公开(公告)号：WO9209545A3

公开(公告)日：1992-10-29

申请号：PCT/US9108738

申请日：1991-11-21

Applicant: MASSACHUSETTS INST TECHNOLOGY

Inventor： BUCHWALD STEPHEN L ,  KREUTZER KRISTINA A ,  WILLOUGHBY CHRISTOPHER A ,  GROSSMAN ROBERT B ,  BERK SCOTT C ,  SPALTENSTEIN ESTHER ,  GUTIERREZ ALBERTO

IPC: B01J31/16 ,  C07B31/00 ,  C07B41/02 ,  C07B43/04 ,  C07B53/00 ,  C07B61/00 ,  C07C29/136 ,  C07C29/143 ,  C07C29/147 ,  C07C31/02 ,  C07C31/125 ,  C07C209/40 ,  C07C209/42 ,  C07C209/50 ,  C07C209/52 ,  C07C211/17 ,  C07C211/42 ,  C07D207/06 ,  C07D295/02 ,  C07D295/023 ,  C07D307/52 ,  C07C209/30 ,  C07C209/44

CPC classification number: C07D295/023 ,  C07B41/02 ,  C07B43/04 ,  C07B2200/07 ,  C07C29/143 ,  C07C29/147 ,  C07C29/157 ,  C07C209/52 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/06 ,  C07D307/52 ,  C07C31/135 ,  C07C33/22 ,  C07C33/20 ,  C07C31/36 ,  C07C33/03 ,  C07C31/1333 ,  C07C31/125 ,  C07C33/05

Abstract: A process is provided whereby organic carbonyl substrates, including esters, ketones and amides, are reduced in a reaction with a silane reducing reagent and a catalyst. According to the invention esters and ketones can be reduced to alcohols while amides can be reduced to amines, enamines or a mixture thereof. Methods are also provided for catalytically reducing imines to yield amines. Moreover, there is provided a process for the catalytic asymmetric reduction of imines, oximes, hydrazones, and the like, using enantiomerically enriched catalysts, or catalysts in the presence of enantiomerically enriched additives, to provide chiral amine reaction products which are enriched in one enantiomer. Furthermore, there is provided a process for the catalytic asymmetric reduction of ketones, using catalysts in the presence of enantiomerically enriched additives to provide chiral alcohol reaction products which are enriched in one enantiomer.