公开(公告)号：WO2023281126A2

公开(公告)日：2023-01-12

申请号：PCT/EP2022/079850

申请日：2022-10-26

Applicant: MERCK PATENT GMBH

Inventor： MONTENEGRO, Elvira ,  ENGELHART, Jens ,  KIM, You-Hyun

IPC: C07D201/00

Abstract: Die vorliegende Anmeldung betrifft eine Verbindung einer Formel (I), die Verwendung der Verbindung in elektronischen Vorrichtungen, Verfahren zur Herstellung der Verbindung, und elektronische Vorrichtungen enthaltend die Verbindung.

公开(公告)号：WO2022079067A1

公开(公告)日：2022-04-21

申请号：PCT/EP2021/078239

申请日：2021-10-13

Applicant: MERCK PATENT GMBH

Inventor： STOESSEL, Philipp

IPC: C09K11/00 ,  H01L51/50 ,  C07F5/02 ,  C07D201/00 ,  C07F7/08 ,  C07F9/6584

Abstract: Die vorliegende Erfindung betrifft cyclische Verbindungen, die sich für die Verwendung in elektronischen Vorrichtungen eignen, sowie elektronische Vorrichtungen, insbesondere organischen Elektrolumineszenzvorrichtungen, enthaltend diese Verbindungen.

公开(公告)号：WO2022020547A1

公开(公告)日：2022-01-27

申请号：PCT/US2021/042695

申请日：2021-07-22

Applicant: FMC CORPORATION ,  FMC AGRO SINGAPORE PTE. LTD.

Inventor： SONDERGAARD, Kare ,  VINTHER, Jack, K.

IPC: A01N43/56 ,  A01P7/00 ,  C07D201/00 ,  C07D401/04 ,  C07D231/14

Abstract: An improved method is disclosed for preparing an organic pesticide of Formula 4-A from (1) a composition comprising: (a) a crystalline organic pesticide; (b and c) compounds of Formulae 1 and 2; (d) an amine base and (e) an aprotic solvent; (2) reacting with a sulfonyl chloride of Formula 3; and (3) allowing the mixture to proceed to an organic pesticide of Formula 4-A. wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the disclosure.

公开(公告)号：WO2021024256A1

公开(公告)日：2021-02-11

申请号：PCT/IL2020/050857

申请日：2020-08-05

Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD

Inventor： GIBSON, Dan ,  SARKAR, Amrita

IPC: A61K47/54 ,  A61K47/55 ,  C07D201/00

Abstract: The invention generally concerns a method for conjugating an active material to a Pt complex.

公开(公告)号：WO2020185482A1

公开(公告)日：2020-09-17

申请号：PCT/US2020/021073

申请日：2020-03-05

Applicant: EASTMAN CHEMICAL COMPANY

Inventor： BARNICKI, Scott, Donald ,  HEMBRE, Robert, Thomas ,  CHAKRABORTY, Sumit ,  LANINGHAM, Michael, Richard ,  OSBORNE, Vickie, Hagood ,  DEPEW, Leslie, Sharon ,  STEVENS, Annette, Elizabeth ,  WOOLLINS, John, Derek ,  HUA, Guoxiong

IPC: C01B17/06 ,  C01B7/09 ,  C01B17/24 ,  C07D201/00 ,  C07D341/00 ,  C08K3/00 ,  C08K9/00 ,  C25B1/24

Abstract: Method for producing molecular halogen are disclosed, that include the steps of: oxidizing a halide to produce a mixture comprising one or more of a molecular halogen, a trihalide, and a halide; reducing a polysulfide comprising a higher rank polysulfide dianion to produce a lower rank polysulfide dianion; and recovering molecular halogen from the mixture comprising one or more of a molecular halogen, a trihalide, and a halide.

公开(公告)号：WO2004052850A3

公开(公告)日：2006-03-02

申请号：PCT/US0338558

申请日：2003-12-04

Applicant: SQUIBB BRISTOL MYERS CO ,  VU TRUC CHI ,  BRZOZOWSKI DAVID B ,  FOX RITA ,  GODFREY JOLLIE DUAINE JR ,  HANSON RONALD L ,  KOLOTUCHIN SERGEI V ,  MAZZULLO JOHN A JR ,  PATEL RAMESH N ,  WANG JIANJI ,  WONG KWOK ,  YU JURONG ,  ZHU JASON ,  MAGNIN DAVID R ,  AUGERI DAVID J ,  HAMANN LAWRENCE G

Inventor： VU TRUC CHI ,  BRZOZOWSKI DAVID B ,  FOX RITA ,  GODFREY JOLLIE DUAINE JR ,  HANSON RONALD L ,  KOLOTUCHIN SERGEI V ,  MAZZULLO JOHN A JR ,  PATEL RAMESH N ,  WANG JIANJI ,  WONG KWOK ,  YU JURONG ,  ZHU JASON ,  MAGNIN DAVID R ,  AUGERI DAVID J ,  HAMANN LAWRENCE G

