公开(公告)号：WO2023278543A1

公开(公告)日：2023-01-05

申请号：PCT/US2022/035476

申请日：2022-06-29

Applicant: MOBILION SYSTEMS, INC.

Inventor： KRIOUTCHKOV, Serguei ,  DEBORD, John Daniel ,  DENG, Liulin ,  BUTTRILL, Jr., Sidney E. ,  LEVINE, Myles Elliott ,  ROEHR, Nathan Paul

IPC: H01J49/06 ,  H01J49/00 ,  H01J49/04 ,  G01N27/62 ,  G01N27/622 ,  H01J49/022 ,  H01J49/066

Abstract: The present disclosure is directed to an ion funnel and associated systems, where the ion funnel includes a plurality of electrodes each define an opening having an associated inner dimension and receive a RF voltage. The associated inner dimensions progressively reduce in size from approximately a first inner dimension to approximately a second inner dimension. The electrodes define an internal chamber having an outer dimension that reduces at a convergence angle of approximately 30 degrees for at least a majority of a length of the internal chamber from the first inner dimension to the second inner dimension. Additional systems and methods are provided for transferring ions from an ion funnel to an ion mobility device having a pressure greater than that of the ion funnel, for selectively transferring ions from the ion funnel to the ion mobility device, and for stripping ions of certain molecules adducted thereto during transfer.

公开(公告)号：WO2021247820A1

公开(公告)日：2021-12-09

申请号：PCT/US2021/035641

申请日：2021-06-03

Applicant: MOBILION SYSTEMS, INC.

Inventor： DEBORD, John Daniel ,  DENG, Liulin ,  ROEHR, Nathan Paul

IPC: B01D59/44 ,  G01N27/622 ,  G01N30/72 ,  H01J29/70 ,  H01J49/42 ,  H03K5/156 ,  G01N27/623 ,  H01J49/0031 ,  H01J49/022 ,  H01J49/061 ,  H01J49/062 ,  H01J49/10

Abstract: An apparatus for ion manipulation having improved duty cycle includes first and second separation regions separated by a switch that alternates between guiding ions to each of the separation regions. The separation regions separate the ions based on mobility over respective time periods that at least partially overlap. The apparatus can additionally or alternatively include a pre-separation region that filters ions prior to accumulating ions, thus allowing an accumulation region to accumulate for a longer time period. The apparatus can additionally or alternatively include a plurality of gates along the separation region(s) to simultaneously filter a plurality of ion packets sequentially released into the separation region(s). Methods for ion manipulation having improved duty cycle involve separating ions on two separation regions over first and second time periods that at least partially overlap, pre-filtering ions prior to accumulation and separation, and/or simultaneously filtering a plurality of ions packets are also provided.