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公开(公告)号：WO2023004356A2
公开(公告)日：2023-01-26
申请号：PCT/US2022/073954
申请日：2022-07-20
发明人： HU, Yi-Zhen , EVANS, Brian
IPC分类号： C09B23/08 , C09B1/00 , G01N21/00 , G01N21/64 , C07D201/00 , C07D471/00 , C07D519/00 , C07D471/04 , C09B23/083
摘要： The present disclosure relates to new and useful azaindole cyanine (pyrrolo pyridine cyanine) compounds. Use of the compounds as dyes that operate in the far-red and near-IR spectral region in biological imaging, and methods of making the compounds are also disclosed herein. The azaindole cyanine (pyrrolo pyridine cyanine) compounds have formulas (I) and (II).
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公开(公告)号：WO2018044688A1
公开(公告)日：2018-03-08
申请号：PCT/US2017/048467
申请日：2017-08-24
发明人： YORK, Adam , WELCH, Eric , GEE, Kyle , WANG, Xin , AGGELER, Robert , HU, Yi-Zhen
IPC分类号： C09K11/02 , C09K11/06 , C08G61/10 , C08G61/12 , G01N33/533
摘要： Water-soluble, fluorescent particles and compositions, kits, and methods of making and using such particles are disclosed. Processes for preparing fluorescent particles and for controlling the size, polydispersity and optical properties of such particles also are provided.
摘要翻译： 公开了水溶性荧光颗粒和组合物，试剂盒以及制造和使用这种颗粒的方法。 还提供了制备荧光颗粒和控制这些颗粒的尺寸，多分散性和光学性质的方法。
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3.发明申请DIBENZOSILOLE MONOMERS AND POLYMERS AND METHODS FOR THEIR PREPARATION AND USE 审中-公开二苯并三唑单体和聚合物及其制备和使用方法
公开(公告)号：WO2016073052A1
公开(公告)日：2016-05-12
申请号：PCT/US2015/045351
申请日：2015-08-14
发明人： GEE, Kyle , WANG, Xin , KANG, Hee, Chol , CHEN, Aimei , WU, Yexin , HU, Yi-Zhen , AGGELER, Robert , LOW, Quentin
IPC分类号： C07F7/08 , C08G61/12 , C08L65/00 , G01N33/533 , G01N33/58
CPC分类号： C08G61/123 , C07F7/0816 , C07F7/083 , C08G2261/122 , C08G2261/124 , C08G2261/1424 , C08G2261/145 , C08G2261/1644 , C08G2261/1646 , C08G2261/3142 , C08G2261/3244 , C08G2261/334 , C08G2261/344 , C08G2261/411 , C08G2261/522 , C08G2261/5222 , C08G2261/72 , C08G2261/94 , C08L65/00 , C09K11/06 , C09K2211/1416 , C09K2211/1491 , G01N33/533 , G01N33/545 , G01N33/582 , H01L51/0039 , H01L51/0043 , H01L51/0094
摘要： Water-soluble, conjugated polymers containing one or more dibenzosilole monomer residues, as well as compositions, kits, and methods of making and using such polymers are disclosed. Also disclosed are dibenzosilole derivatives substituted with one or more water-solubilizing groups, and methods of making and using such derivatives to prepare water-soluble dibenzosilole polymers.
摘要翻译： 公开了含有一种或多种二苯并四唑单体残基的水溶性共轭聚合物，以及组合物，试剂盒以及制备和使用这些聚合物的方法。 还公开了被一个或多个水溶性基团取代的二苯并四唑衍生物，以及制备和使用这些衍生物以制备水溶性二苯并四唑聚合物的方法。
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4.发明申请MODIFIED NUCLEIC ACID BINDING CYANINE DYES FOR THE DETECTION OF REACTIVE OXYGEN SPECIES 审中-公开用于检测反应性氧物种的改性核酸结合氰胺染料
公开(公告)号：WO2013148038A1
公开(公告)日：2013-10-03
申请号：PCT/US2013/027805
申请日：2013-02-26
发明人： HU, Yi-Zhen , CHEN, Aimei , KANG, Hee Chol , GEE, Kyle , MANDAVILLI, Bhaskar
IPC分类号： C09B23/02 , C09B23/04 , C09B23/06 , G01N33/533 , G01N33/58
摘要： Disclosed herein are compounds, compositions, methods, and kits for detecting reactive oxygen species (ROS) by conventional fluorescence microscopy, fluorescence spectroscopy, flow cytometry, and/or high content imaging. The compounds disclosed herein are novel reduced nucleic acid binding cyanine dyes, which dyes are probes for detecting ROS and measuring oxidative stress in cells either in vitro and/or in vivo . Also described herein are processes for preparing novel reduced dyes, i.e ., ROS probes, for use in the disclosed compositions, methods and kits.