IPC: A61K31/403 ,  A61K31/435 ,  C07C62/06 ,  C07C69/00 ,  C07C69/716 ,  C07C229/28 ,  C07C271/22 ,  C07D20060101 ,  C07D201/00 ,  C07D207/22 ,  C07D207/277 ,  C07D209/02 ,  C07D209/52 ,  C07D221/02

CPC classification number: C07C69/757 ,  C07C62/06 ,  C07C69/635 ,  C07C69/675 ,  C07C229/28 ,  C07C271/22 ,  C07C2603/74 ,  C07D207/22 ,  C07D209/52

Abstract: Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.

Abstract translation: 提供了用于制备二肽基肽酶IV的环丙基稠合吡咯烷基抑制剂的方法和化合物。

公开(公告)号：WO2004074247A3

公开(公告)日：2005-06-02

申请号：PCT/US2004004627

申请日：2004-02-17

Applicant: ENDACEA INC ,  WILSON CONSTANCE N ,  PARTRIDGE JOHN J

Inventor： WILSON CONSTANCE N ,  PARTRIDGE JOHN J

IPC: A61K31/522 ,  A61K31/5377 ,  A61K31/541 ,  C07D20060101 ,  C07D201/00 ,  C07D473/04

CPC classification number: C07D473/04

Abstract: Compounds of the general formula (I) are described wherein A is a 5- or 6-membered aromatic or heteroaromatic ring. Compositions comprising such compounds and methods of use thereof are also described.

Abstract translation: 描述通式（I）的化合物，其中A是5-或6-元芳族或杂芳族环。 还描述了包含这些化合物的组合物及其使用方法。

公开(公告)号：WO01091715A3

公开(公告)日：2002-07-04

申请号：PCT/EP2001/006281

申请日：2001-06-01

IPC: A61K8/00 ,  A61K8/19 ,  A61K8/23 ,  A61K8/30 ,  A61K8/33 ,  A61K8/34 ,  A61K8/35 ,  A61K8/36 ,  A61K8/362 ,  A61K8/365 ,  A61K8/368 ,  A61K8/40 ,  A61K8/41 ,  A61K8/42 ,  A61K8/44 ,  A61K8/46 ,  A61K8/49 ,  A61K8/60 ,  A61K8/64 ,  A61K8/67 ,  A61K8/68 ,  A61K8/72 ,  A61K8/73 ,  A61K8/86 ,  A61K8/96 ,  A61K8/97 ,  A61K8/98 ,  A61K31/198 ,  A61K31/355 ,  A61K31/375 ,  A61K31/70 ,  A61K31/7048 ,  A61K31/715 ,  A61K36/06 ,  A61Q5/00 ,  A61Q19/00 ,  A61Q19/02 ,  C07D201/00 ,  A61K7/48

CPC classification number: A61Q19/02 ,  A61K8/0208 ,  A61K8/19 ,  A61K8/347 ,  A61K8/35 ,  A61K8/362 ,  A61K8/365 ,  A61K8/368 ,  A61K8/41 ,  A61K8/44 ,  A61K8/466 ,  A61K8/4926 ,  A61K8/494 ,  A61K8/4946 ,  A61K8/498 ,  A61K8/4986 ,  A61K8/60 ,  A61K8/602 ,  A61K8/64 ,  A61K8/671 ,  A61K8/673 ,  A61K8/676 ,  A61K8/678 ,  A61K8/68 ,  A61K8/735 ,  A61K8/736 ,  A61K8/86 ,  A61K8/97 ,  A61K8/9706 ,  A61K8/982 ,  A61K36/06 ,  A61K36/23 ,  A61K36/258 ,  A61K36/484 ,  A61K36/515 ,  A61Q19/00 ,  A61K2300/00

Abstract: The objective of the present invention was to enhance the skin whitening effects and blackening prevention effects and supply safe and stable topical agents for dermatological use. For that purpose 4-Hydroxyphenyl- alpha -D-glucopyranoside was combined with auxiliary agents such as ascorbic acid and its derivatives, crude drugs and its extracts, hydroxycarboxylic acid and its salts, oil soluble glycyrrhiza extract, gentian extract, phenol derivatives and their salts, placenta extract, kojic acid and its derivatives, glucosamine and its derivatives, azelaic acid and its derivatives, retinol and its derivatives, pyridoxin and its derivatives, tocopherol and its derivatives, chitosan and its decomposition products, caffeic acid derivatives, hydroxycinnamate and its derivatives, Umbelliferae plant extracts, mycelial cultures and their extracts, plant leaves and their extracts.

