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    DIAGNOSTIC AND TREATMENT REGIMEN FOR ACHIEVING BODY WATER HOMEOSTASIS
    3.
    发明申请
    DIAGNOSTIC AND TREATMENT REGIMEN FOR ACHIEVING BODY WATER HOMEOSTASIS 审中-公开

    公开(公告)号：WO2007064871A3

    公开(公告)日：2007-06-07

    申请号：PCT/US2006/045975

    申请日：2006-12-04

    Applicant: MURAD, Howard

    Inventor： MURAD, Howard

    IPC: A61K31/726 ,  A61K31/728 ,  A61K31/685 ,  A61K31/201 ,  A61K31/202 ,  A61K31/195 ,  C07C53/126 ,  C07C229/06 ,  C07F9/10 ,  C07H5/06 ,  C08B37/08

    Abstract: A method for achieving and maintaining an optimized cellular water homeostasis and good connective tissue health in humans, where cellular water homeostasis is expressed as the ratio of intercellular water ("ICW") content to extracellular water ("ECW") content homeostasis comprising the steps of (i) taking a first set of measurements of two or more of ICW, ECW and total body water ("TBW") content; (ii) comparing the first set of measurements against a predetermined set of values associated with a population of people; (iii) administering an initial dosing of a first composition comprising a therapeutically-effective amount of an amino acid/phospholipid pairing ("AAPP"); (iv) taking a follow-up set of measurements of two or more of TBW, ICW and/or ECW after the initial dosing; (v) comparing the follow-up set of measurements against the predetermined set of population values; (vi) administering a follow-up dosing of a follow-up composition comprising a therapeuticaliy-effective amount of an AAPP; (vii) repeating steps (iv) through (vi) until the desired values of TBW, ICW and/or ECW are achieved.

    METHODS OF PROMOTING HAIR GROWTH
    4.
    发明申请
    METHODS OF PROMOTING HAIR GROWTH 审中-公开
    促进头发生长的方法

    公开(公告)号：WO2004087085A1

    公开(公告)日：2004-10-14

    申请号：PCT/US2004/009036

    申请日：2004-03-25

    Applicant: MURAD, Howard

    Inventor： MURAD, Howard

    IPC: A61K7/06

    CPC classification number: A61Q7/00 ,  A61K8/44 ,  A61K8/60 ,  A61K31/198 ,  A61K31/726 ,  A61K33/30 ,  A61K33/32 ,  A61K33/34 ,  A61K2300/00

    Abstract: The present invention relates to methods of promoting hair growth in a patient. The method comprises administering to a patient in need thereof a sugar compound that is converted to a glycosaminoglycan in the patient, a primary antioxidant component, at least one amino acid component, and one or more transition metals.

    Abstract translation: 本发明涉及促进患者头发生长的方法。 该方法包括向有需要的患者施用在患者中转化为糖胺聚糖的糖化合物，主要抗氧化成分，至少一种氨基酸组分和一种或多种过渡金属。

    TOPICAL THERAPEUTIC DELIVERY SYSTEM
    5.
    发明申请
    TOPICAL THERAPEUTIC DELIVERY SYSTEM 审中-公开

    公开(公告)号：WO2007117352A3

    公开(公告)日：2007-10-18

    申请号：PCT/US2007/003427

    申请日：2007-02-08

    Applicant: MURAD, Howard ,  AKYUZ, Rafael

    Inventor： MURAD, Howard ,  AKYUZ, Rafael

    IPC: A61K8/06 ,  A61K8/36

    Abstract: The present invention relates to an oil-in-water emulsion topical delivery system comprising an oil phase; an aqueous phase; phenoxyethanol; an effective exfoliatingamount of a hydrophobic hydroxycarboxylic acid; a non-ionic emulsifier having an HLB of from about 7 to about 10; and at least one skin-supporting ordermatopharmaceutically active agent.

