公开(公告)号：WO1996031270A1

公开(公告)日：1996-10-10

申请号：PCT/US1996004697

申请日：1996-04-05

Applicant: LXN CORPORATION

Inventor： LXN CORPORATION ,  NEYER, Gebhard

IPC: B01D37/00

CPC classification number: G01N33/5002 ,  B01D39/1623 ,  B01D39/18 ,  B01D69/10 ,  D04H1/435 ,  D04H13/00 ,  G01N33/525 ,  G01N33/526 ,  G01N33/66 ,  Y10T436/25375 ,  Y10T436/255

Abstract: The present invention relates to a method and to a device for separating plasma from whole blood. The method and device utilize a permeable non-glass fiber matrix (4) containing a polyol which is capable of clumping red blood cells. The matrix (4), in the absence of such a polyol, would otherwise be porous to red blood cells. The polyol-containing matrix (4) has a first surface and a second surface such that a whole blood sample which is applied to the first surface flows directionally toward the second surface. Plasma separated from whole blood becomes available at the second surface of the matrix (4) and can be tested for the presence of a particular analyte, such as glucose or fructosamine, as provided by reagent layers, including a buffer layer (6) and an indicator layer (7) in a multilayer test device (1) of the present invention.

Abstract translation: 本发明涉及从全血分离血浆的方法和装置。 该方法和装置利用含有可以聚集红细胞的多元醇的可渗透的非玻璃纤维基质（4）。 在没有这种多元醇的情况下，基质（4）否则对于红细胞是多孔的。 含多元醇的基质（4）具有第一表面和第二表面，使得施加到第一表面的全血样品朝向第二表面方向流动。 从全血分离的血浆在基质（4）的第二表面可用，并且可以测试由试剂层提供的特定分析物如葡萄糖或果糖胺的存在，包括缓冲层（6）和 本发明的多层试验装置（1）中的指示层（7）。

公开(公告)号：WO1996031619A1

公开(公告)日：1996-10-10

申请号：PCT/US1996004703

申请日：1996-04-05

Applicant: LXN CORPORATION

Inventor： LXN CORPORATION ,  GALEN, Robert, S. ,  BURD, John, F. ,  HOBLITZELL, Talei ,  NEYER, Gebhard

IPC: C12Q01/34

CPC classification number: C12Q1/34 ,  C12Q1/54 ,  C12Q2326/12 ,  C12Q2326/14 ,  C12Q2326/92 ,  G01N21/645 ,  G01N33/526 ,  G01N33/66 ,  G01N2333/42 ,  Y10S435/97 ,  Y10S436/828 ,  Y10T436/144444

Abstract: The present invention is directed to a single test system and method for determining the integrated glycemic condition of a subject by measuring the concentration of glucose and the level of protein-bound glucose in a subject's body fluid, such as whole blood. The glucose concentration is indicative of the subject's immediate glycemic condition, whereas the protein-bound glucose concentration is indicative of either intermediate or long-term glycemic condition. Optionally, other analytes indicative of glycemie condition, such as ketone bodies or fatty acid derivatives, can also be measured. The present invention also provides a method of diagnosing diabetes. The invention additionally provides a method for analyzing the concentration of fructosamine in less than or equal to five minutes without the use of a reaction accelerator.

Abstract translation: 本发明涉及用于通过测量受试者体液（例如全血）中葡萄糖浓度和蛋白质结合葡萄糖水平来测定受试者的综合血糖状况的单一测试系统和方法。 葡萄糖浓度表示受试者的立即血糖状况，而蛋白质结合的葡萄糖浓度则指示中度或长期血糖状态。 任选地，还可以测量指示甘氨酸状态的其它分析物，例如酮体或脂肪酸衍生物。 本发明还提供了诊断糖尿病的方法。 本发明另外提供了一种在不使用反应促进剂的情况下分析小于或等于五分钟的果糖胺浓度的方法。

公开(公告)号：WO1997014965A1

公开(公告)日：1997-04-24

申请号：PCT/US1996016451

申请日：1996-10-16

Applicant: LXN CORPORATION

Inventor： LXN CORPORATION ,  BURD, John, F. ,  NEYER, Gebhard

IPC: G01N33/553

CPC classification number: G01N33/553 ,  C12Q1/005 ,  Y10S436/806 ,  Y10S436/815 ,  Y10T436/173845 ,  Y10T436/25

Abstract: The present invention relates to a method for electrochemically measuring the concentration of fructosamine, or its high alkalinity eneaminol tautomer in a body fluid sample.

Abstract translation: 本发明涉及一种电化学测量体液样品中果糖胺或其高碱度烯胺互变异构体浓度的方法。

公开(公告)号：WO1996000897A1

公开(公告)日：1996-01-11

申请号：PCT/US1995008029

申请日：1995-06-23

Applicant: LXN CORPORATION

Inventor： LXN CORPORATION ,  BURD, John, F. ,  HOBLITZELL, Talei ,  NEYER, Gebhard

IPC: G01N33/00

CPC classification number: G01N33/526 ,  Y10S435/805 ,  Y10S436/825 ,  Y10T436/255

Abstract: The present invention is directed to a multi-layer test device (10) and method for analyzing the concentration of fructosamine in a liquid sample. The multi-layer test device (10) has a buffer layer (14) containing a buffer having a pH value of at least 9 which is either superposed above or juxtaposed to an indicator layer (15) containing an indicator capable of being reduced by fructosamine. Supporting the buffer layer (14), the indicator layer (15), and any additional layers in the multi-layer device (10) is at least one support member (16) which optionally has a detection aperture (13) for analyzing the concentration of fructosamine on the indicator layer.

Abstract translation: 本发明涉及一种用于分析液体样品中果糖胺浓度的多层测试装置（10）和方法。 所述多层测试装置（10）具有缓冲层（14），该缓冲层含有pH值至少为9的缓冲液，所述缓冲液叠加在指示剂层（15）上方或并置，所述指示剂层（15）含有能够被果糖胺还原的指示剂 。 支撑缓冲层（14），指示层（15）和多层装置（10）中的任何附加层是至少一个支撑构件（16），其可选地具有用于分析浓度的检测孔（13） 果糖胺在指示剂层上。