Abstract translation: 本发明的目的是增强皮肤美白效果和防止黑化作用，并提供用于皮肤病学用途的安全和稳定的外用剂。 为此，将4-羟基苯基-α-D-吡喃葡萄糖苷与助剂如抗坏血酸及其衍生物，生药及其提取物，羟基羧酸及其盐，油溶性甘草提取物，龙胆提取物，苯酚衍生物及其盐 ，胎盘提取物，曲酸及其衍生物，葡糖胺及其衍生物，壬二酸及其衍生物，视黄醇及其衍生物，吡哆酮及其衍生物，生育酚及其衍生物，壳聚糖及其分解产物，咖啡酸衍生物，羟基肉桂酸酯及其衍生物 ，伞形植物提取物，菌丝体培养物及其提取物，植物叶及其提取物。

公开(公告)号：WO9940068A2

公开(公告)日：1999-08-12

申请号：PCT/EP9900855

申请日：1999-02-05

Applicant: DUPHAR INT RES ,  HARTOG JACOBUS A J ,  VISSER GERBEN M ,  STEEN BARTHOLOMEUS J VAN ,  TULP MARTINUS T M ,  RONKEN ERIC ,  KRUSE CORNELIS G

Inventor： DEN HARTOG JACOBUS A J ,  VISSER GERBEN M ,  VAN STEEN BARTHOLOMEUS J ,  TULP MARTINUS T M ,  RONKEN ERIC ,  KRUSE CORNELIS G

IPC: A61K31/4709 ,  A61K31/496 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D201/00 ,  C07D215/38 ,  C07D401/12 ,  C07D405/12 ,  C07D

CPC classification number: C07D215/38 ,  C07D401/12 ,  C07D405/12

Abstract: The present invention relates to a group of novel 2-aminoquinoline derivatives which are potent and selective agonists of the dopamine D4-receptor. The compounds have general formula (I) wherein (R1)n represents 1 or 2 substituents, which can be the same or different, from the group C1-3-alkyl or alkoxy, halogen, trifluoromethyl, nitro, amino, and mono- or dialkyl (C1-2)-amino, or two groups R1 at adjacent carbon atoms together with the benzene ring may form the benzdioxane group or benzofuran group, X represents nitrogen or carbon, and the dotted line may represent a double bond, (R2)p represents 0, 1 or 2 substituents, which can be the same or different, from the group methyl and ethyl, or (R2)p is a methylene bridge or ethylene bridge, R3 is hydrogen or methyl, and (R)m represents 0, 1, or 2 substituents, which can be the same or different and can be located at all available positions of the quinolyl group, from the group C1-3-alkyl or alkoxy, halogen, trifluoromethyl, nitro, amino, and mono- or dialkyl (C1-2)-amino, on the understanding that R1 cannot represent o-OCH3 when X is nitrogen, (R2)p and R3 are hydrogen, m is 0 and n is 1.

Abstract translation: 本发明涉及一组新的2-氨基喹啉衍生物，其是多巴胺D4-受体的有效和选择性激动剂。 化合物具有通式（I），其中（R1）n表示1或2个可以相同或不同的取代基，可以是C1-3 - 烷基或烷氧基，卤素，三氟甲基，硝基，氨基和单 - 或 二烷基（C1-2） - 氨基或两个相邻碳原子的R1与苯环一起形成苯并二恶烷基或苯并呋喃基，X表示氮或碳，虚线表示双键，（R2） p表示0,1或2个与甲基和乙基基团相同或不同的取代基，或（R2）p是亚甲基桥或乙烯桥，R3是氢或甲基，（R）m表示0 ，1或2个取代基，其可以相同或不同，并且可以位于喹啉基的所有可用位置，C 1-3 - 烷基或烷氧基，卤素，三氟甲基，硝基，氨基和单 - 或 二烷基（C 1-2） - 氨基，但应理解，当X为氮时，R 1不能表示o-OCH 3，（R 2）p和R 3为氢，m为0，n为 是1。

公开(公告)号：WO2022226416A1

公开(公告)日：2022-10-27

申请号：PCT/US2022/026206

申请日：2022-04-25

Applicant: ALIGN TECHNOLOGY, INC.

Inventor： CHOUDHARY, Umesh Upendra ,  SU, Jessica Kalay ,  CHAVEZ, Jennifer Marie ,  COLE, Michael Christopher ,  THAI, Raymond Bao

IPC: C07C69/54 ,  C07C69/86 ,  B33Y70/00 ,  C07F7/02 ,  A61C13/00 ,  C08F220/18 ,  A61K6/887 ,  C07C233/09 ,  B33Y80/00 ,  C07D201/00 ,  C07F7/00 ,  C08F8/12 ,  C08F226/06 ,  C08F293/00 ,  C08F220/30

Abstract: The present disclosure provides photo-polymerizable monomers, photo-curable resins comprising one or more of such monomers, as well as polymeric materials formed from the photo-curable resins. Further provided herein are methods of producing the compositions and using the same for the fabrication of medical devices, such as orthodontic appliances.