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公开(公告)号：WO2017162676A1
公开(公告)日：2017-09-28
申请号：PCT/EP2017/056701
申请日：2017-03-21
摘要： The present invention generally relates to a modified hyaluronic acid (HA) and to a method for making same, more specifically to a (poly)glycerol-modified HA derivative prepared by grafting glycidol to HA. The present invention also relates to the use of the HA derivative for preparing a dermal filler composition, a hydrogel comprising cross-linked HA and the (poly)glycerol-modified HA derivative, and a method for preparing said hydrogel. Furthermore, the present invention relates to the use of the hydrogel as a cosmetic and/or aesthetic product, in particular as a dermal filler for tissue filling, replacing and/or augmenting.
摘要翻译： 本发明一般涉及修饰的透明质酸（HA）及其制备方法，更具体地涉及通过将缩水甘油接枝到HA上制备的（聚）甘油修饰的HA衍生物。 本发明还涉及HA衍生物在制备皮肤填充剂组合物，包含交联的HA和（聚）甘油改性的HA衍生物的水凝胶以及制备所述水凝胶的方法中的用途。 此外，本发明涉及水凝胶作为化妆品和/或美容产品的用途，特别是作为用于组织填充，替代和/或增强的皮肤填充剂。
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公开(公告)号：WO2017001057A1
公开(公告)日：2017-01-05
申请号：PCT/EP2016/001111
申请日：2016-06-29
IPC分类号： A61K47/36 , A61K31/728 , C08L5/08 , C08B37/00 , C08B37/08 , A61K8/73 , A61Q19/00 , A61Q19/08 , A61K8/04
CPC分类号： A61K8/735 , A61K8/042 , A61K31/167 , A61K31/245 , A61K31/728 , A61K2800/10 , A61K2800/594 , A61K2800/805 , A61K2800/91 , A61K2800/95 , A61Q19/00 , A61Q19/08 , C08B37/0072 , C08J3/005 , C08J2305/08 , C08J2405/08 , C08L5/08 , C08L2205/025 , A61K2300/00
摘要： Method of preparing a composition comprising a crosslinked first polymer and a non-crosslinked second polymer, wherein the first and the second polymer are selected from a polysaccharide, and water, wherein the composition contains an anesthetic and/or anti-arrhythmic, comprising at least steps (S2) to (S5): (S2) crosslinking a mixture comprising the first polymer and water; (S3) subsequent to the crosslinking in step (S2), terminating the crosslinking; (S4) subjecting the product obtained after step (S3) to dialysis; (S5) blending the product obtained after step (S4) with a mixture comprising the second polymer and water, wherein the mixture comprises an anesthetic and/or anti-arrhythmic.
摘要翻译： 制备包含交联的第一聚合物和非交联的第二聚合物的组合物的方法，其中所述第一和第二聚合物选自多糖和水，其中所述组合物含有麻醉剂和/或抗心律失常药，至少包含 步骤（S2）至（S5）：（S2）使包含第一聚合物和水的混合物交联; （S3），在步骤（S2）中交联后，终止交联; （S4）使在步骤（S3）后获得的产物透析; （S5）将步骤（S4）后获得的产物与包含第二聚合物和水的混合物混合，其中混合物包含麻醉剂和/或抗心律不齐药。
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3.发明申请
公开(公告)号：WO2018229117A1
公开(公告)日：2018-12-20
申请号：PCT/EP2018/065642
申请日：2018-06-13
发明人： VILLAIN, Franck , WORTMANN, Uwe , KASPERS, Norbert , EGGER, Johannes , REINHOLD, Thomas Sowden , POPP, Guido , KUNZ, Michael , MASON, Jonathan
摘要： The present invention generally relates to a mixing nozzle (12) for mixing at least two liquid compositions such as a first liquid composition and a second liquid composition. The mixing nozzle(10)is configured to be coupled to a body (11) of a multi-component application device(10), in particular to a body (11) of a two- component syringe assembly,for injection of a liquid composition, which body(11)is configured to separately store said at least two solutions. The present invention further relates to a multi-component application device(10)comprising said mixing nozzle (12) and to a kit comprising said mixing nozzle (12) or said application device (10). Furthermore, the present invention relates to a methodusing said application device or said kit, for examplefor replacing or filling a biological tissue or increasing the volume of a biological tissue.
