公开(公告)号：WO02102455A8

公开(公告)日：2004-05-21

申请号：PCT/US0217852

申请日：2002-06-05

Applicant: MANN ALFRED E FOUND SCIENT RES

Inventor： BYERS CHARLES L ,  FEY KATE E ,  WEISNER RALPH M ,  SCHNITTGRUND GARY D

IPC: A61N1/04 ,  A61N1/05 ,  A61N1/18

CPC classification number: A61N1/0543 ,  A61N1/04

Abstract: An implantable miniature eyelid electrode apparatus (2) that causes a paralyzed eyelid (9) to close or open by passing an electrical stimulating current to a nerve or muscle, is comprised of a longtudinally flexible, nonconductive body containing electrodes that pass an electrical signal to the nearby nerve or muscle, which closes or opens the eyelid.

Abstract translation: 通过将电刺激电流传递到神经或肌肉而导致瘫痪的眼睑（9）闭合或打开的可植入微型眼睑电极装置（2）由包含电信号的电阻器传递到包含电信号 附近的神经或肌肉，其关闭或打开眼睑。

公开(公告)号：WO02102590A8

公开(公告)日：2003-01-23

申请号：PCT/US0218949

申请日：2002-06-12

Applicant: MANN ALFRED E FOUND SCIENT RES

Inventor： FEY KATE E ,  JIANG GUANGQIANG

IPC: B23K35/02 ,  B23K35/30 ,  C04B35/10 ,  C04B35/46 ,  C04B35/48 ,  B32B15/04 ,  B22F3/00 ,  B23K1/19 ,  B23K31/02 ,  B32B9/00 ,  C25D11/02

CPC classification number: C04B37/026 ,  B23K35/0244 ,  B23K35/3033 ,  B23K2203/14 ,  B23K2203/18 ,  B23K2203/52 ,  B32B2311/18 ,  C04B2235/3206 ,  C04B2235/3208 ,  C04B2235/3225 ,  C04B2235/3229 ,  C04B2237/123 ,  C04B2237/343 ,  C04B2237/346 ,  C04B2237/348 ,  C04B2237/403 ,  C04B2237/60 ,  C04B2237/708 ,  Y10T428/1259 ,  Y10T428/265

Abstract: The invention is a method of bonding a ceramic part (6) to a metal part (4) by heating a component assembly (2) comprised of the metal part (4), the ceramic part (6), and a very thin essentially pure interlayer material (8) of a compatible interlayer material (8) placed between the two parts and heated at a temperature that is greater than the temperature of the eutectic formed between the metal part (4) and the metal interlayer material, but that is less than the melting point of either the interlayer material, the ceramic part (6) or the metal part (4). The component assembly (2) is held in intimate contact at temperature in a non-reactive atmosphere for a sufficient time to develop a homogeneous and strong bond between the ceramic part (6) and the metal part (4). The bonded component assembly (2) is optionally treated with acid to remove any residual free nickel and nickel salts, to assure a biocompatible component assembly (2) for implantation in living tissue.

Abstract translation: 本发明是一种通过加热由金属部件（4），陶瓷部件（6）组成的部件组件（2）和非常薄的基本上纯的陶瓷部件（6）而将陶瓷部件（6）接合到金属部件（4） 中间层材料（8）位于两个部分之间并在比金属部件（4）和金属中间层材料之间形成的共晶的温度大的温度下加热，但是较少 比中间层材料，陶瓷部件（6）或金属部件（4）的熔点高。 组件组件（2）在非反应性气氛中的温度下保持紧密接触足够的时间以在陶瓷部件（6）和金属部件（4）之间形成均匀且牢固的结合。 任选地用酸处理粘合组分组件（2）以除去任何残留的游离镍和镍盐，以确保用于植入生物组织的生物相容性组分组件（2）。

公开(公告)号：WO02102452A2

公开(公告)日：2002-12-27

申请号：PCT/US0217353

申请日：2002-05-31

Applicant: MANN ALFRED E FOUND SCIENT RES ,  ADVANCED BIONICS CORP

Inventor： SCHULMAN JOSEPH H ,  FEY KATE E ,  BYERS CHARLES L ,  ZILBERMAN YITZHAK ,  DELL ROBERT D ,  KUZMA JANUSZ

IPC: A61N1/05 ,  A61N1/375 ,  A61N

CPC classification number: A61N1/3752 ,  A61N1/05 ,  A61N1/37205

Abstract: The invention discloses methods of making electrical connections in living tissue between an electrically conductive wire and an implantable miniature device. The device may either stimulate muscles or nerves in the body or detect signals and transmit these signals outside the body or transmit the signals for use at another location within the body. The device is comprised of an electrically insulating or electrically conductive case with at least one electrode for transmitting electrical signals. The electrodes and the wire-electrode connections are protected from the aggressive environment within the body to avoid corrosion of the electrode and to avoid damage to the living tissue surrounding the device.

Abstract translation: 本发明公开了在导电线和可植入微型装置之间的生物组织中进行电连接的方法。 该装置可以刺激身体中的肌肉或神经，或者检测信号并将这些信号传输到身体外部，或者传输信号以在体内的另一位置使用。 该装置由具有至少一个用于传输电信号的电极的电绝缘或导电壳体组成。 电极和线电极连接被保护免受身体内的侵蚀性环境，以避免电极的腐蚀并且避免损坏设备周围的活体组织。