    FRAGRANCED THERAPEUTIC DELIVERY SYSTEM
    6.
    发明申请
    FRAGRANCED THERAPEUTIC DELIVERY SYSTEM 审中-公开
    巧克力治疗系统

    公开(公告)号：WO2007092085A2

    公开(公告)日：2007-08-16

    申请号：PCT/US2006/048383

    申请日：2006-12-20

    Applicant: MURAD, Howard ,  AKYUZ, Rafael

    Inventor： MURAD, Howard ,  AKYUZ, Rafael

    CPC classification number: A61K8/06 ,  A61K8/062 ,  A61K8/22 ,  A61K8/31 ,  A61K8/355 ,  A61K8/361 ,  A61K8/365 ,  A61K8/368 ,  A61K8/44 ,  A61K8/498 ,  A61K8/63 ,  A61K8/64 ,  A61K8/66 ,  A61K8/67 ,  A61K8/671 ,  A61K8/676 ,  A61K8/678 ,  A61K8/68 ,  A61K8/69 ,  A61K8/97 ,  A61K2800/51 ,  A61K2800/782 ,  A61Q7/00 ,  A61Q9/04 ,  A61Q13/00 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/06

    Abstract: The present invention relates to multi-functional topical delivery systems for providing long-lasting delivery of fragrance as. well as skin-supporting and/or pharmaceutically active ingredients comprising (i) an oil phase; (ii) an aqueous phase; (iii) phenoxyethanol at a concentration of from about 2.0% to about 2.7% based on the total weight of the composition; (iv) an effective exfoliating amount of a hydrophobic hydroxycarboxylic acid selected from the group consisting of orthohydroxybenzoic acid, hydroxycarboxylic acids containing a C12 - C24 fatty acid esterified to the alpha carbon hydroxyl group, hydroxycarboxylic acids containing a C12 - C24 fatty alcohol esterified to a carboxyl group; (v) a non-ionic emulsifier having an HLB of from about 7 to about 10; (vi) a fragrance composition; and (vii) at least one skin-supporting or dermatopharmaceutically active agent.

    Abstract translation: 本发明涉及用于提供持久的香味递送的多功能局部递送系统。 以及皮肤支持和/或药物活性成分，其包含（i）油相; （ii）水相; （iii）基于组合物总重量的约2.0％至约2.7％的浓度的苯氧基乙醇; （iv）有效去角质量的选自以下的疏水性羟基羧酸：邻羟基苯甲酸，含有对α碳羟基酯化的C 12 -C 24脂肪酸的羟基羧酸，含有被酯化成C 1 -C 24脂肪醇的C 12 -C 24脂肪醇的羟基羧酸 羧基; （v）HLB为约7至约10的非离子乳化剂; （vi）香料组合物; 和（vii）至少一种皮肤支持或皮肤药物活性剂。

    METHODS FOR TREATING DERMATOLOGICAL AND OTHER HEALTH-RELATED CONDITIONS IN A PATIENT
    7.
    发明申请
    METHODS FOR TREATING DERMATOLOGICAL AND OTHER HEALTH-RELATED CONDITIONS IN A PATIENT 审中-公开
    用于治疗患者的皮肤病和其他与健康有关的病症的方法

    公开(公告)号：WO2005095959A2

    公开(公告)日：2005-10-13

    申请号：PCT/US2005/010343

    申请日：2005-03-28

    Applicant: MURAD, Howard

    Inventor： MURAD, Howard

    IPC: G01N33/50

    CPC classification number: A61Q19/00 ,  A61K8/022 ,  A61K31/198 ,  A61K31/28 ,  A61K2800/92 ,  A61Q5/00 ,  A61Q5/006 ,  A61Q5/12 ,  A61Q19/007 ,  A61Q19/06 ,  A61Q19/08

    Abstract: A method is provided for treating a dermatological condition in a patient. The method includes (a) measuring the intracellular water content of the patient to provide an initial intracellular water content measurement; (b) administering to the patient at least one active agent; (c) re-measuring the intracellular water content of the patient to provide a post-treatment intracellular water content measurement; and (d) repeating steps (b) and (c) until the post-treatment intracellular water content measurement is greater than the initial intracellular water content measurement. A method is also provided for treating other health-related conditions in a patient.

