公开(公告)号：WO1995024418A1

公开(公告)日：1995-09-14

申请号：PCT/US1995001593

申请日：1995-02-02

Applicant: MINNESOTA MINING AND MANUFACTURING COMPANY

Inventor： MINNESOTA MINING AND MANUFACTURING COMPANY ,  HEILMANN, Steven, M. ,  DRTINA, Gary, J. ,  EITZMAN, Philip, D. ,  HADDAD, Louis, C. ,  HYDE, Frederick, W. ,  JOHNSON, Todd, W. ,  RASMUSSEN, Jerald, K. ,  WILLIAMS, Michael, G.

IPC: C07K01/14

CPC classification number: B01D39/083 ,  B01D15/08 ,  B01D15/361 ,  B01D15/3804 ,  B01D39/086 ,  B01D39/1623 ,  B01D39/18 ,  B01D39/2068 ,  B01D2239/0407 ,  B01D2239/0428 ,  B01D2239/1291 ,  C07K1/34

Abstract: The invention provides a method of separating a biomacromolecule which comprises the steps of providing a separation system including a filter element which comprises a composite filtration medium, said composite filtration medium comprising a filtration layer on the upstream surface of which are located insoluble stationary phase particulates, the particulates being capable of binding to a biomacromolecule or class of biomacromolecules, a reservoir containing a solution mixture comprising at least one biomacromolecule as solute, and a pump and associated tubing to form a closed loop assembly, and recirculation pumping the solution mixture through the filter cartridge so as to bind the at least one biomacromolecule to the stationary phase particulate so as to form a biomacromolecule:stationary phase particulate product. An eluting solution can be pumped through the closed loop assembly which is capable of reversing the biomacromolecule:stationary phase particulate product binding interaction so as to liberate the biomacromolecule.

Abstract translation: 本发明提供了分离生物大分子的方法，其包括提供包括复合过滤介质的过滤元件的分离系统的步骤，所述复合过滤介质在其上游表面上设置有不溶性固定相颗粒的过滤层， 该微粒能够结合生物大分子或一类生物大分子，含有包含至少一种生物大分子作为溶质的溶液混合物的储存器，以及泵和相关管道以形成闭环组件，以及再循环泵送溶液混合物通过过滤器 以便将至少一种生物大分子结合至固定相颗粒，以便形成生物大分子：固定相颗粒产物。 洗脱溶液可以泵送通过闭环组件，其能够逆转生物大分子：固定相颗粒产物结合相互作用以释放生物大分子。

公开(公告)号：WO1996000607A1

公开(公告)日：1996-01-11

申请号：PCT/US1995006118

申请日：1995-05-15

Applicant: MINNESOTA MINING AND MANUFACTURING COMPANY

Inventor： MINNESOTA MINING AND MANUFACTURING COMPANY ,  HAGEN, Donald, F. ,  BAHMET, Wanda ,  HADDAD, Louis, C. ,  PERKINS, Robert, E.

IPC: B01D53/64

CPC classification number: B01J20/28028 ,  B01D15/00 ,  B01D53/64 ,  B01J20/103 ,  B01J20/28059 ,  B01J20/3234 ,  Y10S210/914

Abstract: Composite articles are useful for separating mercury from fluids. The composite articles can be porous supports comprising an inert substrate having immobilized thereon finely divided gold optionally in combination with a tin salt coating. The porous support can be a particulate or porous fibrous web. Alternatively, the composite articles can comprise a porous fibrous membrane having enmeshed therein the aforementioned porous supports which can be in particulate or fibrous forms. The method for separating elemental, ionic, or organic mercury in fluids comprises the steps of contacting and passing a fluid containing mercury through a support comprising a porous, high surface area, inert substrate on which is immobilized finely divided elemental gold at a controlled rate for a time sufficient for the mercury to sorb to the elemental gold and to provide an immobilized gold-mercury amalgam on the support. If a tin salt also is immobilized on the inert substrate, mercury-tin salt can also be formed. In a further, and optional, step, elemental mercury can be removed from the support and optionally can be quantified.

Abstract translation: 复合制品可用于从流体中分离汞。 复合制品可以是多孔载体，其包括其上固定有细碎金的惰性基材，任选与锡盐涂层组合。 多孔载体可以是颗粒或多孔纤维网。 或者，复合制品可以包括多孔纤维膜，其中包含可以是颗粒或纤维形式的上述多孔载体。 用于在流体中分离元素，离子或有机汞的方法包括以下步骤：使含有汞的流体通过包含多孔，高表面积的惰性基质的载体接触并通过，在其上以受控的速率将精细分散的元素金固定在其上 足以使汞吸附到元素金上并在载体上提供固定的金汞汞合金。 如果锡盐也固定在惰性基材上，也可以形成汞锡盐。 在另外的和任选的步骤中，元素汞可以从支持物中除去并且可任选地被定量。

公开(公告)号：WO1995005233A1

公开(公告)日：1995-02-23

申请号：PCT/US1994007053

申请日：1994-06-22

Applicant: MINNESOTA MINING AND MANUFACTURING COMPANY

Inventor： MINNESOTA MINING AND MANUFACTURING COMPANY ,  HEILMANN, Steven, M. ,  DRTINA, Gary, J. ,  EITZMAN, Philip, D. ,  HADDAD, Louis, C. ,  HYDE, Frederick, W. ,  JOHNSON, Todd, W.

IPC: B01D39/14

CPC classification number: B01D39/14 ,  C12N11/02 ,  C12N11/04 ,  C12N11/08

Abstract: Insolubilized enzyme particulates (12) are located on the upstream surface of a filtration layer (11) of a filtering element (30) which can be used in a cartridge filter (40). Employed in a recycling flow reaction system at relatively high flux rates, the cartridges are useful for conducting catalyzed chemical reactions of dissolved solutes, for example esterifications, isomerizations, oxidations, reductions, and cyclizations.

Abstract translation: 不溶解的酶微粒（12）位于可用于筒式过滤器（40）的过滤元件（30）的过滤层（11）的上游表面上。 以相对高的通量速率在循环流动反应系统中使用，所述筒可用于进行溶解的溶质的催化化学反应，例如酯化，异构化，氧化，还原和环化。