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4.发明申请DERMAL FILLER BASED ON CROSSLINKED HYALURONIC ACID AND CARBOXYMETHYL CELLULOSE LUBRICANT 审中-公开基于交联羟丙酸和羧甲基纤维素润滑剂的真空填料
公开(公告)号：WO2016074794A1
公开(公告)日：2016-05-19
申请号：PCT/EP2015/002270
申请日：2015-11-12
摘要： The present invention relates to injectable dermal filler compositions in the form of a gel, comprising hyaluronic acid (HA), carboxymethyl cellulose (CMC) and, optionally, microparticles such as calcium hydroxyapatite (CaHAP) microparticles. The injectable dermal filler compositions have improved rheological properties while at the same time have low extrusion forces. The present invention further relates to a method for preparing such injectable dermal filler compositions and their use for cosmetic and therapeutic purposes.
摘要翻译： 本发明涉及凝胶形式的可注射皮肤填充剂组合物，其包含透明质酸（HA），羧甲基纤维素（CMC）和任选的微粒如羟基磷灰石（CaHAP）微粒。 可注射的皮肤填充剂组合物具有改善的流变性能，同时具有低的挤出力。 本发明还涉及制备这种可注射的皮肤填充剂组合物的方法及其用于化妆和治疗目的的用途。
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公开(公告)号：WO2015149946A1
公开(公告)日：2015-10-08
申请号：PCT/EP2015/000711
申请日：2015-04-01
发明人： KRAUSE, Andreas , DRABE, Colin , BELKOVI, Lubin , VILLAIN, Franck
IPC分类号： A61Q1/12 , A61Q90/00 , A61K45/06 , A61K8/22 , A61K31/375
CPC分类号： A61K8/22 , A61K8/42 , A61K8/676 , A61K31/07 , A61K31/122 , A61K31/167 , A61K31/355 , A61K31/375 , A61K33/18 , A61K33/20 , A61K33/24 , A61K33/26 , A61K33/30 , A61K33/34 , A61K33/40 , A61K45/06 , A61K2800/91 , A61Q19/08 , A61Q90/00 , A61K2300/00
摘要： The present invention relates to a composition for the in vivo degradation of polysaccharide-containing fillers by radical degradation. The composition of the invention comprising at least one source of oxygen free radicals and at least one catalyst of oxygen free radical generation from the at least one source of oxygen free radicals. The present invention further relates to methods and uses of said composition for filler correction or reversal.
摘要翻译： 本发明涉及一种通过自由基降解体内降解含多糖的填料的组合物。 本发明的组合物包含至少一种氧自由基源和至少一种来自氧自由基的至少一种氧自由基产生的至少一种氧自由基催化剂。 本发明还涉及所述组合物用于填料校正或反转的方法和用途。
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公开(公告)号：WO2015149941A1
公开(公告)日：2015-10-08
申请号：PCT/EP2015/000701
申请日：2015-03-31
IPC分类号： A61L27/20
CPC分类号： A61L27/20 , A61L27/26 , A61L27/50 , A61L27/52 , A61L2400/06 , A61L2430/34 , C08L5/10
摘要： The present invention relates to polysaccharide soft tissue fillers comprising heparosan and processes for their preparation. The polysaccharide soft tissue fillers of the present invention are advantageously used in therapeutic or cosmetic applications such as for the filling of wrinkles.
摘要翻译： 本发明涉及包含heparosan的多糖软组织填充剂及其制备方法。 本发明的多糖软组织填料有利地用于治疗或美容应用，例如用于填充皱纹。
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