    Abstract translation: 提供了一种治疗患者皮肤病的方法。 该方法包括（a）测量患者的细胞内水含量以提供初始的细胞内含水量测量; （b）向所述患者施用至少一种活性剂; （c）重新测量患者的细胞内水含量以提供后处理细胞内含水量测量; 和（d）重复步骤（b）和（c），直到后处理细胞内含水量测量值大于初始细胞内含水量测量值。 还提供了一种治疗患者其他与健康有关的病症的方法。

    FRAGRANCE DELIVERY SYSTEM
    8.
    发明申请
    FRAGRANCE DELIVERY SYSTEM 审中-公开
    FRAGRANCE交货系统

    公开(公告)号：WO2006080992A1

    公开(公告)日：2006-08-03

    申请号：PCT/US2005/044567

    申请日：2005-12-09

    Applicant: MURAD, Howard

    Inventor： MURAD, Howard

    IPC: A61Q13/00 ,  A61K8/34 ,  A61K8/365 ,  A61K8/368 ,  A61K8/37

    CPC classification number: A61Q13/00 ,  A61K8/34 ,  A61K8/365 ,  A61K8/37

    Abstract: A fragrance delivery systems for use in personal care and personal hygiene articles, such as perfumes and colognes. The fragrance delivery systems includes (i) a fragrant component; a carboxylic acid or a salt or ester thereof, wherein the carboxylic acid selected from the group consisting of an α-hydroxy acid, a β-hydroxy acid, or a polyhydroxy acid; (ii) phenoxyethanol; and (iii) ethanol.

    Abstract translation: 用于个人护理和个人卫生用品（如香水和古龙水）的香味递送系统。 香味递送系统包括（i）芳香成分; 羧酸或其盐或酯，其中选自α-羟基酸，β-羟基酸或多羟基酸的羧酸; （ii）苯氧基乙醇; 和（iii）乙醇。

    METHODS OF MANAGING THE REDNESS ASSOCIATED WITH A DERMATOLOGICAL CONDITION
    9.
    发明申请
    METHODS OF MANAGING THE REDNESS ASSOCIATED WITH A DERMATOLOGICAL CONDITION 审中-公开

    公开(公告)号：WO2006015135A3

    公开(公告)日：2006-02-09

    申请号：PCT/US2005/026816

    申请日：2005-07-29

    Applicant: MURAD, Howard

    Inventor： MURAD, Howard

    IPC: A61K7/00

    Abstract: A method is provided for managing redness of skin associated with a dermatological condition, the method comprising topically administering to the skin of a patient a pharmaceutical composition comprising an extract of goji berries. The pharmaceutical composition used in the methods of the invention can further comprise at least one carboxylic acid.

    PHARMACEUTICAL COMPOSITIONS AND METHODS FOR LOWERING BLOOD PRESSURE AND PULSE RATE
    10.
    发明申请
    PHARMACEUTICAL COMPOSITIONS AND METHODS FOR LOWERING BLOOD PRESSURE AND PULSE RATE 审中-公开
    降低血液压力和脉率的药物组合物和方法

    公开(公告)号：WO2005023272A1

    公开(公告)日：2005-03-17

    申请号：PCT/US2004/024862

    申请日：2004-08-03

    Applicant: MURAD, Howard

    Inventor： MURAD, Howard

    IPC: A61K31/7008

    CPC classification number: A61K31/14 ,  A61K31/198 ,  A61K31/375 ,  A61K2300/00

    Abstract: A pharmaceutical composition comprising (1) a compound that is converted to a glycosaminoglycan in a patient; (2) a primary antioxidant component; (3) at least one amino acid component; and (4) one or more of lecithin, phosphatidyl choline, or choline and methods for lowering blood pressure and/or pulse rate in a patient by administering to the patient the pharmaceutical composition.

    Abstract translation: 一种药物组合物，其包含（1）在患者体内转化为糖胺聚糖的化合物; （2）主要抗氧化成分; （3）至少一个氨基酸成分; 和（4）一种或多种卵磷脂，磷脂酰胆碱或胆碱，以及通过向患者施用药物组合物来降低患者的血压和/或脉搏率的方法。

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