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1.发明申请METHOD FOR SUPPLYING LIGHT BEAMS FOR INTEGRATED CARS AND MULTIPHOTON MICROSCOPY 审中-公开用于集成车和多光子显微镜的光束供应方法
公开(公告)号：WO2011099938A1
公开(公告)日：2011-08-18
申请号：PCT/SG2011/000051
申请日：2011-02-02
Applicant: NATIONAL UNIVERSITY OF SINGAPORE , HUANG, Zhiwei
Inventor： HUANG, Zhiwei
CPC classification number: G01J3/44 , G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/0237 , G01J3/0291 , G01J3/10 , G01N21/6458 , G01N21/65 , G01N2021/653
Abstract: A method and apparatus for supplying light beams for integrated CARS and multiphoton microscopy, and an integrated CARS and multiphoton microscopy system and method. The method for supplying light beams for integrated CARS and multiphoton microscopy comprises the steps of generating a femtosecond pump beam; optionally generating a femtosecond Stokes beam using a portion of the pump beam; spectrally filtering the Stokes beam, the pump beam, or both such that the filtered beams are in a picosecond range or a femtosecond range depending on a desired microscopy operation mode; and supplying the filtered Stokes beam, pump beam, or both to a scanning microscope.
Abstract translation: 一种用于集成CARS和多光子显微镜的光束的提供方法和装置，以及集成CARS和多光子显微镜系统和方法。 用于提供集成CARS和多光子显微镜的光束的方法包括产生飞秒泵浦光束的步骤; 可选地使用泵波束的一部分产生飞秒斯托克斯波束; 对斯托克斯光束，泵浦光束或两者进行光谱滤波，使得滤波光束根据期望的显微镜操作模式处于皮秒范围或飞秒范围; 并将过滤的斯托克斯梁，泵梁或两者提供给扫描显微镜。
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2.发明申请SYSTEM FOR NEAR-INFRARED AUTOFLUORESCENCE MEASUREMENT OF A SUBJECT, AND METHOD THEREOF 审中-公开主体近红外自动测量系统及其方法
公开(公告)号：WO2012039679A2
公开(公告)日：2012-03-29
申请号：PCT/SG2011/000322
申请日：2011-09-20
Applicant: NATIONAL UNIVERSITY OF SINGAPORE , HUANG, Zhiwei
Inventor： HUANG, Zhiwei
IPC: A61B1/07
CPC classification number: A61B1/31 , A61B1/00167 , A61B1/043
Abstract: A system for near-infrared autofluorescence measurement of a subject, the system comprising: a light source configured to emit an excitation light at near-infrared; a medium configured for delivering the excitation light to the subject; and a processing section for processing an autofluorescence signal from the subject at near-infrared resulting from the excitation light impinging upon the subject so as to analyze the subject. For example, the processing section comprises a spectrometer for detecting the autofluorescence signal at near-infrared to analyze the subject. As another example, the processing section comprises an image sensor for generating an image based on the autofluorescence signal.
Abstract translation: 一种用于对象的近红外自发荧光测量的系统，所述系统包括：被配置为发射近红外激发光的光源; 被配置为将激发光传送到被摄体的介质; 以及处理部分，用于处理来自被照射在被摄体上的激发光所产生的近红外线处的受试者的自体荧光信号，以分析被检体。 例如，处理部包括用于检测近红外线的自发荧光信号以分析被检体的光谱仪。 作为另一示例，处理部分包括用于基于自发荧光信号产生图像的图像传感器。
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公开(公告)号：WO2011162721A1
公开(公告)日：2011-12-29
申请号：PCT/SG2011/000218
申请日：2011-06-21
Applicant: NATIONAL UNIVERSITY OF SINGAPORE , HUANG, Zhiwei
Inventor： HUANG, Zhiwei
IPC: A61B1/07
CPC classification number: A61B5/0071 , A61B1/042 , A61B1/043 , A61B1/0638 , A61B5/0075 , A61B5/0084
Abstract: A method and system for performing tissue measurements. The system comprising: an endoscope for providing illumination light and for acquiring detected light from the tissue; and optical means for directing a portion of the detected light to a spectrometer and another portion of the detected light to an image capturing means.