摘要翻译： 本文公开了通过常规荧光显微镜，荧光光谱，流式细胞术和/或高含量成像检测活性氧（ROS）的化合物，组合物，方法和试剂盒。 本文公开的化合物是新的还原性核酸结合花青染料，其染料是用于检测体内和/或体内细胞中ROS和测量氧化应激的探针。 本文还描述了用于制备用于所公开的组合物，方法和试剂盒的新型还原染料即ROS探针的方法。
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公开(公告)号：WO2010093726A2
公开(公告)日：2010-08-19
申请号：PCT/US2010/023793
申请日：2010-02-10
发明人： HU, Yi-Zhen , KANG, Hee Chol
IPC分类号： C07D403/14 , C07D403/10 , C07D403/06
CPC分类号： C07H19/207 , C07D209/14 , C07D209/26 , C07D401/10 , C07D401/14 , C09B23/0041 , C09B23/0066 , C09B23/086 , C09B23/164 , C09K11/06 , C09K2211/1007 , C09K2211/1014 , C09K2211/1022 , C09K2211/1044 , C09K2211/1059 , C09K2211/1074 , G01N33/52
摘要： Provided herein are heptamethine cyanine dyes having a large Stokes shift, and the salts and conjugates thereof. Also provided are methods of using and making such large Stokes shift dyes as fluorescence resonance energy transfer (FRET) acceptors or donors.
摘要翻译： 本文提供具有大的斯托克斯位移的七甲基氰花青染料及其盐和共轭物。 还提供了使用和制备这种大的斯托克斯位移染料作为荧光共振能量转移（FRET）受体或供体的方法。
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公开(公告)号：WO2020033681A3
公开(公告)日：2020-02-13
申请号：PCT/US2019/045697
申请日：2019-08-08
发明人： YANG, Jongtae , WANG, Xin , HU, Yi-Zhen , GEE, Kyle , CHEN, Aimei , BENSON, Scott , EVANS, Brian , RUKAVISHNIKOV, Aleksey
IPC分类号： C09B69/00 , C09B11/14 , G01N33/58 , C12Q1/6869
摘要： Silicon-substituted rhodamine compounds are disclosed herein. Also described herein are Si R dyes comprising at least one vinyl groupattached to the Si atom (10 position) of the SiR dye. Derivatives, functionalized versions, conjugates, kits, related synthetic methods and uses of Si R compounds also are provided. Silicon-rhodamine (SiR) dyes can provide bright fluorescence at far red wavelengths and exhibit good photostability. The compounds described herein can be useful for fluorescent labeling and detection of biological samples. The compounds have the general structure (I) below.
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公开(公告)号：WO2020033681A2
公开(公告)日：2020-02-13
申请号：PCT/US2019/045697
申请日：2019-08-08
发明人： YANG, Jongtae , WANG, Xin , HU, Yi-Zhen , GEE, Kyle , CHEN, Aimei , BENSON, Scott , EVANS, Brian , RUKAVISHNIKOV, Aleksey
IPC分类号： C09B69/00 , C09B11/14 , G01N33/58 , C12Q1/6869
摘要： Silicon-substituted rhodamine compounds are disclosed herein. Also described herein are SiR dyes comprising at least one vinyl group attached to the Si atom (10 position) of the SiR dye. Derivatives, functionalized versions, conjugates, kits, related synthetic methods and uses of SiR compounds also are provided. Silicon-rhodamine (SiR) dyes can provide bright fluorescence at far red wavelengths and exhibit good photostability. The compounds described herein can be useful for fluorescent labeling and detection of biological samples.
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