公开(公告)号：WO2013139583A1

公开(公告)日：2013-09-26

申请号：PCT/EP2013/054334

申请日：2013-03-05

Applicant: NESTEC S.A.

Inventor： COLLINO, Sebastiano ,  MONTOLIU ROURA, Ivan ,  MARTIN, François-Pierre ,  GUY, Philippe, Alexandre ,  REZZI, Serge, André, Dominique

IPC: G01N33/68

CPC classification number: G01N33/493 ,  A23L33/30 ,  A23V2002/00 ,  G01N33/6893 ,  G01N33/92 ,  G01N2800/50 ,  G01N2800/7042 ,  G01N2800/7095 ,  G01R33/44 ,  H01J49/0027 ,  Y10T436/173845 ,  Y10T436/18 ,  Y10T436/203332 ,  Y10T436/24

Abstract: Using NMR/MS based metabonomics and targeted lipidomics approaches the inventors haveexploredthe metabolic phenotypes of aging and longevity in a cohort compromising centenarians, elderly and young adults. The inventors have identified biomarkers for a reduced risk of developing ageing related chronic inflammatory disorders and propose an in vitro method of diagnosing a lifestyle that allows to delay and/or avoid ageing related chronic inflammatory disorders using p-cresol sulphate as biomarker.

Abstract translation: 使用基于NMR / MS的代谢组学和靶向脂质组学方法，发明人已经研究了老年人和年轻成年人的老龄化和长寿的代谢表型。 本发明人已经鉴定出降低发展与衰老相关的慢性炎症性疾病的风险的生物标志物，并提出了一种诊断生活方式的体外方法，该方法允许使用对甲酚硫酸盐作为生物标志物来延缓和/或避免与衰老有关的慢性炎症性疾病。

公开(公告)号：WO2013139580A1

公开(公告)日：2013-09-26

申请号：PCT/EP2013/054327

申请日：2013-03-05

Applicant: NESTEC S.A.

Inventor： COLLINO, Sebastiano ,  MONTOLIU ROURA, Ivan ,  MARTIN, François-Pierre ,  GUY, Philippe Alexandre ,  REZZI, Serge André Dominique

IPC: G01N33/68

CPC classification number: G01N33/54306 ,  G01N33/6842 ,  G01N33/6848 ,  G01N33/6893 ,  G01N2800/50 ,  G01N2800/60 ,  G01N2800/7042 ,  G01N2800/7095 ,  Y10T436/173845 ,  Y10T436/182 ,  Y10T436/200833 ,  Y10T436/203332 ,  Y10T436/24

Abstract: Using NMR/MS based metabonomics and targeted lipidomics approaches the inventors have explored the metabolic phenotypes of aging and longevity in a cohort compromising centenarians, elderly and young adults. The inventors have identified biomarkers for a reduced risk of developing ageing related chronic inflammatory disorders and propose an in vitro method of diagnosing a lifestyle that allows delaying and/or avoiding ageing related chronic inflammatory disorders using phenylacetylglutamine (PAG) as biomarker.

Abstract translation: 使用基于NMR / MS的代谢组学和靶向脂质组学方法，发明人已经探索了老年人和年轻成年人的老龄化和长寿的代谢表型。 本发明人已经鉴定了降低发展与衰老有关的慢性炎症性疾病的风险的生物标志物，并提出了使用苯乙酰谷氨酰胺（PAG）作为生物标志物来延缓和/或避免老化相关的慢性炎性疾病的生活方式的体外诊断方法。

公开(公告)号：WO2014086604A1

公开(公告)日：2014-06-12

申请号：PCT/EP2013/074567

申请日：2013-11-25

Applicant: NESTEC S.A.

Inventor： MARTIN, François-Pierre ,  BOULANGE, Claire L. ,  MONTOLIU ROURA, Ivan ,  COLLINO, Sebastiano ,  DUMAS, Marc-Emmanuel ,  HOLMES, Elaine ,  REZZI, Serge André Dominique ,  NICHOLSON, Jeremy ,  KOCHHAR, Sunil

IPC: G01N33/50

CPC classification number: G01N33/50 ,  A61B5/4872 ,  G01N2800/044 ,  G01N2800/50

Abstract: The present invention relates generally to the field of nutrition and health. In particular, the present invention relates to a new biomarker, its use and a nnethod that allows it to diagnose the likelihood to resist diet induced weight gain, and/or to be susceptible to a diet induced weight gain. For example, the biomarker may be trimethylamine-N-oxide.

