公开(公告)号：WO2013181375A1

公开(公告)日：2013-12-05

申请号：PCT/US2013/043336

申请日：2013-05-30

Applicant: NEW YORK UNIVERSITY

Inventor： RICCI, John, L. ,  CLARK, Elizabeth ,  COELHO, Paulo ,  VAN THOMPSON, Dianne, Rekow ,  SMAY, James

IPC: A61L27/56 ,  A61F2/02 ,  A61F2/28 ,  A61L27/54

CPC classification number: A61F2/28 ,  A61F2/2875 ,  A61F2/3094 ,  A61F2002/2817 ,  A61F2002/30011 ,  A61F2002/30235 ,  A61F2002/30574 ,  A61F2002/3092 ,  A61F2002/30962 ,  A61F2002/30968 ,  A61F2002/30985 ,  A61F2310/00179 ,  A61L27/025 ,  A61L27/54 ,  A61L27/56 ,  A61L2430/02 ,  B33Y80/00

Abstract: The present invention relates to multiphasic, three-dimensionally printed, tissue repair devices or scaffolds useful for promoting bone growth and treating bone fracture, defect or deficiency, methods for making the same and methods for promoting bone growth and treating bone fracture, defect or deficiency using the same. The scaffold has a porous bone ingrowth area containing interconnected struts surrounded by a microporous shell. At the ends of the scaffold, the shell may be extended as a guide flange to stabilize the scaffold between ends of bone. The center of the scaffold may be empty and may serve as a potential marrow space. The porous ingrowth structure may be infiltrated with a soluble filler or carrier, such as, for example calcium sulfate which may be infiltrated with one or more of an antibiotic, a growth factor, a differentiation factors, a cytokine, a drug, or a combination of these agents.

Abstract translation: 本发明涉及可用于促进骨生长和治疗骨折，缺陷或不足的多相，三维印刷的组织修复装置或支架，其制备方法以及用于促进骨生长和治疗骨折，缺陷或缺陷的方法 使用相同 支架具有包含由微孔壳包围的相互连接的支柱的多孔骨向内生长区域。 在支架的端部，壳可以作为引导凸缘延伸，以在骨的端部之间稳定支架。 脚手架的中心可能是空的，可以作为潜在的骨髓空间。 多孔向内生长结构可以用可溶性填料或载体渗透，例如硫酸钙，其可以用抗生素，生长因子，分化因子，细胞因子，药物或组合中的一种或多种渗透 的这些药剂。