公开(公告)号：WO2023091594A1

公开(公告)日：2023-05-25

申请号：PCT/US2022/050293

申请日：2022-11-17

申请人： MOBILION SYSTEMS, INC.

发明人： DEBORD, John Daniel ,  DENG, Liulin ,  BUTTRILL, Jr., Sidney E.

IPC分类号： H01J49/06 ,  G01N27/623 ,  H01J49/02

摘要： A system for separating ions includes first and second surfaces extending along first and second perpendicular directions, an ion channel defined between the surfaces and configured to receive a stream of ions, first and second electrode arrays each including a plurality of electrodes extending in a third direction and respectively associated with the first and second surfaces, means for causing gas to flow across the ion channel in a fourth direction substantially opposite the first direction, and a controller configured to apply a DC voltage gradient to the electrode arrays. The electrode arrays are configured to generate an electric field based on the DC voltage gradient. The electric field and the flow of gas are configured to direct ions having mobilities in a first mobility range along a first path and ions having mobilities in a second mobility range along a second path.

公开(公告)号：WO2023278543A1

公开(公告)日：2023-01-05

申请号：PCT/US2022/035476

申请日：2022-06-29

申请人： MOBILION SYSTEMS, INC.

发明人： KRIOUTCHKOV, Serguei ,  DEBORD, John Daniel ,  DENG, Liulin ,  BUTTRILL, Jr., Sidney E. ,  LEVINE, Myles Elliott ,  ROEHR, Nathan Paul

IPC分类号： H01J49/06 ,  H01J49/00 ,  H01J49/04 ,  G01N27/62 ,  G01N27/622 ,  H01J49/022 ,  H01J49/066

摘要： The present disclosure is directed to an ion funnel and associated systems, where the ion funnel includes a plurality of electrodes each define an opening having an associated inner dimension and receive a RF voltage. The associated inner dimensions progressively reduce in size from approximately a first inner dimension to approximately a second inner dimension. The electrodes define an internal chamber having an outer dimension that reduces at a convergence angle of approximately 30 degrees for at least a majority of a length of the internal chamber from the first inner dimension to the second inner dimension. Additional systems and methods are provided for transferring ions from an ion funnel to an ion mobility device having a pressure greater than that of the ion funnel, for selectively transferring ions from the ion funnel to the ion mobility device, and for stripping ions of certain molecules adducted thereto during transfer.

公开(公告)号：WO2021237101A1

公开(公告)日：2021-11-25

申请号：PCT/US2021/033670

申请日：2021-05-21

申请人： MOBILION SYSTEMS, INC.

发明人： DEBORD, John Daniel ,  DENG, Liulin ,  ANDERSON, Gordon, A.

IPC分类号： G01N27/62

摘要： Methods and apparatus for ion accumulation are disclosed. An apparatus for ion accumulation includes multiple regions. A first region receives and transfers ions to a second region using a first drive potential. The second region is switchable between a first state where it generates a first electric field preventing ions from further movement and entering a third region, and a second state where it generates a second electric field that guides the ions toward the third region. When in the first state, the ions are prevented from further movement by the first electric field, which causes the ions to accumulate in the second region. When in the second state, the ions are moved from the second region to the third region by the second electric field. A method of accumulating ions involves switching an electric field applied to a region between a trap state and a release state.

公开(公告)号：WO2021247820A1

公开(公告)日：2021-12-09

申请号：PCT/US2021/035641

申请日：2021-06-03

申请人： MOBILION SYSTEMS, INC.

发明人： DEBORD, John Daniel ,  DENG, Liulin ,  ROEHR, Nathan Paul

IPC分类号： B01D59/44 ,  G01N27/622 ,  G01N30/72 ,  H01J29/70 ,  H01J49/42 ,  H03K5/156 ,  G01N27/623 ,  H01J49/0031 ,  H01J49/022 ,  H01J49/061 ,  H01J49/062 ,  H01J49/10

摘要： An apparatus for ion manipulation having improved duty cycle includes first and second separation regions separated by a switch that alternates between guiding ions to each of the separation regions. The separation regions separate the ions based on mobility over respective time periods that at least partially overlap. The apparatus can additionally or alternatively include a pre-separation region that filters ions prior to accumulating ions, thus allowing an accumulation region to accumulate for a longer time period. The apparatus can additionally or alternatively include a plurality of gates along the separation region(s) to simultaneously filter a plurality of ion packets sequentially released into the separation region(s). Methods for ion manipulation having improved duty cycle involve separating ions on two separation regions over first and second time periods that at least partially overlap, pre-filtering ions prior to accumulation and separation, and/or simultaneously filtering a plurality of ions packets are also provided.