Abstract translation: 本发明一般涉及营养和健康领域。 特别地，本发明涉及一种新的生物标志物，其用途和方法，其允许其诊断抵抗饮食诱导的体重增加的可能性，和/或易于饮食诱导的体重增加。 例如，生物标志物可以是三甲胺-N-氧化物。

公开(公告)号：WO2013139582A1

公开(公告)日：2013-09-26

申请号：PCT/EP2013/054332

申请日：2013-03-05

Applicant: NESTEC S.A.

Inventor： COLLINO, Sebastiano ,  MONTOLIU ROURA, Ivan ,  MARTIN, François-Pierre ,  GUY, Philippe Alexandre ,  REZZI, Serge André Dominique

IPC: G01N33/68 ,  G01N33/92

CPC classification number: G01N33/49 ,  G01N33/492 ,  G01N33/493 ,  G01N33/6848 ,  G01N33/6893 ,  G01N33/92 ,  G01N2405/06 ,  G01N2570/00 ,  G01N2800/04 ,  G01N2800/50 ,  G01N2800/7042 ,  G01N2800/7095 ,  G09B19/00 ,  G09B19/0092

Abstract: Using NMR/MS based metabonomics and targeted lipidomics approaches the inventors have explored the metabolic phenotypes of aging and longevity in a cohort compromising centenarians, elderly and young adults. The inventors have identified biomarkers for a reduced risk of developing ageing related chronic inflammatory disorders and propose a method of diagnosing a lifestyle that allows delaying and/or avoiding ageing related chronic inflammatory disorders using PC-O 40:1 as biomarker.

Abstract translation: 使用基于NMR / MS的代谢组学和靶向脂质组学方法，发明人已经探索了老年人和年轻成年人的老龄化和长寿的代谢表型。 本发明人已经鉴定出降低发展与衰老有关的慢性炎症性疾病的风险的生物标志物，并且提出了一种诊断生活方式的方法，该方法允许使用PC-O 40：1作为生物标志物延迟和/或避免与衰老有关的慢性炎症性疾病。

公开(公告)号：WO2014154494A1

公开(公告)日：2014-10-02

申请号：PCT/EP2014/054913

申请日：2014-03-13

Applicant: NESTEC S.A.

Inventor： MARTIN, François-Pierre ,  COLLINO, Sebastiano ,  MONTOLIU ROURA, Ivan

IPC: G01N33/48 ,  G01N33/493

CPC classification number: G01N33/493 ,  A61K31/715 ,  A61K31/733 ,  C12Q2565/633 ,  G01N24/08 ,  G01N33/50 ,  G01N33/6893 ,  G01N2570/00 ,  G01N2800/044 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/70

Abstract: The present invention relates generally to the field of nutrition and health, particular, the present invention relates to alpha-keto-isovalerate as a biomarker urine of the efficacy of prebiotics for the prevention of diet induced weight gain.

Abstract translation: 本发明一般涉及营养和健康领域，特别地，本发明涉及α-酮 - 异戊酸酯作为益生元用于预防饮食诱导体重增加的功效的生物标志物尿。

公开(公告)号：WO2014154493A1

公开(公告)日：2014-10-02

申请号：PCT/EP2014/054912

申请日：2014-03-13

Applicant: NESTEC S.A.

Inventor： MARTIN, François-Pierre ,  COLLINO, Sebastiano ,  MONTOLIU ROURA, Ivan

IPC: G01N33/493 ,  G01N33/48

CPC classification number: G01N33/493 ,  A61K31/702 ,  C12Q2565/633 ,  G01N24/08 ,  G01N33/50 ,  G01N33/62 ,  G01N33/6893 ,  G01N2570/00 ,  G01N2800/02 ,  G01N2800/044 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/60 ,  G01N2800/70

Abstract: The present invention relates generally to the field of nutrition and health. In particular, the present invention relates to indoxyl sulfate as a biomarker in urine of the efficacy of prebiotics for the prevention of diet induced weight gain.

Abstract translation: 本发明一般涉及营养和健康领域。 特别地，本发明涉及作为益生元的功效的尿中生物标志物的吲哚硫酸盐作为预防饮食诱导的体重增加。

公开(公告)号：WO2014086603A1

公开(公告)日：2014-06-12

申请号：PCT/EP2013/074566

申请日：2013-11-25

Applicant: NESTEC S.A.

