(公告)号：WO2016061592A1

    公开(公告)日：2016-04-21

    申请号：PCT/US2015/056288

    申请日：2015-10-19

    Applicant: LABCYTE INC.

    Inventor： ELLSON, Richard N. ,  STEARNS, Richard G. ,  OLECHNO, Joseph D. ,  SINCLAIR, Ian ,  WINGFIELD, Jonathan

    IPC: G01N33/543 ,  C12Q1/68 ,  G01N21/64

    CPC classification number: G01N1/28 ,  C12Q1/68 ,  G01N33/6848 ,  G01N33/6851 ,  H01J49/04 ,  H01J49/0422 ,  H01J49/0431 ,  Y10T436/24 ,  Y10T436/25875

    Abstract: A method and system are provided for detecting the concentration of an anaiyte in a fluid sample. The method and system involve analysis of a volatilized, ionized fluid sample using a mass spectrometer or other ionic anaiyte detection device that provides a signal proportional in intensity to the quantity of ionized anaiyte detected. The improvement involves replacement of a necessary non-analyte component in the fluid sample with a substitute component that serves the same purpose as the original component but is either more volatile than the original component and/or the anaiyte or undergoes a reaction to provide lower molecular weight reaction products, and results in an increased intensity in signal and signal-to-noise ratio. Acoustic fluid ejection is a preferred method of generating nanoliter-sized droplets of fluid sample that are then volatilized, ionized, and analyzed.

    Abstract translation: 提供了一种用于检测流体样品中厌氧剂浓度的方法和系统。 该方法和系统涉及使用质谱仪或其它离子电解质检测装置对挥发的离子化流体样品进行分析，其提供了与所检测的电离量的强度成正比的信号。 该改进涉及用具有与原始组分相同目的的替代组分替换流体样品中必需的非分析物组分，但是比原始组分和/或非离子组分更易挥发或者经历反应以提供较低分子量 重量反应产物，并导致信号和信噪比的强度增加。 声流体喷射是产生流体样品的纳升级大小的液滴的优选方法，然后将其挥发，电离和分析。

    THERMAL ADAPTER FOR AUTOMATED THERMAL CYCLING
    5.
    发明申请
    THERMAL ADAPTER FOR AUTOMATED THERMAL CYCLING 审中-公开

    公开(公告)号：WO2022047327A1

    公开(公告)日：2022-03-03

    申请号：PCT/US2021/048277

    申请日：2021-08-30

    Applicant: LABCYTE INC.

    Inventor： ELLSON, Richard N.

    IPC: B01L3/00

    Abstract: Systems and methods for processing samples in a multi-well reaction vessel can include inserting a multi-well reaction vessel into a heating chamber of a thermal cycler, enclosing the multi-well reaction vessel in the heating chamber, and compressing a bottom surface of the multi-well reaction vessel into a compliant thermally conductive insert to increase a thermal contact area between the bottom surface and the compliant thermally conductive insert. The compliant thermally conductive insert can be placed between the multi-well reaction vessel and a heating element of the thermal cycler, where heat flux from the heating element passes through the compliant thermally conductive insert to the reaction vessel. The compliant thermally conductive insert can include an elastically deformable creped graphite sheet that can reversibly deform according to different compression profiles depending on the topography or flexure of the reaction vessel and/or heating element.

    HIGH-EFFICIENCY TRANSFECTION OF BIOLOGICAL CELLS USING SONOPORATION
    7.
    发明申请
    HIGH-EFFICIENCY TRANSFECTION OF BIOLOGICAL CELLS USING SONOPORATION 审中-公开
    利用SONOPORATION技术高效转化生物细胞

    公开(公告)号：WO2018053350A1

    公开(公告)日：2018-03-22

    申请号：PCT/US2017/051909

    申请日：2017-09-15

    Applicant: LABCYTE INC.

    Inventor： HARDEE, Jennifer M. ,  ELLSON, Richard N. ,  STEARNS, Richard G. ,  HADIMIOGLU, Babur ,  OLECHNO, Joseph D. ,  BLAUWKAMP, Marsha N.

    IPC: C12N15/87

    Abstract: A method is provided for achieving transfection of host cells using sonoporation. An acoustic radiation generator is positioned in acoustic coupling relationship with respect to a reservoir containing host cells to be transfected, exogenous material to be incorporated into the host cells, and a cell-compatible fluid medium. The acoustic radiation generator is activated to generate acoustic radiation and direct the acoustic radiation into the reservoir in a manner effective to enable transfection of the host cells with the exogenous material.

    Abstract translation: 提供了使用声强实现宿主细胞转染的方法。 声辐射发生器相对于含有待转染的宿主细胞，待并入宿主细胞中的外源性物质和细胞相容性流体介质的储库声学耦合关系定位。 激活声辐射发生器以产生声辐射，并以有效使得能够用外源材料转染宿主细胞的方式将声辐射引导到贮存器中。

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