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公开(公告)号：WO2020068920A8
公开(公告)日：2020-04-02
申请号：PCT/US2019/052868
申请日：2019-09-25
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： BHATIA, Sangeeta, N. , KIRKPATRICK, Jesse , DUDANI, Jaideep, S. , BUSS, Colin , WARREN, Andrew, David
Abstract: Aspects of the present disclosure relate to methods and compositions useful for in vivo and/or in vitro profiling of proteases present in the lung. In some embodiments, the disclosure provides methods of in vivo enzymatic processing of exogenous molecules followed by detection of detectable markers as representative of the presence of active proteases associated with a lung disease, for example, lung cancer and lung infections. In some embodiments, the disclosure provides compositions and methods for production of a lung disease signature and diagnosis of lung disease.
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公开(公告)号：WO2020068920A2
公开(公告)日：2020-04-02
申请号：PCT/US2019/052868
申请日：2019-09-25
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： BHATIA, Sangeeta, N. , KIRKPATRICK, Jesse , DUDANI, Jaideep, S. , BUSS, Colin , WARREN, Andrew, David
Abstract: Aspects of the present disclosure relate to methods and compositions useful for in vivo and/or in vitro profiling of proteases present in the lung. In some embodiments, the disclosure provides methods of in vivo enzymatic processing of exogenous molecules followed by detection of detectable markers as representative of the presence of active proteases associated with a lung disease, for example, lung cancer and lung infections. In some embodiments, the disclosure provides compositions and methods for production of a lung disease signature and diagnosis of lung disease.
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Patent Agency Ranking
公开(公告)号：WO2020068920A3
公开(公告)日：2020-04-02
申请号：PCT/US2019/052868
申请日：2019-09-25
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： BHATIA, Sangeeta, N. , KIRKPATRICK, Jesse , DUDANI, Jaideep, S. , BUSS, Colin , WARREN, Andrew, David
Abstract: Aspects of the present disclosure relate to methods and compositions useful for in vivo and/or in vitro profiling of proteases present in the lung. In some embodiments, the disclosure provides methods of in vivo enzymatic processing of exogenous molecules followed by detection of detectable markers as representative of the presence of active proteases associated with a lung disease, for example, lung cancer and lung infections. In some embodiments, the disclosure provides compositions and methods for production of a lung disease signature and diagnosis of lung disease.
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公开(公告)号：WO2018187688A1
公开(公告)日：2018-10-11
申请号：PCT/US2018/026458
申请日：2018-04-06
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： BHATIA, Sangeeta, N. , DUDANI, Jaideep, S. , KWON, Ester, J. , WARREN, Andrew, David
IPC: C12Q1/37 , A61K49/00 , C07K19/00 , G01N33/542 , G01N33/58
Abstract: Aspects of the disclosure relate to methods and compositions useful for in vivo and/or in vitro enzyme profiling. In some embodiments, the disclosure provides methods of in vivo enzymatic processing of exogenous molecules followed by detection of signature molecules as representative of the presence of active enzymes associated with diseases or conditions. In some embodiments, the disclosure provides compositions and in vitro methods for localization of enzymatic activity in a tissue sample.
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公开(公告)号：WO2019075292A1
公开(公告)日：2019-04-18
申请号：PCT/US2018/055557
申请日：2018-10-12
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： DUDANI, Jaideep, S. , BHATIA, Sangeeta, N.
IPC: G01N33/543 , G01N33/58
CPC classification number: G01N27/3278 , C12Q1/005 , G01N33/54353 , G01N33/5438 , G01N33/57434 , G01N33/582
Abstract: In some aspects, the disclosure relates to compositions and method for detection, classification, and treatment of prostate cancer. In some embodiments, the disclosure relates to prostate protease nanosensors comprising a scaffold linked to a prostate-specific substrate that include a detectable marker capable of being released from the prostate protease nanosensor when exposed to an enzyme present in a prostate. In some embodiments, the disclosure relates to methods of classifying prostate cancer in a subject based upon detection of detectable markers in a sample obtained from a subject who has been administered prostate protease nanosensors.
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6.发明申请
公开(公告)号：WO2017193070A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/031401
申请日：2017-05-05
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： BHATIA, Sangeeta, N. , KWONG, Gabriel, A. , JAIN, Piyush, K. , DUDANI, Jaideep, S. , SCHURLE, Simone
Abstract: The present disclosure relates to methods and products associated with in vitro and in vivo protease activity measurements and enzyme profiling. Some aspects of the present disclosure relate to measuring remotely triggered protease activity. In particular, the disclosure relates to methods of in vivo processing of exogenous molecules followed by detection of signature molecules as representative of the presence or absence of active enzymes associated with disease or conditions. The disclosure also relates to products, kits, and databases for use in the methods of the disclosure.
Abstract translation: 本发明涉及与体外和体内蛋白酶活性测量和酶谱分析相关的方法和产品。 本公开的一些方面涉及测量远程触发的蛋白酶活性。 具体而言，本公开涉及体外处理外源分子的方法，随后检测标记分子以表示存在或不存在与疾病或病症相关的活性酶。 本公开还涉及用于本公开的方法中的产品，试剂盒和数据库。
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公开(公告)号：WO2017177115A1
公开(公告)日：2017-10-12
申请号：PCT/US2017/026564
申请日：2017-04-07
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： BHATIA, Sangeeta, N. , IRVINE, Darrell, J. , WITTRUP, Karl, Dane , WARREN, Andrew, David , DUDANI, Jaideep, S. , MEHTA, Naveen, K.
CPC classification number: G01N33/5088 , B82Y5/00 , C07K7/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K2319/31 , C07K2319/50 , C12Q1/37 , G01N33/574 , G01N2333/96425
Abstract: In some aspects, the disclosure provides compositions and methods for detecting and monitoring the activity of proteases in vivo using affinity assays. The disclosure relates, in part, to the discovery that biomarker nanoparticles targeted to the lymph nodes of a subject are useful for the diagnosis and monitoring of certain medical conditions ( e.g. , metastatic cancer, infection with certain pathogenic agents).
Abstract translation: 在一些方面，本公开内容提供了使用亲和力测定来检测和监测体内蛋白酶活性的组合物和方法。 本公开内容部分涉及发现靶向受试者淋巴结的生物标志物纳米颗粒可用于诊断和监测某些医学病症（例如转移性癌症，用某些病原体感染 ）。
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