Inventor： MARTIN, François-Pierre ,  BOULANGE, Claire L. ,  MONTOLIU ROURA, Ivan ,  COLLINO, Sebastiano ,  DUMAS, Marc-Emmanuel ,  HOLMES, Elaine ,  REZZI, Serge André Dominique ,  NICHOLSON, Jeremy ,  KOCHHAR, Sunil

IPC: G01N33/68

CPC classification number: G01N33/6812 ,  G01N24/08 ,  G01N33/6893 ,  G01N2800/044 ,  H01J49/0027

Abstract: The present invention relates generally to the field of nutrition and health. In particular, the present invention relates to a new biomarker, its use and a method that allows it to diagnose the likelihood to resist diet induced weight gain, and/or to be susceptible to a diet induced weight gain. For example, the biomarker may be hexanoylglycine.

Abstract translation: 本发明一般涉及营养和健康领域。 特别地，本发明涉及新的生物标志物，其用途和方法，其允许其诊断抵抗饮食诱导的体重增加的可能性，和/或易于饮食诱导的体重增加。 例如，生物标记可以是己酰甘氨酸。

公开(公告)号：WO2014154492A1

公开(公告)日：2014-10-02

申请号：PCT/EP2014/054909

申请日：2014-03-13

Applicant: NESTEC S.A.

Inventor： MARTIN, François-Pierre ,  COLLINO, Sebastiano ,  MONTOLIU ROURA, Ivan

IPC: G01N33/68

CPC classification number: G01N33/493 ,  A61K31/702 ,  A61K31/733 ,  G01N33/6893 ,  G01N2800/044 ,  G01N2800/52

Abstract: The present invention relates generally to the field of nutrition and health. In particular, the present invention relates to trimethylamine as a biomarker in urine of the efficacy of prebiotics for the prevention of diet induced weight gain.

Abstract translation: 本发明一般涉及营养和健康领域。 特别地，本发明涉及三氨基胺作为尿中生物标志物的益生元的功效，用于预防饮食诱导的体重增加。

公开(公告)号：WO2014086605A1

公开(公告)日：2014-06-12

申请号：PCT/EP2013/074570

申请日：2013-11-25

Applicant: NESTEC S.A.

Inventor： MARTIN, François-Pierre ,  BOULANGE, Claire L. ,  MONTOLIU ROURA, Ivan ,  COLLINO, Sebastiano ,  DUMAS, Marc-Emmanuel ,  HOLMES, Elaine ,  REZZI, Serge André Dominique ,  NICHOLSON, Jeremy ,  KOCHHAR, Sunil

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  C12Q1/61 ,  C12Q2565/633 ,  G01N24/08 ,  G01N33/50 ,  G01N33/6806 ,  G01N2800/044 ,  G01N2800/50 ,  G01N2800/60 ,  G01N2800/70

Abstract: The present invention relates generally to the field of nutrition and health. In particular, the present invention relates to a new biomarker, its use and a method that allows it to diagnose the likelihood to resist diet induced weight gain, and/or to be susceptible to a diet induced weight gain. For example, the biomarker may be isovalerylglycine.

Abstract translation: 本发明一般涉及营养和健康领域。 特别地，本发明涉及新的生物标志物，其用途和方法，其允许其诊断抵抗饮食诱导的体重增加的可能性，和/或易于饮食诱导的体重增加。 例如，生物标志物可以是异戊酰甘氨酸。

公开(公告)号：WO2013139584A1

公开(公告)日：2013-09-26

申请号：PCT/EP2013/054335

申请日：2013-03-05

Applicant: NESTEC S.A.

Inventor： COLLINO, Sebastiano ,  MONTOLIU ROURA, Ivan ,  MARTIN, François-Pierre ,  GUY, Philippe Alexandre ,  REZZI, Serge André Dominique

IPC: G01N33/68 ,  G01N33/92

CPC classification number: G01N33/92 ,  G01N33/50 ,  G01N33/6812 ,  G01N33/6893 ,  G01N2405/08 ,  G01N2800/7042

Abstract: Using NMR/MS based metabonomics and targeted lipidomics approaches the inventors have explored the metabolic phenotypes of aging and longevity in a cohort compromising centenarians, elderly and young adults. The inventors have identified biomarkers for a reduced risk of developing ageing related chronic inflammatory disorders and propose a method of diagnosing a lifestyle that allows delaying and/or avoiding ageing related chronic inflammatory disorders using hydroxy- sphingomyelin SM-OH-22:1as biomarker.

Abstract translation: 使用基于NMR / MS的代谢组学和靶向脂质组学方法，发明人已经探索了老年人和年轻成年人的老龄化和长寿的代谢表型。 本发明人已经鉴定出降低发展与衰老有关的慢性炎症性疾病风险的生物标志物，并提出了一种诊断生活方式的方法，该方法允许使用羟基鞘磷脂SM-OH-22：1作为生物标志物来延缓和/或避免老化相关的慢性炎症性疾病。