Abstract translation: 用于进行组织测量的方法和系统。 该系统包括：用于提供照明光并用于从组织获取检测到的光的内窥镜; 以及光学装置，用于将检测到的光的一部分引导到光谱仪，并将检测到的光的另一部分引导到图像捕获装置。
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4.发明申请RAMAN SPECTROSCOPY SYSTEM, APPARATUS, AND METHOD FOR ANALYZING, CHARACTERIZING, AND/OR DIAGNOSING A TYPE OR NATURE OF A SAMPLE OR A TISSUE SUCH AS AN ABNORMAL GROWTH 审中-公开拉曼光谱系统，装置和方法用于分析，表征和/或诊断样品或组织的类型或性质，例如异常生长
公开(公告)号：WO2016003371A1
公开(公告)日：2016-01-07
申请号：PCT/SG2015/050195
申请日：2015-07-02
Applicant: NATIONAL UNIVERSITY OF SINGAPORE
Inventor： HUANG, Zhiwei
CPC classification number: G01N21/65 , A61B1/018 , A61B5/0075 , A61B5/0084 , A61B2560/0223 , G01J3/0218 , G01J3/44 , G01J2003/123 , G01N21/274 , G01N2201/0612 , G01N2201/08 , G01N2201/12 , G01N2201/129
Abstract: Characterizing, identifying, or diagnosing the type and/or nature of a sample or a tissue such as an abnormal growth using a Raman spectrum includes analyzing distinct spectral subintervals within the Raman spectrum in two distinct wavelength ranges, such as FP and HW wavelength ranges, to identify a match with one or more reference markers in one or both wavelength ranges; and from the match characterizing, identifying, or diagnosing the type and/or nature of the sample or tissue. FP and HW Raman spectra can be detected or acquired simultaneously using a single diffraction grating.
Abstract translation: 使用拉曼光谱鉴定或诊断样品或组织的异常生长的类型和/或性质包括分析两个不同波长范围（例如FP和HW波长范围）内的拉曼光谱内的不同光谱亚区域， 以在一个或两个波长范围内识别与一个或多个参考标记的匹配; 以及来自表征，识别或诊断样品或组织的类型和/或性质的匹配。 可以使用单个衍射光栅同时检测或获取FP和HW拉曼光谱。
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公开(公告)号：WO2014027967A1
公开(公告)日：2014-02-20
申请号：PCT/SG2013/000351
申请日：2013-08-16
Applicant: NATIONAL UNIVERSITY OF SINGAPORE
Inventor： HUANG, Zhiwei , BERGHOLT, Mads Sylvest , ZHENG, Wei , HO, Khek Yu
CPC classification number: A61B5/0075 , A61B5/0086 , A61B5/4233 , A61B5/4238 , A61B5/441 , A61B5/7221 , A61B5/7282 , A61B2562/0233 , G01J3/0221 , G01J3/0289 , G01J3/44 , G01N21/65
Abstract: A probe head for a diagnostic instrument using Raman spectroscopy for tissue measurements, the probe head comprising; a transmission optical fiber, a plurality of collection optical fibers, and a lens to transmit light from the transmission optical fiber to a test site, wherein the ends of the collection optical fibers are beveled or angled. The beveled surfaces can face towards or away from the end of the transmission fiber. Optical elements are used to gather and filter light scattered from tissue, and analysed to identify abnormal tissue.
Abstract translation: 用于使用拉曼光谱进行组织测量的诊断仪器的探头，所述探头包括： 传输光纤，多个收集光纤和透镜，用于将光从传输光纤传输到测试位置，其中收集光纤的端部是倾斜的或成角度的。 斜面可以面向或远离传输光纤的端部。 光学元件用于收集和过滤从组织散射的光，并分析以识别异常组织。
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Patent Agency Ranking6.发明申请A PRESSURE-SENSITIVE FIBER OPTIC PROBE FOR REAL-TIME IN VIVO TISSUE OPTICAL SPECTROSCOPY, A SYSTEM INCORPORATING THE SAME AND A METHOD FOR USING THE SAME 审中-公开一种用于体内组织光学光谱实时的压力敏感光纤探测器，包含它们的系统及其使用方法
公开(公告)号：WO2016036314A1
公开(公告)日：2016-03-10
申请号：PCT/SG2015/050289
申请日：2015-08-31
Applicant: NATIONAL UNIVERSITY OF SINGAPORE
Inventor： HUANG, Zhiwei
CPC classification number: G01N21/65 , A61B5/0075 , A61B5/6843 , A61B2562/223 , G01N21/474 , G01N21/49 , G01N21/645 , G01N2021/6417 , G01N2021/6484
Abstract: A method and system for obtaining biomedical data for diagnosis purposes, the method comprising: irradiating a tissue sample with a source of radiation;receiving a spectra collected from the tissue sample as a result of irradiation of the tissue sample from a spectrograph; delivering radiation to the sample and collecting and returning the spectra to the spectrograph via a pressure sensitive probe; measuring the pressure exerted by the probe on the tissue sample using a pressure sensor; adjusting the pressure to be at a predetermined value when the spectra is collected using a pressure adjustment module.
Abstract translation: 一种用于获得用于诊断目的的生物医学数据的方法和系统，所述方法包括：用辐射源照射组织样本;接收从组织样品收集的光谱，作为从光谱仪照射组织样品的结果; 向样品传送辐射，并通过压敏探针收集和返回光谱仪到光谱仪; 使用压力传感器测量由探针施加在组织样品上的压力; 当使用压力调节模块收集光谱时，将压力调节到预定值。
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公开(公告)号：WO2014129970A1
公开(公告)日：2014-08-28
申请号：PCT/SG2014/000063
申请日：2014-02-19
Applicant: NATIONAL UNIVERSITY OF SINGAPORE
Inventor： HUANG, Zhiwei , BERGHOLT, Mads Sylvest , ZHENG, Wei , HO, Khek Yu
CPC classification number: A61B5/0075 , A61B1/00165 , A61B5/0084 , G01J3/0218 , G01J3/0272 , G01J3/18 , G01J3/28 , G01J3/44 , G01N21/65 , G01N2201/129 , G02B23/2469 , G02B23/26
Abstract: A diagnostic instrument comprises a monochromatic light source, transmission means to transmit light from the light source to a test site, collection means to transmit scattered light from the test site, and spectral analysis apparatus to receive light from the collection means, the spectral analysis apparatus comprising a diffraction grating having a first grating element and a second grating element, wherein the first grating element diffracts light within a first wavelength range and the second grating element diffracts light within a second wavelength range, the spectral analysis apparatus further comprising a light-sensing apparatus, the first grating element arranged to diffract light onto a first area of the light-sensing apparatus and the second grating element arranged to diffract light onto a second area of the light-sensing apparatus.
Abstract translation: 诊断仪器包括单色光源，将光从光源透射到测试部位的传输装置，用于传输来自测试部位的散射光的收集装置，以及用于从收集装置接收光的光谱分析装置，光谱分析装置 包括具有第一光栅元件和第二光栅元件的衍射光栅，其中所述第一光栅元件衍射出第一波长范围内的光，并且所述第二光栅元件在第二波长范围内衍射光，所述光谱分析设备还包括光感测 装置，第一光栅元件被布置成将光衍射到光感测装置的第一区域上，第二光栅元件布置成将光衍射到光感测装置的第二区域上。
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公开(公告)号：WO2023080846A2
公开(公告)日：2023-05-11
申请号：PCT/SG2022/050804
申请日：2022-11-04
Applicant: NATIONAL UNIVERSITY OF SINGAPORE
Inventor： HUANG, Zhiwei
Abstract: The invention provides a probe (1) for measuring spectra of a target (21) within a bio-matter (2), comprising an optical structure (11) having a lens portion (111), and a communication line (12) conjoined to the optical structure (11). The optical structure (11) of the probe (1) has its exposed end tapered for forming the lens portion (111) that converges light incoming from the communication line (12) towards the target (21), and converges scattered light incoming from the target (21) towards the communication line (12). A system (3) that incorporates the probe (1), and a method of using the system (3), are further provided.
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公开(公告)号：WO2022250610A1
公开(公告)日：2022-12-01
申请号：PCT/SG2022/050340
申请日：2022-05-23
Applicant: NATIONAL UNIVERSITY OF SINGAPORE
Inventor： HUANG, Zhiwei
Abstract: A stimulated Raman scattering tomography system includes means for generating a first input light beam, means for generating a second input light beam, an objective, a condenser and a detector. The first input light beam is phase-modulated while the second input light beam is amplitude-modulated. The objective is configured to direct the first and second input light beams onto a sample. The condenser is configured to collect an output light beam from the sample. The is detector configured to detect at least a portion of the output light beam corresponding to the first input light beam. The system further includes means for forming a depth-resolved image of the sample from the detected portion of the output light beam.
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公开(公告)号：WO2018226153A1
公开(公告)日：2018-12-13
申请号：PCT/SG2018/050270
申请日：2018-06-01
Applicant: NATIONAL UNIVERSITY OF SINGAPORE
Inventor： HUANG, Zhiwei
Abstract: Disclosed is a lock-in detection free Raman imaging method of determining a stimulated Raman scattering (SRS) signal. The method comprises receiving imaging sensor data representative of a line-scan SRS signal with first and second scattering states; calculating a first scattering value based on a difference between a first intensity value of the imaging sensor data corresponding to the first scattering state and a second intensity value of the imaging sensor data corresponding to the second scattering state; and determining the line-scan SRS signal based on the calculated first scattering value.
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